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8I91

ACE2-SIT1 complex bound with proline

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0001817biological_processregulation of cytokine production
A0002003biological_processangiotensin maturation
A0003051biological_processangiotensin-mediated drinking behavior
A0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
A0004175molecular_functionendopeptidase activity
A0004180molecular_functioncarboxypeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008241molecular_functionpeptidyl-dipeptidase activity
A0008270molecular_functionzinc ion binding
A0009986cellular_componentcell surface
A0015827biological_processtryptophan transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0019058biological_processviral life cycle
A0019065biological_processreceptor-mediated endocytosis of virus by host cell
A0019229biological_processregulation of vasoconstriction
A0022898biological_processregulation of transmembrane transporter activity
A0030666cellular_componentendocytic vesicle membrane
A0031526cellular_componentbrush border membrane
A0042127biological_processregulation of cell population proliferation
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0045121cellular_componentmembrane raft
A0046718biological_processsymbiont entry into host cell
A0046813biological_processreceptor-mediated virion attachment to host cell
A0046872molecular_functionmetal ion binding
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050727biological_processregulation of inflammatory response
A0051957biological_processpositive regulation of amino acid transport
A0060135biological_processmaternal process involved in female pregnancy
A0060452biological_processpositive regulation of cardiac muscle contraction
A0061025biological_processmembrane fusion
A0070062cellular_componentextracellular exosome
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0097746biological_processblood vessel diameter maintenance
A0098670biological_processentry receptor-mediated virion attachment to host cell
A1903598biological_processpositive regulation of gap junction assembly
A1903779biological_processregulation of cardiac conduction
A1905737biological_processpositive regulation of L-proline import across plasma membrane
A2000272biological_processnegative regulation of signaling receptor activity
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0005298molecular_functionproline:sodium symporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006865biological_processamino acid transport
B0015171molecular_functionamino acid transmembrane transporter activity
B0015175molecular_functionneutral L-amino acid transmembrane transporter activity
B0015188molecular_functionL-isoleucine transmembrane transporter activity
B0015193molecular_functionL-proline transmembrane transporter activity
B0015199molecular_functionamino-acid betaine transmembrane transporter activity
B0015293molecular_functionsymporter activity
B0015370molecular_functionsolute:sodium symporter activity
B0015816biological_processglycine transport
B0015824biological_processproline transport
B0015838biological_processamino-acid betaine transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0022857molecular_functiontransmembrane transporter activity
B0035725biological_processsodium ion transmembrane transport
B0089718biological_processamino acid import across plasma membrane
B0150104biological_processtransport across blood-brain barrier
B1903804biological_processglycine import across plasma membrane
B1903806biological_processL-isoleucine import across plasma membrane
B1904271biological_processL-proline import across plasma membrane
B1905647biological_processproline import across plasma membrane
C0001618molecular_functionvirus receptor activity
C0001817biological_processregulation of cytokine production
C0002003biological_processangiotensin maturation
C0003051biological_processangiotensin-mediated drinking behavior
C0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
C0004175molecular_functionendopeptidase activity
C0004180molecular_functioncarboxypeptidase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005788cellular_componentendoplasmic reticulum lumen
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006508biological_processproteolysis
C0008237molecular_functionmetallopeptidase activity
C0008241molecular_functionpeptidyl-dipeptidase activity
C0008270molecular_functionzinc ion binding
C0009986cellular_componentcell surface
C0015827biological_processtryptophan transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0019058biological_processviral life cycle
C0019065biological_processreceptor-mediated endocytosis of virus by host cell
C0019229biological_processregulation of vasoconstriction
C0022898biological_processregulation of transmembrane transporter activity
C0030666cellular_componentendocytic vesicle membrane
C0031526cellular_componentbrush border membrane
C0042127biological_processregulation of cell population proliferation
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0045121cellular_componentmembrane raft
C0046718biological_processsymbiont entry into host cell
C0046813biological_processreceptor-mediated virion attachment to host cell
C0046872molecular_functionmetal ion binding
C0048662biological_processnegative regulation of smooth muscle cell proliferation
C0050727biological_processregulation of inflammatory response
C0051957biological_processpositive regulation of amino acid transport
C0060135biological_processmaternal process involved in female pregnancy
C0060452biological_processpositive regulation of cardiac muscle contraction
C0061025biological_processmembrane fusion
C0070062cellular_componentextracellular exosome
C0070373biological_processnegative regulation of ERK1 and ERK2 cascade
C0097746biological_processblood vessel diameter maintenance
C0098670biological_processentry receptor-mediated virion attachment to host cell
C1903598biological_processpositive regulation of gap junction assembly
C1903779biological_processregulation of cardiac conduction
C1905737biological_processpositive regulation of L-proline import across plasma membrane
C2000272biological_processnegative regulation of signaling receptor activity
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
D0005298molecular_functionproline:sodium symporter activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006865biological_processamino acid transport
D0015171molecular_functionamino acid transmembrane transporter activity
D0015175molecular_functionneutral L-amino acid transmembrane transporter activity
D0015188molecular_functionL-isoleucine transmembrane transporter activity
D0015193molecular_functionL-proline transmembrane transporter activity
D0015199molecular_functionamino-acid betaine transmembrane transporter activity
D0015293molecular_functionsymporter activity
D0015370molecular_functionsolute:sodium symporter activity
D0015816biological_processglycine transport
D0015824biological_processproline transport
D0015838biological_processamino-acid betaine transport
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0022857molecular_functiontransmembrane transporter activity
D0035725biological_processsodium ion transmembrane transport
D0089718biological_processamino acid import across plasma membrane
D0150104biological_processtransport across blood-brain barrier
D1903804biological_processglycine import across plasma membrane
D1903806biological_processL-isoleucine import across plasma membrane
D1904271biological_processL-proline import across plasma membrane
D1905647biological_processproline import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ
ChainResidueDetails
ATHR371-GLN380

