Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8HRX

Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001618	molecular_function	virus receptor activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0006869	biological_process	lipid transport
A	0008508	molecular_function	bile acid:sodium symporter activity
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0031667	biological_process	response to nutrient levels
A	0043627	biological_process	response to estrogen
A	0045471	biological_process	response to ethanol
A	0046718	biological_process	symbiont entry into host cell
A	0055085	biological_process	transmembrane transport
A	0071466	biological_process	cellular response to xenobiotic stimulus

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	22
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	25
Details	Transmembrane: {"description":"Discontinuously helical; Name=3","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	25
Details	Transmembrane: {"description":"Discontinuously helical; Name=8","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"35545671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580629","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35580630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38233573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HRY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)