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8HZN

Mouse Pendrin bound chloride in inward state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006885biological_processregulation of pH
A0008509molecular_functionmonoatomic anion transmembrane transporter activity
A0009887biological_processanimal organ morphogenesis
A0015106molecular_functionbicarbonate transmembrane transporter activity
A0015108molecular_functionchloride transmembrane transporter activity
A0015111molecular_functioniodide transmembrane transporter activity
A0015116molecular_functionsulfate transmembrane transporter activity
A0015698biological_processinorganic anion transport
A0015701biological_processbicarbonate transport
A0015705biological_processiodide transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0019531molecular_functionoxalate transmembrane transporter activity
A0019532biological_processoxalate transport
A0031526cellular_componentbrush border membrane
A0032880biological_processregulation of protein localization
A0070062cellular_componentextracellular exosome
A0098656biological_processmonoatomic anion transmembrane transport
A0140900molecular_functionchloride:bicarbonate antiporter activity
A1902358biological_processsulfate transmembrane transport
A1902476biological_processchloride transmembrane transport
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006885biological_processregulation of pH
B0008509molecular_functionmonoatomic anion transmembrane transporter activity
B0009887biological_processanimal organ morphogenesis
B0015106molecular_functionbicarbonate transmembrane transporter activity
B0015108molecular_functionchloride transmembrane transporter activity
B0015111molecular_functioniodide transmembrane transporter activity
B0015116molecular_functionsulfate transmembrane transporter activity
B0015698biological_processinorganic anion transport
B0015701biological_processbicarbonate transport
B0015705biological_processiodide transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0019531molecular_functionoxalate transmembrane transporter activity
B0019532biological_processoxalate transport
B0031526cellular_componentbrush border membrane
B0032880biological_processregulation of protein localization
B0070062cellular_componentextracellular exosome
B0098656biological_processmonoatomic anion transmembrane transport
B0140900molecular_functionchloride:bicarbonate antiporter activity
B1902358biological_processsulfate transmembrane transport
B1902476biological_processchloride transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS01130
Number of Residues22
DetailsSLC26A SLC26A transporters signature. VqFGLYSAffpiLTYfvfGTSR
ChainResidueDetails
AVAL113-ARG134

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues800
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ASP87
BARG213-PRO218
BVAL285-ARG295
BSER366-GLU384
BGLU443-SER448
BTHR508-SER780
AGLY131-HIS135
AARG213-PRO218
AVAL285-ARG295
ASER366-GLU384
AGLU443-SER448
ATHR508-SER780
BMET1-ASP87
BGLY131-HIS135

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AILE88-LEU108
AVAL422-LEU442
AVAL449-PRO469
AILE487-LEU507
BILE88-LEU108
BALA110-PHE130
BILE136-ALA156
BLEU192-VAL212
BLEU219-VAL239
BILE264-ALA284
BILE296-GLY316
AALA110-PHE130
BLEU345-VAL365
BPHE385-THR405
BVAL422-LEU442
BVAL449-PRO469
BILE487-LEU507
AILE136-ALA156
ALEU192-VAL212
ALEU219-VAL239
AILE264-ALA284
AILE296-GLY316
ALEU345-VAL365
APHE385-THR405

site_idSWS_FT_FI3
Number of Residues232
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AALA109
BALA317-GLY344
BALA406-GLN421
BARG470-CYS486
APRO157-THR191
ALEU240-ASN263
AALA317-GLY344
AALA406-GLN421
AARG470-CYS486
BALA109
BPRO157-THR191
BLEU240-ASN263

220113

PDB entries from 2024-05-22

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