8I6J

The focused refinement of CCT3-PhLP2A from TRiC-PhLP2A complex in the open state

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0002199	cellular_component	zona pellucida receptor complex
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005832	cellular_component	chaperonin-containing T-complex
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0006457	biological_process	protein folding
C	0007339	biological_process	binding of sperm to zona pellucida
C	0032212	biological_process	positive regulation of telomere maintenance via telomerase
C	0044183	molecular_function	protein folding chaperone
C	0044297	cellular_component	cell body
C	0050821	biological_process	protein stabilization
C	0051082	molecular_function	unfolded protein binding
C	0061077	biological_process	chaperone-mediated protein folding
C	0070062	cellular_component	extracellular exosome
C	1904851	biological_process	positive regulation of establishment of protein localization to telomere
C	1904871	biological_process	positive regulation of protein localization to Cajal body
C	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
Q	0001525	biological_process	angiogenesis
Q	0001938	biological_process	positive regulation of endothelial cell proliferation
Q	0005515	molecular_function	protein binding
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005783	cellular_component	endoplasmic reticulum
Q	0005829	cellular_component	cytosol
Q	0006457	biological_process	protein folding
Q	0006915	biological_process	apoptotic process
Q	0010628	biological_process	positive regulation of gene expression
Q	0030036	biological_process	actin cytoskeleton organization
Q	0032991	cellular_component	protein-containing complex
Q	0043184	molecular_function	vascular endothelial growth factor receptor 2 binding
Q	0044183	molecular_function	protein folding chaperone
Q	0045766	biological_process	positive regulation of angiogenesis
Q	0048471	cellular_component	perinuclear region of cytoplasm
Q	0050730	biological_process	regulation of peptidyl-tyrosine phosphorylation
Q	0050821	biological_process	protein stabilization
Q	0061077	biological_process	chaperone-mediated protein folding
Q	0097356	cellular_component	perinucleolar compartment
Q	1903645	biological_process	negative regulation of chaperone-mediated protein folding
Q	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00750
Number of Residues	13
Details	TCP1_1 Chaperonins TCP-1 signature 1. RTcLGPkSmmKML

Chain	Residue	Details
C	ARG38-LEU50

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site_id	PS00751
Number of Residues	17
Details	TCP1_2 Chaperonins TCP-1 signature 2. MTNDGNAILreIqVqHP

Chain	Residue	Details
C	MET59-PRO75

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site_id	PS00995
Number of Residues	9
Details	TCP1_3 Chaperonins TCP-1 signature 3. QDeeVGDGT

Chain	Residue	Details
C	GLN87-THR95

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.5, ECO:0007744|PubMed:19413330

Chain	Residue	Details
C	MET1

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER11
C	SER243

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P80318

Chain	Residue	Details
C	SER170
Q	SER236

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS222

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
C	SER244

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	TYR247

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	SER252

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	THR430
C	THR459

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS15
C	LYS248
C	LYS249

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211

Chain	Residue	Details
C	LYS381

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