8HVT
Structure of the human CLC-7/Ostm1 complex reveals a novel state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005247 | molecular_function | voltage-gated chloride channel activity |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0030321 | biological_process | transepithelial chloride transport |
| A | 0034707 | cellular_component | chloride channel complex |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| C | 0005247 | molecular_function | voltage-gated chloride channel activity |
| C | 0005254 | molecular_function | chloride channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005764 | cellular_component | lysosome |
| C | 0005765 | cellular_component | lysosomal membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006821 | biological_process | chloride transport |
| C | 0015108 | molecular_function | chloride transmembrane transporter activity |
| C | 0015297 | molecular_function | antiporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0030321 | biological_process | transepithelial chloride transport |
| C | 0034707 | cellular_component | chloride channel complex |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0055085 | biological_process | transmembrane transport |
| C | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 504 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| B | ALA32-PRO284 | |
| D | ALA32-PRO284 | |
| C | MET1-ARG126 | |
| C | ILE598-THR805 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | VAL285-LEU305 | |
| A | TYR579-PHE597 | |
| C | TRP127-ILE159 | |
| C | PHE174-ILE197 | |
| C | ARG223-GLY241 | |
| C | GLU247-GLY264 | |
| C | PHE322-VAL341 | |
| C | ILE375-ARG405 | |
| C | PRO410-ILE432 | |
| C | PRO487-LEU507 | |
| C | GLY512-LEU535 | |
| D | VAL285-LEU305 | |
| C | TYR579-PHE597 | |
| A | ARG223-GLY241 | |
| A | GLU247-GLY264 | |
| A | PHE322-VAL341 | |
| A | ILE375-ARG405 | |
| A | PRO410-ILE432 | |
| A | PRO487-LEU507 | |
| A | GLY512-LEU535 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 56 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | HIS306-ASN334 | |
| C | THR563-THR574 | |
| D | HIS306-ASN334 | |
| A | PRO304-LEU312 | |
| A | GLY545-ILE559 | |
| A | THR563-THR574 | |
| C | ILE206-LEU213 | |
| C | PHE288-ALA300 | |
| C | PRO304-LEU312 | |
| C | GLY545-ILE559 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER322 | |
| D | SER322 | |
| C | VAL560-MET562 | |
| C | SER575-THR578 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER325 | |
| C | THR783 | |
| D | SER325 | |
| A | TYR602 | |
| A | HIS658 | |
| A | THR783 | |
| C | SER204 | |
| C | PHE514 | |
| C | TYR602 | |
| C | HIS658 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| B | SER333 | |
| D | SER333 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN93 | |
| B | ASN274 | |
| D | ASN93 | |
| D | ASN128 | |
| D | ASN135 | |
| D | ASN163 | |
| D | ASN177 | |
| D | ASN184 | |
| D | ASN194 | |
| D | ASN216 | |
| D | ASN263 | |
| B | ASN128 | |
| D | ASN274 | |
| B | ASN135 | |
| B | ASN163 | |
| B | ASN177 | |
| B | ASN184 | |
| B | ASN194 | |
| B | ASN216 | |
| B | ASN263 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O70496 |
| Chain | Residue | Details |
| A | SER9 | |
| C | SER9 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER60 | |
| C | SER60 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER801 | |
| C | SER801 |
