8HVH

Cryo-EM structure of ABC transporter ABCC3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006855	biological_process	xenobiotic transmembrane transport
A	0006869	biological_process	lipid transport
A	0008559	molecular_function	ABC-type xenobiotic transporter activity
A	0009925	cellular_component	basal plasma membrane
A	0015164	molecular_function	glucuronoside transmembrane transporter activity
A	0015431	molecular_function	ABC-type glutathione S-conjugate transporter activity
A	0015432	molecular_function	ABC-type bile acid transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015779	biological_process	glucuronoside transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022857	molecular_function	transmembrane transporter activity
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0043225	molecular_function	ATPase-coupled inorganic anion transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0071714	molecular_function	icosanoid transmembrane transporter activity
A	0071716	biological_process	leukotriene transport
A	0098656	biological_process	monoatomic anion transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
A	0150104	biological_process	transport across blood-brain barrier

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRVSLARAV

Chain	Residue	Details
A	LEU751-VAL765
A	LEU1426-LEU1440

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	138
Details	TOPO_DOM: Extracellular => ECO:0000250

Chain	Residue	Details
A	MET1-PHE32
A	LEU95-ARG99
A	SER154-PHE171
A	LEU324-GLY349
A	LEU448-PRO450
A	VAL555-ASN576
A	ALA985-LEU1021
A	SER1107
A	LEU1221-ASN1222

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	GLN33-LEU53

---

site_id	SWS_FT_FI3
Number of Residues	1015
Details	TOPO_DOM: Cytoplasmic => ECO:0000250

Chain	Residue	Details
A	LEU54-LYS73
A	LEU121-GLN132
A	LYS193-ALA302
A	TYR371-PHE426
A	LYS472-THR533
A	SER598-ALA963
A	VAL1043-PRO1085
A	TYR1129-VAL1199
A	ILE1244-ALA1527

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	MET74-GLY94

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	ALA100-THR120

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	SER133-ARG153

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	THR172-GLU192

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	LEU303-LEU323

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	PHE350-TYR370

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	TRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	LEU427-ASN447

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	TRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	SER451-VAL471

---

site_id	SWS_FT_FI12
Number of Residues	20
Details	TRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	THR534-TYR554

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	TRANSMEM: Helical; Name=11 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	ILE577-VAL597

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	TRANSMEM: Helical; Name=12 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	LYS964-ALA984

---

site_id	SWS_FT_FI15
Number of Residues	20
Details	TRANSMEM: Helical; Name=13 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	GLN1022-ARG1042

---

site_id	SWS_FT_FI16
Number of Residues	20
Details	TRANSMEM: Helical; Name=14 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	VAL1086-ALA1106

---

site_id	SWS_FT_FI17
Number of Residues	20
Details	TRANSMEM: Helical; Name=15 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	THR1108-PHE1128

---

site_id	SWS_FT_FI18
Number of Residues	20
Details	TRANSMEM: Helical; Name=16 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	GLU1200-SER1220

---

site_id	SWS_FT_FI19
Number of Residues	20
Details	TRANSMEM: Helical; Name=17 => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	PRO1223-MET1243

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434

Chain	Residue	Details
A	GLY661
A	GLY1323

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER908

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER911

---

site_id	SWS_FT_FI23
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN18
A	ASN1006
A	ASN1007

---