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8I93

ACE2-B0AT1 complex bound with methionine

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0001817biological_processregulation of cytokine production
A0002003biological_processangiotensin maturation
A0003051biological_processangiotensin-mediated drinking behavior
A0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
A0004175molecular_functionendopeptidase activity
A0004180molecular_functioncarboxypeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008241molecular_functionpeptidyl-dipeptidase activity
A0008270molecular_functionzinc ion binding
A0009986cellular_componentcell surface
A0015827biological_processtryptophan transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0019058biological_processviral life cycle
A0019065biological_processreceptor-mediated endocytosis of virus by host cell
A0019229biological_processregulation of vasoconstriction
A0022898biological_processregulation of transmembrane transporter activity
A0030666cellular_componentendocytic vesicle membrane
A0031526cellular_componentbrush border membrane
A0042127biological_processregulation of cell population proliferation
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0045121cellular_componentmembrane raft
A0046718biological_processsymbiont entry into host cell
A0046813biological_processreceptor-mediated virion attachment to host cell
A0046872molecular_functionmetal ion binding
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050727biological_processregulation of inflammatory response
A0051957biological_processpositive regulation of amino acid transport
A0060135biological_processmaternal process involved in female pregnancy
A0060452biological_processpositive regulation of cardiac muscle contraction
A0061025biological_processmembrane fusion
A0070062cellular_componentextracellular exosome
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0097746biological_processblood vessel diameter maintenance
A0098670biological_processentry receptor-mediated virion attachment to host cell
A1903598biological_processpositive regulation of gap junction assembly
A1903779biological_processregulation of cardiac conduction
A1905737biological_processpositive regulation of L-proline import across plasma membrane
A2000272biological_processnegative regulation of signaling receptor activity
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0003333biological_processamino acid transmembrane transport
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006865biological_processamino acid transport
B0007584biological_processresponse to nutrient
B0015171molecular_functionamino acid transmembrane transporter activity
B0015175molecular_functionneutral L-amino acid transmembrane transporter activity
B0015293molecular_functionsymporter activity
B0015804biological_processneutral amino acid transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0019058biological_processviral life cycle
B0022857molecular_functiontransmembrane transporter activity
B0031526cellular_componentbrush border membrane
B0035725biological_processsodium ion transmembrane transport
B0070062cellular_componentextracellular exosome
C0001618molecular_functionvirus receptor activity
C0001817biological_processregulation of cytokine production
C0002003biological_processangiotensin maturation
C0003051biological_processangiotensin-mediated drinking behavior
C0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
C0004175molecular_functionendopeptidase activity
C0004180molecular_functioncarboxypeptidase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005788cellular_componentendoplasmic reticulum lumen
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006508biological_processproteolysis
C0008237molecular_functionmetallopeptidase activity
C0008241molecular_functionpeptidyl-dipeptidase activity
C0008270molecular_functionzinc ion binding
C0009986cellular_componentcell surface
C0015827biological_processtryptophan transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0019058biological_processviral life cycle
C0019065biological_processreceptor-mediated endocytosis of virus by host cell
C0019229biological_processregulation of vasoconstriction
C0022898biological_processregulation of transmembrane transporter activity
C0030666cellular_componentendocytic vesicle membrane
C0031526cellular_componentbrush border membrane
C0042127biological_processregulation of cell population proliferation
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0045121cellular_componentmembrane raft
C0046718biological_processsymbiont entry into host cell
C0046813biological_processreceptor-mediated virion attachment to host cell
C0046872molecular_functionmetal ion binding
C0048662biological_processnegative regulation of smooth muscle cell proliferation
C0050727biological_processregulation of inflammatory response
C0051957biological_processpositive regulation of amino acid transport
C0060135biological_processmaternal process involved in female pregnancy
C0060452biological_processpositive regulation of cardiac muscle contraction
C0061025biological_processmembrane fusion
C0070062cellular_componentextracellular exosome
C0070373biological_processnegative regulation of ERK1 and ERK2 cascade
C0097746biological_processblood vessel diameter maintenance
C0098670biological_processentry receptor-mediated virion attachment to host cell
C1903598biological_processpositive regulation of gap junction assembly
C1903779biological_processregulation of cardiac conduction
C1905737biological_processpositive regulation of L-proline import across plasma membrane
C2000272biological_processnegative regulation of signaling receptor activity
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
D0003333biological_processamino acid transmembrane transport
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006865biological_processamino acid transport
D0007584biological_processresponse to nutrient
D0015171molecular_functionamino acid transmembrane transporter activity
D0015175molecular_functionneutral L-amino acid transmembrane transporter activity
D0015293molecular_functionsymporter activity
D0015804biological_processneutral amino acid transport
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0019058biological_processviral life cycle
D0022857molecular_functiontransmembrane transporter activity
D0031526cellular_componentbrush border membrane
D0035725biological_processsodium ion transmembrane transport
D0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ
ChainResidueDetails
ATHR371-GLN380

