Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8I9A

Structure of EP54-C3aR-Gq complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0019001	molecular_function	guanyl nucleotide binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
B	0001750	cellular_component	photoreceptor outer segment
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B	0007265	biological_process	Ras protein signal transduction
B	0008283	biological_process	cell population proliferation
B	0016020	cellular_component	membrane
B	0030159	molecular_function	signaling receptor complex adaptor activity
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0050909	biological_process	sensory perception of taste
B	0051020	molecular_function	GTPase binding
B	0060041	biological_process	retina development in camera-type eye
B	0070062	cellular_component	extracellular exosome
B	0071380	biological_process	cellular response to prostaglandin E stimulus
B	0071870	biological_process	cellular response to catecholamine stimulus
B	0097381	cellular_component	photoreceptor disc membrane
B	1903561	cellular_component	extracellular vesicle
C	0002430	biological_process	complement receptor mediated signaling pathway
C	0002682	biological_process	regulation of immune system process
C	0004875	molecular_function	complement receptor activity
C	0004876	molecular_function	complement component C3a receptor activity
C	0004878	molecular_function	complement component C5a receptor activity
C	0004930	molecular_function	G protein-coupled receptor activity
C	0005886	cellular_component	plasma membrane
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0008015	biological_process	blood circulation
C	0010575	biological_process	positive regulation of vascular endothelial growth factor production
C	0010759	biological_process	positive regulation of macrophage chemotaxis
C	0016020	cellular_component	membrane
C	0019722	biological_process	calcium-mediated signaling
C	0035577	cellular_component	azurophil granule membrane
C	0035579	cellular_component	specific granule membrane
C	0038178	biological_process	complement component C5a signaling pathway
C	0045766	biological_process	positive regulation of angiogenesis
C	0090023	biological_process	positive regulation of neutrophil chemotaxis
G	0005515	molecular_function	protein binding
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G	0016020	cellular_component	membrane
G	0031681	molecular_function	G-protein beta-subunit binding
G	0045202	cellular_component	synapse
G	0048144	biological_process	fibroblast proliferation
G	0070062	cellular_component	extracellular exosome
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	0071870	biological_process	cellular response to catecholamine stimulus

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfLLTAISLDRCLvV

Chain	Residue	Details
C	ALA108-VAL124

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744\|PDB:1KJY, ECO:0007744\|PDB:2OM2, ECO:0007744\|PDB:2XNS, ECO:0007744\|PDB:3ONW, ECO:0007744\|PDB:3QE0, ECO:0007744\|PDB:3QI2, ECO:0007744\|PDB:4G5Q

Chain	Residue	Details
A	SER174

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744\|PDB:1KJY, ECO:0007744\|PDB:1Y3A, ECO:0007744\|PDB:2G83, ECO:0007744\|PDB:2GTP, ECO:0007744\|PDB:2IK8, ECO:0007744\|PDB:2OM2, ECO:0007744\|PDB:2XNS, ECO:0007744\|PDB:3ONW, ECO:0007744\|PDB:3QE0, ECO:0007744\|PDB:3QI2, ECO:0007744\|PDB:3UMR, ECO:0007744\|PDB:3UMS, ECO:0007744\|PDB:4G5Q

Chain	Residue	Details
A	LEU198
C	ASP119-ALA139
C	PHE361-ARG377
C	GLY439-VAL482

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:18434541, ECO:0000269\|PubMed:22383884, ECO:0007744\|PDB:3QE0

Chain	Residue	Details
A	THR204

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250

Chain	Residue	Details
A	ARG201
C	ARG161-ARG340
C	LEU401-ASP417

site_id	SWS_FT_FI5
Number of Residues	1
Details	LIPID: N-myristoyl glycine => ECO:0000269\|PubMed:20213681, ECO:0000269\|PubMed:25255805

Chain	Residue	Details
A	GLY9

site_id	SWS_FT_FI6
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000250\|UniProtKB:P10824

Chain	Residue	Details
A	CYS10

site_id	SWS_FT_FI7
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P04896

Chain	Residue	Details
A	GLY47
A	SER54
A	ASP223
A	ASN292
A	SER366

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	SER352

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
A	LYS300

site_id	SWS_FT_FI10
Number of Residues	3
Details	MOD_RES: Sulfotyrosine => ECO:0000269\|PubMed:12871936

Chain	Residue	Details
C	TYR174
C	TYR184
C	TYR318

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:O09047

Chain	Residue	Details
C	SER459

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:O09047

Chain	Residue	Details
C	THR463

site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN9
C	ASN194

site_id	SWS_FT_FI14
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269\|PubMed:23234360

Chain	Residue	Details
C	SER266

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)