Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

8I0N

Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 (Local refine)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0001933biological_processnegative regulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
A0002031biological_processG protein-coupled receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006355biological_processregulation of DNA-templated transcription
A0006511biological_processubiquitin-dependent protein catabolic process
A0006897biological_processendocytosis
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007600biological_processsensory perception
A0008277biological_processregulation of G protein-coupled receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0009968biological_processnegative regulation of signal transduction
A0014069cellular_componentpostsynaptic density
A0016323cellular_componentbasolateral plasma membrane
A0019899molecular_functionenzyme binding
A0030276molecular_functionclathrin binding
A0030331molecular_functionnuclear estrogen receptor binding
A0031143cellular_componentpseudopodium
A0031396biological_processregulation of protein ubiquitination
A0031398biological_processpositive regulation of protein ubiquitination
A0031410cellular_componentcytoplasmic vesicle
A0031691molecular_functionalpha-1A adrenergic receptor binding
A0031692molecular_functionalpha-1B adrenergic receptor binding
A0031762molecular_functionfollicle-stimulating hormone receptor binding
A0031896molecular_functionV2 vasopressin receptor binding
A0032960biological_processregulation of inositol trisphosphate biosynthetic process
A0034260biological_processnegative regulation of GTPase activity
A0035612molecular_functionAP-2 adaptor complex binding
A0035615molecular_functionclathrin-cargo adaptor activity
A0042699biological_processfollicle-stimulating hormone signaling pathway
A0043066biological_processnegative regulation of apoptotic process
A0043197cellular_componentdendritic spine
A0043278biological_processresponse to morphine
A0043410biological_processpositive regulation of MAPK cascade
A0043524biological_processnegative regulation of neuron apoptotic process
A0044325molecular_functiontransmembrane transporter binding
A0045211cellular_componentpostsynaptic membrane
A0045309molecular_functionprotein phosphorylated amino acid binding
A0045746biological_processnegative regulation of Notch signaling pathway
A0045880biological_processpositive regulation of smoothened signaling pathway
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050975biological_processsensory perception of touch
A0051219molecular_functionphosphoprotein binding
A0060090molecular_functionmolecular adaptor activity
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0097499biological_processprotein localization to non-motile cilium
A0098978cellular_componentglutamatergic synapse
A1902533biological_processpositive regulation of intracellular signal transduction
A1990763molecular_functionarrestin family protein binding
B0001664molecular_functionG protein-coupled receptor binding
B0001933biological_processnegative regulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
B0002031biological_processG protein-coupled receptor internalization
B0002092biological_processpositive regulation of receptor internalization
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005905cellular_componentclathrin-coated pit
B0006355biological_processregulation of DNA-templated transcription
B0006511biological_processubiquitin-dependent protein catabolic process
B0006897biological_processendocytosis
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
B0007600biological_processsensory perception
B0008277biological_processregulation of G protein-coupled receptor signaling pathway
B0008284biological_processpositive regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0009968biological_processnegative regulation of signal transduction
B0014069cellular_componentpostsynaptic density
B0016323cellular_componentbasolateral plasma membrane
B0019899molecular_functionenzyme binding
B0030276molecular_functionclathrin binding
B0030331molecular_functionnuclear estrogen receptor binding
B0031143cellular_componentpseudopodium
B0031396biological_processregulation of protein ubiquitination
B0031398biological_processpositive regulation of protein ubiquitination
B0031410cellular_componentcytoplasmic vesicle
B0031691molecular_functionalpha-1A adrenergic receptor binding
B0031692molecular_functionalpha-1B adrenergic receptor binding
B0031762molecular_functionfollicle-stimulating hormone receptor binding
B0031896molecular_functionV2 vasopressin receptor binding
B0032960biological_processregulation of inositol trisphosphate biosynthetic process
B0034260biological_processnegative regulation of GTPase activity
B0035612molecular_functionAP-2 adaptor complex binding
B0035615molecular_functionclathrin-cargo adaptor activity
B0042699biological_processfollicle-stimulating hormone signaling pathway
B0043066biological_processnegative regulation of apoptotic process
B0043197cellular_componentdendritic spine
B0043278biological_processresponse to morphine
B0043410biological_processpositive regulation of MAPK cascade
B0043524biological_processnegative regulation of neuron apoptotic process
B0044325molecular_functiontransmembrane transporter binding
B0045211cellular_componentpostsynaptic membrane
B0045309molecular_functionprotein phosphorylated amino acid binding
B0045746biological_processnegative regulation of Notch signaling pathway
B0045880biological_processpositive regulation of smoothened signaling pathway
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0050975biological_processsensory perception of touch
B0051219molecular_functionphosphoprotein binding
B0060090molecular_functionmolecular adaptor activity
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0097499biological_processprotein localization to non-motile cilium
B0098978cellular_componentglutamatergic synapse
B1902533biological_processpositive regulation of intracellular signal transduction
B1990763molecular_functionarrestin family protein binding
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR204-HIS210
LTYR193-HIS199

site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
APHE61-LEU79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues82
DetailsRegion: {"description":"Interaction with CHRM2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues22
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

251801

PDB entries from 2026-04-08

PDB statisticsPDBj update infoContact PDBjnumon