Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8HWL

Human Pyruvate Carboxylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004736	molecular_function	pyruvate carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006090	biological_process	pyruvate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006629	biological_process	lipid metabolic process
A	0006734	biological_process	obsolete NADH metabolic process
A	0006739	biological_process	NADP+ metabolic process
A	0009374	molecular_function	biotin binding
A	0010629	biological_process	negative regulation of gene expression
A	0016874	molecular_function	ligase activity
A	0019074	biological_process	viral RNA genome packaging
A	0019076	biological_process	viral release from host cell
A	0042802	molecular_function	identical protein binding
A	0044281	biological_process	small molecule metabolic process
A	0044794	biological_process	positive regulation by host of viral process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004736	molecular_function	pyruvate carboxylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006090	biological_process	pyruvate metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006629	biological_process	lipid metabolic process
B	0006734	biological_process	obsolete NADH metabolic process
B	0006739	biological_process	NADP+ metabolic process
B	0009374	molecular_function	biotin binding
B	0010629	biological_process	negative regulation of gene expression
B	0016874	molecular_function	ligase activity
B	0019074	biological_process	viral RNA genome packaging
B	0019076	biological_process	viral release from host cell
B	0042802	molecular_function	identical protein binding
B	0044281	biological_process	small molecule metabolic process
B	0044794	biological_process	positive regulation by host of viral process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004736	molecular_function	pyruvate carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006090	biological_process	pyruvate metabolic process
C	0006094	biological_process	gluconeogenesis
C	0006629	biological_process	lipid metabolic process
C	0006734	biological_process	obsolete NADH metabolic process
C	0006739	biological_process	NADP+ metabolic process
C	0009374	molecular_function	biotin binding
C	0010629	biological_process	negative regulation of gene expression
C	0016874	molecular_function	ligase activity
C	0019074	biological_process	viral RNA genome packaging
C	0019076	biological_process	viral release from host cell
C	0042802	molecular_function	identical protein binding
C	0044281	biological_process	small molecule metabolic process
C	0044794	biological_process	positive regulation by host of viral process
C	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004736	molecular_function	pyruvate carboxylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006090	biological_process	pyruvate metabolic process
E	0006094	biological_process	gluconeogenesis
E	0006629	biological_process	lipid metabolic process
E	0006734	biological_process	obsolete NADH metabolic process
E	0006739	biological_process	NADP+ metabolic process
E	0009374	molecular_function	biotin binding
E	0010629	biological_process	negative regulation of gene expression
E	0016874	molecular_function	ligase activity
E	0019074	biological_process	viral RNA genome packaging
E	0019076	biological_process	viral release from host cell
E	0042802	molecular_function	identical protein binding
E	0044281	biological_process	small molecule metabolic process
E	0044794	biological_process	positive regulation by host of viral process
E	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GQpLcvLsAMKMetvVtS

Chain	Residue	Details
A	GLY1134-SER1151

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	788
Details	Domain: {"description":"ATP-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU00409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1076
Details	Domain: {"description":"Pyruvate carboxyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01151","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	276
Details	Domain: {"description":"Biotinyl-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18297087","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"description":"via carbamate group","evidences":[{"source":"PubMed","id":"18297087","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	56
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q05920","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"18297087","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P52873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"N6-biotinyllysine","evidences":[{"source":"PROSITE-ProRule","id":"PRU01066","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"6548474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7918683","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)