site_idPS00610
Number of Residues15
DetailsNA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcqmYGGGsF
ChainResidueDetails
BTRP29-PHE43

site_idPS00754
Number of Residues21
DetailsNA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLfhSFQdpLPWsvCplngNH
ChainResidueDetails
BTYR112-HIS132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues184
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BMET1-ARG5
DARG187-LYS194
DALA263-ALA276
DTHR411-GLU431
DARG487-TYR504
DGLY576-ALA592
BALA64-THR79
BARG187-LYS194
BALA263-ALA276
BTHR411-GLU431
BARG487-TYR504
BGLY576-ALA592
DMET1-ARG5
DALA64-THR79

site_idSWS_FT_FI2
Number of Residues40
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
BPRO6-GLY26
DPRO6-GLY26

site_idSWS_FT_FI3
Number of Residues470
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BASN27-SER42
DTYR298-GLN389
DGLY453-ALA465
DSER526-TYR554
BTYR101-GLY165
BTHR216-TRP241
BTYR298-GLN389
BGLY453-ALA465
BSER526-TYR554
DASN27-SER42
DTYR101-GLY165
DTHR216-TRP241

site_idSWS_FT_FI4
Number of Residues40
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
BPHE43-LEU63
DPHE43-LEU63

site_idSWS_FT_FI5
Number of Residues40
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
BILE80-MET100
DILE80-MET100

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
BVAL166-LEU186
DVAL166-LEU186
ALYS481
CARG169
CTRP477
CLYS481

site_idSWS_FT_FI7
Number of Residues40
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
BVAL195-LEU215
DVAL195-LEU215
ATYR515
CARG273
CHIS345
CTYR515

site_idSWS_FT_FI8
Number of Residues40
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
BILE242-PHE262
DILE242-PHE262
AGLU402
CHIS374
CHIS378
CGLU402

site_idSWS_FT_FI9
Number of Residues40
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
BILE277-ILE297
DILE277-ILE297

site_idSWS_FT_FI10
Number of Residues40
DetailsTRANSMEM: Helical; Name=8 => ECO:0000255
ChainResidueDetails
BLEU390-ASN410
DLEU390-ASN410

site_idSWS_FT_FI11
Number of Residues40
DetailsTRANSMEM: Helical; Name=9 => ECO:0000255
ChainResidueDetails
BALA432-ALA452
DALA432-ALA452
CASN53
CASN322

site_idSWS_FT_FI12
Number of Residues40
DetailsTRANSMEM: Helical; Name=10 => ECO:0000255
ChainResidueDetails
BTHR466-LEU486
DTHR466-LEU486

site_idSWS_FT_FI13
Number of Residues40
DetailsTRANSMEM: Helical; Name=11 => ECO:0000255
ChainResidueDetails
BTRP505-LEU525
DTRP505-LEU525
CASN103
CASN432

site_idSWS_FT_FI14
Number of Residues40
DetailsTRANSMEM: Helical; Name=12 => ECO:0000255
ChainResidueDetails
BALA555-LEU575
DALA555-LEU575

site_idSWS_FT_FI15
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN131
BASN357
DASN131
DASN357

site_idSWS_FT_FI16
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36876523
ChainResidueDetails
ALYS788
CLYS788

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PDB entries from 2024-07-17

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