8IAM

Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3D) complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009058	biological_process	biosynthetic process
A	0030170	molecular_function	pyridoxal phosphate binding
B	0004758	molecular_function	serine C-palmitoyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0006629	biological_process	lipid metabolic process
B	0006665	biological_process	sphingolipid metabolic process
B	0009058	biological_process	biosynthetic process
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0017059	cellular_component	serine palmitoyltransferase complex
B	0030148	biological_process	sphingolipid biosynthetic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0046512	biological_process	sphingosine biosynthetic process
B	0046513	biological_process	ceramide biosynthetic process
B	0090156	biological_process	intracellular sphingolipid homeostasis
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006629	biological_process	lipid metabolic process
C	0006665	biological_process	sphingolipid metabolic process
C	0006666	biological_process	3-keto-sphinganine metabolic process
C	0008047	molecular_function	enzyme activator activity
C	0016020	cellular_component	membrane
C	0017059	cellular_component	serine palmitoyltransferase complex
C	0090154	biological_process	positive regulation of sphingolipid biosynthetic process
C	0090156	biological_process	intracellular sphingolipid homeostasis
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006629	biological_process	lipid metabolic process
D	0006665	biological_process	sphingolipid metabolic process
D	0006672	biological_process	ceramide metabolic process
D	0006897	biological_process	endocytosis
D	0006986	biological_process	response to unfolded protein
D	0016020	cellular_component	membrane
D	0017059	cellular_component	serine palmitoyltransferase complex
D	0030148	biological_process	sphingolipid biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0090155	biological_process	negative regulation of sphingolipid biosynthetic process
D	0090156	biological_process	intracellular sphingolipid homeostasis
E	0009058	biological_process	biosynthetic process
E	0030170	molecular_function	pyridoxal phosphate binding
F	0004758	molecular_function	serine C-palmitoyltransferase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0006629	biological_process	lipid metabolic process
F	0006665	biological_process	sphingolipid metabolic process
F	0009058	biological_process	biosynthetic process
F	0016020	cellular_component	membrane
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0017059	cellular_component	serine palmitoyltransferase complex
F	0030148	biological_process	sphingolipid biosynthetic process
F	0030170	molecular_function	pyridoxal phosphate binding
F	0046512	biological_process	sphingosine biosynthetic process
F	0046513	biological_process	ceramide biosynthetic process
F	0090156	biological_process	intracellular sphingolipid homeostasis
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006629	biological_process	lipid metabolic process
G	0006665	biological_process	sphingolipid metabolic process
G	0006666	biological_process	3-keto-sphinganine metabolic process
G	0008047	molecular_function	enzyme activator activity
G	0016020	cellular_component	membrane
G	0017059	cellular_component	serine palmitoyltransferase complex
G	0090154	biological_process	positive regulation of sphingolipid biosynthetic process
G	0090156	biological_process	intracellular sphingolipid homeostasis
H	0003674	molecular_function	molecular_function
H	0005515	molecular_function	protein binding
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0006629	biological_process	lipid metabolic process
H	0006665	biological_process	sphingolipid metabolic process
H	0006672	biological_process	ceramide metabolic process
H	0006897	biological_process	endocytosis
H	0006986	biological_process	response to unfolded protein
H	0016020	cellular_component	membrane
H	0017059	cellular_component	serine palmitoyltransferase complex
H	0030148	biological_process	sphingolipid biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0090155	biological_process	negative regulation of sphingolipid biosynthetic process
H	0090156	biological_process	intracellular sphingolipid homeostasis

Functional Information from PROSITE/UniProt

site_id	PS00599
Number of Residues	10
Details	AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TFTKSFGAAG

Chain	Residue	Details
B	THR363-GLY372

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	512
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15485854","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	122
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	104
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"15485854","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	280
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	46
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---