Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8I02

Cryo-EM structure of the SIN3S complex from S. pombe

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000785	cellular_component	chromatin
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0006325	biological_process	chromatin organization
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032221	cellular_component	Rpd3S complex
A	0045815	biological_process	transcription initiation-coupled chromatin remodeling
A	0060090	molecular_function	molecular adaptor activity
A	0070822	cellular_component	Sin3-type complex
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000785	cellular_component	chromatin
B	0004407	molecular_function	histone deacetylase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005829	cellular_component	cytosol
B	0006325	biological_process	chromatin organization
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0010468	biological_process	regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0031078	molecular_function	histone H3K14 deacetylase activity, hydrolytic mechanism
B	0031507	biological_process	heterochromatin formation
B	0032129	molecular_function	histone H3K9 deacetylase activity, hydrolytic mechanism
B	0032221	cellular_component	Rpd3S complex
B	0033558	molecular_function	protein lysine deacetylase activity
B	0033698	cellular_component	Rpd3L complex
B	0034739	molecular_function	histone H4K16 deacetylase activity, hydrolytic mechanism
B	0040029	biological_process	epigenetic regulation of gene expression
B	0045815	biological_process	transcription initiation-coupled chromatin remodeling
B	0070210	cellular_component	Rpd3L-Expanded complex
B	0140937	molecular_function	histone H4K12 deacetylase activity, hydrolytic mechanism
B	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism
B	0180032	molecular_function	histone H4K5 deacetylase activity, hydrolytic mechanism
B	0180033	molecular_function	histone H4K8 deacetylase activity, hydrolytic mechanism
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000510	molecular_function	H3-H4 histone complex chaperone activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0032221	cellular_component	Rpd3S complex
C	0033698	cellular_component	Rpd3L complex
C	0042393	molecular_function	histone binding
C	0045815	biological_process	transcription initiation-coupled chromatin remodeling
C	0070210	cellular_component	Rpd3L-Expanded complex
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005730	cellular_component	nucleolus
D	0006281	biological_process	DNA repair
D	0006325	biological_process	chromatin organization
D	0006338	biological_process	chromatin remodeling
D	0006351	biological_process	DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006974	biological_process	DNA damage response
D	0010468	biological_process	regulation of gene expression
D	0032221	cellular_component	Rpd3S complex
D	0035267	cellular_component	NuA4 histone acetyltransferase complex
D	0045815	biological_process	transcription initiation-coupled chromatin remodeling
D	0140861	biological_process	DNA repair-dependent chromatin remodeling
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005730	cellular_component	nucleolus
E	0006281	biological_process	DNA repair
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0006351	biological_process	DNA-templated transcription
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006974	biological_process	DNA damage response
E	0010468	biological_process	regulation of gene expression
E	0032221	cellular_component	Rpd3S complex
E	0035267	cellular_component	NuA4 histone acetyltransferase complex
E	0045815	biological_process	transcription initiation-coupled chromatin remodeling
E	0140861	biological_process	DNA repair-dependent chromatin remodeling
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005829	cellular_component	cytosol
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0008270	molecular_function	zinc ion binding
F	0032221	cellular_component	Rpd3S complex
F	0032991	cellular_component	protein-containing complex
F	0045815	biological_process	transcription initiation-coupled chromatin remodeling
F	0046872	molecular_function	metal ion binding
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0005634	cellular_component	nucleus
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0008270	molecular_function	zinc ion binding
G	0032221	cellular_component	Rpd3S complex
G	0032991	cellular_component	protein-containing complex
G	0045815	biological_process	transcription initiation-coupled chromatin remodeling
G	0046872	molecular_function	metal ion binding
G	0060090	molecular_function	molecular adaptor activity
G	0072686	cellular_component	mitotic spindle

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATCstDkTIALWDL

Chain	Residue	Details
C	LEU297-LEU311
C	LEU341-LEU355

site_id	PS01359
Number of Residues	44
Details	ZF_PHD_1 Zinc finger PHD-type signature. CsaChgpgnf.......................................LcCet..Cpns.FHftCidppieeknlpdda...............................WyCneC

Chain	Residue	Details
G	CYS266-CYS309
F	CYS120-CYS163

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	49
Details	Zinc finger: {"description":"PHD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	70
Details	Domain: {"description":"PAH 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00810","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	312
Details	Region: {"description":"Histone deacetylase"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	32
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	31
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	31
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	31
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	31
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	31
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	53
Details	Zinc finger: {"description":"PHD-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)