8I6J
The focused refinement of CCT3-PhLP2A from TRiC-PhLP2A complex in the open state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0002199 | cellular_component | zona pellucida receptor complex |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005832 | cellular_component | chaperonin-containing T-complex |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005874 | cellular_component | microtubule |
| C | 0006457 | biological_process | protein folding |
| C | 0007339 | biological_process | binding of sperm to zona pellucida |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0032212 | biological_process | positive regulation of telomere maintenance via telomerase |
| C | 0044183 | molecular_function | protein folding chaperone |
| C | 0044297 | cellular_component | cell body |
| C | 0050821 | biological_process | protein stabilization |
| C | 0051082 | molecular_function | unfolded protein binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0140662 | molecular_function | ATP-dependent protein folding chaperone |
| C | 1904871 | biological_process | positive regulation of protein localization to Cajal body |
| C | 1904874 | biological_process | positive regulation of telomerase RNA localization to Cajal body |
| Q | 0001525 | biological_process | angiogenesis |
| Q | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| Q | 0005515 | molecular_function | protein binding |
| Q | 0005654 | cellular_component | nucleoplasm |
| Q | 0005737 | cellular_component | cytoplasm |
| Q | 0005783 | cellular_component | endoplasmic reticulum |
| Q | 0005829 | cellular_component | cytosol |
| Q | 0006457 | biological_process | protein folding |
| Q | 0006915 | biological_process | apoptotic process |
| Q | 0010628 | biological_process | positive regulation of gene expression |
| Q | 0030036 | biological_process | actin cytoskeleton organization |
| Q | 0032991 | cellular_component | protein-containing complex |
| Q | 0043184 | molecular_function | vascular endothelial growth factor receptor 2 binding |
| Q | 0044183 | molecular_function | protein folding chaperone |
| Q | 0045766 | biological_process | positive regulation of angiogenesis |
| Q | 0048471 | cellular_component | perinuclear region of cytoplasm |
| Q | 0050730 | biological_process | regulation of peptidyl-tyrosine phosphorylation |
| Q | 0050821 | biological_process | protein stabilization |
| Q | 0097356 | cellular_component | perinucleolar compartment |
| Q | 1903333 | biological_process | negative regulation of protein folding |
| Q | 2000059 | biological_process | negative regulation of ubiquitin-dependent protein catabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00750 |
| Number of Residues | 13 |
| Details | TCP1_1 Chaperonins TCP-1 signature 1. RTcLGPkSmmKML |
| Chain | Residue | Details |
| C | ARG38-LEU50 |
| site_id | PS00751 |
| Number of Residues | 17 |
| Details | TCP1_2 Chaperonins TCP-1 signature 2. MTNDGNAILreIqVqHP |
| Chain | Residue | Details |
| C | MET59-PRO75 |
| site_id | PS00995 |
| Number of Residues | 9 |
| Details | TCP1_3 Chaperonins TCP-1 signature 3. QDeeVGDGT |
| Chain | Residue | Details |
| C | GLN87-THR95 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:26059764 |
| Chain | Residue | Details |
| Q | MET1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| Q | SER43 | |
| C | SER243 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| Q | SER234 | |
| Q | SER236 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | LYS222 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| C | SER244 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | TYR247 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER252 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | THR430 | |
| C | THR459 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS15 | |
| C | LYS248 | |
| C | LYS249 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| C | LYS381 |