site_idPS00610
Number of Residues15
DetailsNA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcqsHGGGaF
ChainResidueDetails
BTRP56-PHE70

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
BMET42-CYS62
DMET42-CYS62

site_idSWS_FT_FI2
Number of Residues412
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLN63-GLY67
DGLY326-SER413
DGLY478-GLY490
DGLU553-TRP581
BASN142-SER192
BTHR243-TRP268
BGLY326-SER413
BGLY478-GLY490
BGLU553-TRP581
DGLN63-GLY67
DASN142-SER192
DTHR243-TRP268

site_idSWS_FT_FI3
Number of Residues40
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
BGLY68-LEU88
DGLY68-LEU88

site_idSWS_FT_FI4
Number of Residues184
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BGLU89-LEU120
DASP512-GLN531
BARG214-LYS221
BSER290-VAL304
BASN435-GLU456
BASP512-GLN531
DGLU89-LEU120
DARG214-LYS221
DSER290-VAL304
DASN435-GLU456

site_idSWS_FT_FI5
Number of Residues40
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
BTHR121-PHE141
DTHR121-PHE141
ATYR515
CARG273
CHIS345
CTYR515

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
BILE193-ILE213
DILE193-ILE213
AGLU402
CHIS374
CHIS378
CGLU402

site_idSWS_FT_FI7
Number of Residues40
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
BALA222-LEU242
DALA222-LEU242
CASN53
CASN322

site_idSWS_FT_FI8
Number of Residues40
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
BLEU269-PHE289
DLEU269-PHE289

site_idSWS_FT_FI9
Number of Residues40
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
BILE305-ILE325
DILE305-ILE325
CASN103
CASN432

site_idSWS_FT_FI10
Number of Residues40
DetailsTRANSMEM: Helical; Name=8 => ECO:0000255
ChainResidueDetails
BPRO414-GLY434
DPRO414-GLY434

site_idSWS_FT_FI11
Number of Residues40
DetailsTRANSMEM: Helical; Name=9 => ECO:0000255
ChainResidueDetails
BVAL457-SER477
DVAL457-SER477

site_idSWS_FT_FI12
Number of Residues40
DetailsTRANSMEM: Helical; Name=10 => ECO:0000255
ChainResidueDetails
BSER491-VAL511
DSER491-VAL511

site_idSWS_FT_FI13
Number of Residues40
DetailsTRANSMEM: Helical; Name=11 => ECO:0000255
ChainResidueDetails
BVAL532-VAL552
DVAL532-VAL552

site_idSWS_FT_FI14
Number of Residues40
DetailsTRANSMEM: Helical; Name=12 => ECO:0000255
ChainResidueDetails
BVAL582-ILE602
DVAL582-ILE602

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9D687
ChainResidueDetails
BSER17
BSER627
DSER17
DSER627

site_idSWS_FT_FI16
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN158
DASN368
BASN182
BASN258
BASN354
BASN368
DASN158
DASN182
DASN258
DASN354

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PDB entries from 2024-07-17

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