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8I03

Cryo-EM structure of the SIN3L complex from S. pombe

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000785cellular_componentchromatin
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005721cellular_componentpericentric heterochromatin
A0006355biological_processregulation of DNA-templated transcription
A0031508biological_processpericentric heterochromatin formation
A0033698cellular_componentRpd3L complex
A0051301biological_processcell division
A0070210cellular_componentRpd3L-Expanded complex
A0070822cellular_componentSin3-type complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000785cellular_componentchromatin
B0003714molecular_functiontranscription corepressor activity
B0005634cellular_componentnucleus
B0005829cellular_componentcytosol
B0006303biological_processdouble-strand break repair via nonhomologous end joining
B0006355biological_processregulation of DNA-templated transcription
B0033698cellular_componentRpd3L complex
B0045815biological_processtranscription initiation-coupled chromatin remodeling
B0070210cellular_componentRpd3L-Expanded complex
B0070822cellular_componentSin3-type complex
C0000785cellular_componentchromatin
C0004407molecular_functionhistone deacetylase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005730cellular_componentnucleolus
C0005829cellular_componentcytosol
C0006325biological_processchromatin organization
C0010468biological_processregulation of gene expression
C0016787molecular_functionhydrolase activity
C0031078molecular_functionhistone H3K14 deacetylase activity
C0031507biological_processheterochromatin formation
C0032129molecular_functionhistone H3K9 deacetylase activity
C0032221cellular_componentRpd3S complex
C0033558molecular_functionprotein lysine deacetylase activity
C0033698cellular_componentRpd3L complex
C0034739molecular_functionhistone H4K16 deacetylase activity
C0040029biological_processepigenetic regulation of gene expression
C0045815biological_processtranscription initiation-coupled chromatin remodeling
C0070210cellular_componentRpd3L-Expanded complex
C0140937molecular_functionhistone H4K12 deacetylase activity
C0180032molecular_functionhistone H4K5 deacetylase activity
C0180033molecular_functionhistone H4K48 deacetylase activity
D0000785cellular_componentchromatin
D0004407molecular_functionhistone deacetylase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005730cellular_componentnucleolus
D0005829cellular_componentcytosol
D0006325biological_processchromatin organization
D0010468biological_processregulation of gene expression
D0016787molecular_functionhydrolase activity
D0031078molecular_functionhistone H3K14 deacetylase activity
D0031507biological_processheterochromatin formation
D0032129molecular_functionhistone H3K9 deacetylase activity
D0032221cellular_componentRpd3S complex
D0033558molecular_functionprotein lysine deacetylase activity
D0033698cellular_componentRpd3L complex
D0034739molecular_functionhistone H4K16 deacetylase activity
D0040029biological_processepigenetic regulation of gene expression
D0045815biological_processtranscription initiation-coupled chromatin remodeling
D0070210cellular_componentRpd3L-Expanded complex
D0140937molecular_functionhistone H4K12 deacetylase activity
D0180032molecular_functionhistone H4K5 deacetylase activity
D0180033molecular_functionhistone H4K48 deacetylase activity
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0006325biological_processchromatin organization
E0010468biological_processregulation of gene expression
E0033698cellular_componentRpd3L complex
E0042826molecular_functionhistone deacetylase binding
E0045815biological_processtranscription initiation-coupled chromatin remodeling
E0070210cellular_componentRpd3L-Expanded complex
E0070822cellular_componentSin3-type complex
F0003674molecular_functionmolecular_function
F0005634cellular_componentnucleus
F0005829cellular_componentcytosol
F0006325biological_processchromatin organization
F0006357biological_processregulation of transcription by RNA polymerase II
F0033698cellular_componentRpd3L complex
F0070210cellular_componentRpd3L-Expanded complex
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0000785cellular_componentchromatin
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0006325biological_processchromatin organization
G0010468biological_processregulation of gene expression
G0033698cellular_componentRpd3L complex
G0042826molecular_functionhistone deacetylase binding
G0070210cellular_componentRpd3L-Expanded complex
G0070822cellular_componentSin3-type complex
H0000785cellular_componentchromatin
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006325biological_processchromatin organization
H0006355biological_processregulation of DNA-templated transcription
H0033698cellular_componentRpd3L complex
H0035064molecular_functionmethylated histone binding
H0035267cellular_componentNuA4 histone acetyltransferase complex
H0046872molecular_functionmetal ion binding
H0070210cellular_componentRpd3L-Expanded complex
H0140861biological_processDNA repair-dependent chromatin remodeling
I0003674molecular_functionmolecular_function
I0005634cellular_componentnucleus
I0006325biological_processchromatin organization
I0033698cellular_componentRpd3L complex
I0045815biological_processtranscription initiation-coupled chromatin remodeling
I0070210cellular_componentRpd3L-Expanded complex
J0000510molecular_functionH3-H4 histone complex chaperone activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005730cellular_componentnucleolus
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006325biological_processchromatin organization
J0006338biological_processchromatin remodeling
J0006355biological_processregulation of DNA-templated transcription
J0032221cellular_componentRpd3S complex
J0033698cellular_componentRpd3L complex
J0042393molecular_functionhistone binding
J0045815biological_processtranscription initiation-coupled chromatin remodeling
J0070210cellular_componentRpd3L-Expanded complex
K0000510molecular_functionH3-H4 histone complex chaperone activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005730cellular_componentnucleolus
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0006325biological_processchromatin organization
K0006338biological_processchromatin remodeling
K0006355biological_processregulation of DNA-templated transcription
K0032221cellular_componentRpd3S complex
K0033698cellular_componentRpd3L complex
K0042393molecular_functionhistone binding
K0045815biological_processtranscription initiation-coupled chromatin remodeling
K0070210cellular_componentRpd3L-Expanded complex
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LATCstDkTIALWDL
ChainResidueDetails
JLEU297-LEU311
JLEU341-LEU355

site_idPS01359
Number of Residues44
DetailsZF_PHD_1 Zinc finger PHD-type signature. Cy.Cqqvsygqm.....................................IgCdnenCkrewFHlpCvglveppkgi...................................WyCkeC
ChainResidueDetails
HCYS251-CYS294

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues49
DetailsZN_FING: PHD-type => ECO:0000255|PROSITE-ProRule:PRU00146
ChainResidueDetails
HGLN248-LEU297
ESER223

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9UK53
ChainResidueDetails
HCYS251
HCYS253
HCYS264
HCYS269
HHIS275
HCYS278
HCYS291
HCYS294

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Histone H3K4me3 binding => ECO:0000250|UniProtKB:Q9UK53
ChainResidueDetails
HTYR250
HMET261
HASP265
HTRP273

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:18257517
ChainResidueDetails
HTYR181

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:18257517
ChainResidueDetails
HTHR183

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:18257517
ChainResidueDetails
HSER197
HSER198

224931

PDB entries from 2024-09-11

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