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8I48

Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in closed state

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005267molecular_functionpotassium channel activity
A0005272molecular_functionsodium channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006814biological_processsodium ion transport
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0071805biological_processpotassium ion transmembrane transport
A1902495cellular_componenttransmembrane transporter complex
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005267molecular_functionpotassium channel activity
B0005272molecular_functionsodium channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006814biological_processsodium ion transport
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0071805biological_processpotassium ion transmembrane transport
B1902495cellular_componenttransmembrane transporter complex
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005267molecular_functionpotassium channel activity
C0005272molecular_functionsodium channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006814biological_processsodium ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
C0035725biological_processsodium ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0071805biological_processpotassium ion transmembrane transport
C1902495cellular_componenttransmembrane transporter complex
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005267molecular_functionpotassium channel activity
D0005272molecular_functionsodium channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006814biological_processsodium ion transport
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0035725biological_processsodium ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0071805biological_processpotassium ion transmembrane transport
D1902495cellular_componenttransmembrane transporter complex
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005267molecular_functionpotassium channel activity
E0005272molecular_functionsodium channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006814biological_processsodium ion transport
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
E0035725biological_processsodium ion transmembrane transport
E0042802molecular_functionidentical protein binding
E0071805biological_processpotassium ion transmembrane transport
E1902495cellular_componenttransmembrane transporter complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues370
DetailsTRANSMEM: Helical
ChainResidueDetails
ATYR194-PHE216
BTYR194-PHE216
BSER220-THR244
BTHR253-VAL281
ETYR194-PHE216
ESER220-THR244
ETHR253-VAL281
ASER220-THR244
ATHR253-VAL281
CTYR194-PHE216
CSER220-THR244
CTHR253-VAL281
DTYR194-PHE216
DSER220-THR244
DTHR253-VAL281

site_idSWS_FT_FI2
Number of Residues20
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ATRP217-THR219
EGLU282-GLN284
AGLU282-GLN284
CTRP217-THR219
CGLU282-GLN284
DTRP217-THR219
DGLU282-GLN284
BTRP217-THR219
BGLU282-GLN284
ETRP217-THR219

site_idSWS_FT_FI3
Number of Residues35
DetailsTOPO_DOM: Periplasmic => ECO:0000255
ChainResidueDetails
AASN245-MET252
CASN245-MET252
DASN245-MET252
BASN245-MET252
EASN245-MET252

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PDB entries from 2024-11-20

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