8IAQ

Respiratory complex Membrane domain of CI, focused map of type I, Wild type mouse under thermoneutral temperature

Functional Information from GO Data

Chain	GOid	namespace	contents
c	0003674	molecular_function	molecular_function
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0009060	biological_process	aerobic respiration
c	0022904	biological_process	respiratory electron transport chain
c	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
c	0045271	cellular_component	respiratory chain complex I
d	0005737	cellular_component	cytoplasm
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0009060	biological_process	aerobic respiration
d	0010918	biological_process	positive regulation of mitochondrial membrane potential
d	0022904	biological_process	respiratory electron transport chain
d	0032981	biological_process	mitochondrial respiratory chain complex I assembly
d	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
d	0045271	cellular_component	respiratory chain complex I
d	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
d	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
d	2001171	biological_process	positive regulation of ATP biosynthetic process
D	0003954	molecular_function	NADH dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0009060	biological_process	aerobic respiration
D	0016491	molecular_function	oxidoreductase activity
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0019826	molecular_function	oxygen sensor activity
D	0022008	biological_process	neurogenesis
D	0022904	biological_process	respiratory electron transport chain
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D	0042063	biological_process	gliogenesis
D	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045271	cellular_component	respiratory chain complex I
D	0046872	molecular_function	metal ion binding
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0061351	biological_process	neural precursor cell proliferation
D	0071453	biological_process	cellular response to oxygen levels
D	1902600	biological_process	proton transmembrane transport
e	0003674	molecular_function	molecular_function
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0005758	cellular_component	mitochondrial intermembrane space
e	0009060	biological_process	aerobic respiration
e	0022904	biological_process	respiratory electron transport chain
e	0032981	biological_process	mitochondrial respiratory chain complex I assembly
e	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
e	0045271	cellular_component	respiratory chain complex I
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0009060	biological_process	aerobic respiration
f	0016607	cellular_component	nuclear speck
f	0022904	biological_process	respiratory electron transport chain
f	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
f	0045271	cellular_component	respiratory chain complex I
g	0001669	cellular_component	acrosomal vesicle
g	0003674	molecular_function	molecular_function
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0009060	biological_process	aerobic respiration
g	0022904	biological_process	respiratory electron transport chain
g	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
g	0045271	cellular_component	respiratory chain complex I
g	0097225	cellular_component	sperm midpiece
g	0097228	cellular_component	sperm principal piece
g	0097229	cellular_component	sperm end piece
g	0120212	cellular_component	sperm head-tail coupling apparatus
h	0003674	molecular_function	molecular_function
h	0005654	cellular_component	nucleoplasm
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0009060	biological_process	aerobic respiration
h	0022904	biological_process	respiratory electron transport chain
h	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
h	0045271	cellular_component	respiratory chain complex I
i	0005654	cellular_component	nucleoplasm
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0009060	biological_process	aerobic respiration
i	0022904	biological_process	respiratory electron transport chain
i	0031966	cellular_component	mitochondrial membrane
i	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
i	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
i	0045271	cellular_component	respiratory chain complex I
j	0003674	molecular_function	molecular_function
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0009060	biological_process	aerobic respiration
j	0022904	biological_process	respiratory electron transport chain
j	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
j	0045271	cellular_component	respiratory chain complex I
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0009060	biological_process	aerobic respiration
J	0022904	biological_process	respiratory electron transport chain
J	0032981	biological_process	mitochondrial respiratory chain complex I assembly
J	0035094	biological_process	response to nicotine
J	0042220	biological_process	response to cocaine
J	0042542	biological_process	response to hydrogen peroxide
J	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
J	0045271	cellular_component	respiratory chain complex I
J	1902600	biological_process	proton transmembrane transport
k	0003674	molecular_function	molecular_function
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0009060	biological_process	aerobic respiration
k	0022900	biological_process	electron transport chain
k	0022904	biological_process	respiratory electron transport chain
k	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
k	0045271	cellular_component	respiratory chain complex I
K	0005743	cellular_component	mitochondrial inner membrane
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0009060	biological_process	aerobic respiration
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0022904	biological_process	respiratory electron transport chain
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
K	0045271	cellular_component	respiratory chain complex I
K	1902600	biological_process	proton transmembrane transport
l	0003674	molecular_function	molecular_function
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0009060	biological_process	aerobic respiration
l	0022904	biological_process	respiratory electron transport chain
l	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
l	0045271	cellular_component	respiratory chain complex I
L	0005743	cellular_component	mitochondrial inner membrane
