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8HRX

Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006814biological_processsodium ion transport
A0006869biological_processlipid transport
A0008508molecular_functionbile acid:sodium symporter activity
A0014070biological_processresponse to organic cyclic compound
A0015125molecular_functionbile acid transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015721biological_processbile acid and bile salt transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0031667biological_processresponse to nutrient levels
A0043627biological_processresponse to estrogen
A0045471biological_processresponse to ethanol
A0046718biological_processsymbiont entry into host cell
A0055085biological_processtransmembrane transport
A0071466biological_processcellular response to xenobiotic stimulus
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
LTYR192-HIS198

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues160
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU25-THR45
AGLY60-GLY80
ALEU91-ALA111
AILE120-ILE140
ATYR156-LEU176
AGLY191-GLY211
APRO220-LEU240
APHE283-ILE303

site_idSWS_FT_FI2
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN5
AASN11
AASN117

226707

PDB entries from 2024-10-30

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