L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0009060	biological_process	aerobic respiration
L	0015990	biological_process	electron transport coupled proton transport
L	0022904	biological_process	respiratory electron transport chain
L	0032981	biological_process	mitochondrial respiratory chain complex I assembly
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
L	0045271	cellular_component	respiratory chain complex I
m	0003674	molecular_function	molecular_function
m	0005654	cellular_component	nucleoplasm
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0009060	biological_process	aerobic respiration
m	0022904	biological_process	respiratory electron transport chain
m	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
m	0045271	cellular_component	respiratory chain complex I
M	0001666	biological_process	response to hypoxia
M	0001701	biological_process	in utero embryonic development
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005743	cellular_component	mitochondrial inner membrane
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0021549	biological_process	cerebellum development
M	0022904	biological_process	respiratory electron transport chain
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0035094	biological_process	response to nicotine
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
M	0045271	cellular_component	respiratory chain complex I
M	0045471	biological_process	response to ethanol
M	0048039	molecular_function	ubiquinone binding
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0009060	biological_process	aerobic respiration
n	0022904	biological_process	respiratory electron transport chain
n	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
n	0045271	cellular_component	respiratory chain complex I
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009060	biological_process	aerobic respiration
N	0019901	molecular_function	protein kinase binding
N	0022904	biological_process	respiratory electron transport chain
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0035255	molecular_function	ionotropic glutamate receptor binding
N	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
N	0045271	cellular_component	respiratory chain complex I
N	0072593	biological_process	reactive oxygen species metabolic process
N	1902600	biological_process	proton transmembrane transport
o	0003674	molecular_function	molecular_function
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005758	cellular_component	mitochondrial intermembrane space
o	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
o	0009060	biological_process	aerobic respiration
o	0022904	biological_process	respiratory electron transport chain
o	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
o	0045271	cellular_component	respiratory chain complex I
o	1902600	biological_process	proton transmembrane transport
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005759	cellular_component	mitochondrial matrix
O	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
O	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
O	0009060	biological_process	aerobic respiration
O	0022904	biological_process	respiratory electron transport chain
O	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
O	0043209	cellular_component	myelin sheath
O	0045271	cellular_component	respiratory chain complex I
O	1902600	biological_process	proton transmembrane transport
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0009060	biological_process	aerobic respiration
p	0022904	biological_process	respiratory electron transport chain
p	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
p	0045271	cellular_component	respiratory chain complex I
U	0000035	molecular_function	acyl binding
U	0000036	molecular_function	acyl carrier activity
U	0005198	molecular_function	structural molecule activity
U	0005654	cellular_component	nucleoplasm
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006629	biological_process	lipid metabolic process
U	0006631	biological_process	fatty acid metabolic process
U	0006633	biological_process	fatty acid biosynthetic process
U	0009060	biological_process	aerobic respiration
U	0009249	biological_process	protein lipoylation
U	0016226	biological_process	iron-sulfur cluster assembly
U	0022904	biological_process	respiratory electron transport chain
U	0031966	cellular_component	mitochondrial membrane
U	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
U	0044571	biological_process	[2Fe-2S] cluster assembly
U	0045271	cellular_component	respiratory chain complex I
U	0099128	cellular_component	mitochondrial [2Fe-2S] assembly complex
U	0140978	molecular_function	mitochondrial large ribosomal subunit binding
U	1902775	biological_process	mitochondrial large ribosomal subunit assembly
X	0005739	cellular_component	mitochondrion
X	0005743	cellular_component	mitochondrial inner membrane
X	0005758	cellular_component	mitochondrial intermembrane space
X	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
X	0009060	biological_process	aerobic respiration
X	0022904	biological_process	respiratory electron transport chain
X	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
X	0044877	molecular_function	protein-containing complex binding
X	0045271	cellular_component	respiratory chain complex I
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Y	0045271	cellular_component	respiratory chain complex I

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
U	ASP107-MET122

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
U	ASP132-ILE144

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
D	LEU116-LYS127

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1098
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"PubMed","id":"24652937","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	75
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	86
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"UniProtKB","id":"Q02367","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q9Y6M9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9Y6M9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Lipidation: {"description":"N-myristoyl glycine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	10
Details	Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O96000","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---