8HIJ

The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005542	molecular_function	folic acid binding
A	0005886	cellular_component	plasma membrane
A	0006855	biological_process	xenobiotic transmembrane transport
A	0007565	biological_process	female pregnancy
A	0008514	molecular_function	organic anion transmembrane transporter activity
A	0008517	molecular_function	folic acid transmembrane transporter activity
A	0008518	molecular_function	folate:monoatomic anion antiporter activity
A	0009055	molecular_function	electron transfer activity
A	0015297	molecular_function	antiporter activity
A	0015350	molecular_function	methotrexate transmembrane transporter activity
A	0015711	biological_process	organic anion transport
A	0015884	biological_process	folic acid transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0031526	cellular_component	brush border membrane
A	0042597	cellular_component	periplasmic space
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0046655	biological_process	folic acid metabolic process
A	0046872	molecular_function	metal ion binding
A	0051180	biological_process	vitamin transport
A	0051958	biological_process	methotrexate transport
A	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
A	0071705	biological_process	nitrogen compound transport
A	0090482	molecular_function	vitamin transmembrane transporter activity
A	0098656	biological_process	monoatomic anion transmembrane transport
A	0098838	biological_process	folate transmembrane transport
A	0140360	molecular_function	cyclic-GMP-AMP transmembrane transporter activity
A	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane
A	0141111	biological_process	positive regulation of cGAS/STING signaling pathway
A	0150104	biological_process	transport across blood-brain barrier
A	1904447	biological_process	folate import across plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR194-HIS200
H	TYR208-HIS214

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP-76
A	ILE19

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site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000305

Chain	Residue	Details
A	SER24-GLY44

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site_id	SWS_FT_FI3
Number of Residues	78
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:10347183

Chain	Residue	Details
A	GLU45-PRO70
A	ALA117-GLU123
A	GLY178-ASN186
A	VAL288-ALA309
A	HIS355-SER360
A	ASP420-GLN433

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	TRANSMEM: Helical; Name=2 => ECO:0000305

Chain	Residue	Details
A	VAL71-TYR89

---

site_id	SWS_FT_FI5
Number of Residues	230
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:10347183

Chain	Residue	Details
A	LEU90-VAL95
A	ARG145-ALA159
A	LYS204-GLY259
A	LYS328-ARG333
A	LEU379-GLU394
A	LEU455-GLN591

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000305

Chain	Residue	Details
A	LEU96-VAL116

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site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000305

Chain	Residue	Details
A	LEU124-VAL144

---

site_id	SWS_FT_FI8
Number of Residues	17
Details	TRANSMEM: Helical; Name=5 => ECO:0000305

Chain	Residue	Details
A	VAL160-VAL177

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site_id	SWS_FT_FI9
Number of Residues	16
Details	TRANSMEM: Helical; Name=6 => ECO:0000305

Chain	Residue	Details
A	TYR187-LEU203

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site_id	SWS_FT_FI10
Number of Residues	27
Details	TRANSMEM: Helical; Name=7 => ECO:0000305

Chain	Residue	Details
A	ASP260-TYR287

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site_id	SWS_FT_FI11
Number of Residues	17
Details	TRANSMEM: Helical; Name=8 => ECO:0000305

Chain	Residue	Details
A	ASP310-VAL327

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site_id	SWS_FT_FI12
Number of Residues	20
Details	TRANSMEM: Helical; Name=9 => ECO:0000305

Chain	Residue	Details
A	TRP334-ALA354

---

site_id	SWS_FT_FI13
Number of Residues	17
Details	TRANSMEM: Helical; Name=10 => ECO:0000305

Chain	Residue	Details
A	SER361-PHE378

---

site_id	SWS_FT_FI14
Number of Residues	24
Details	TRANSMEM: Helical; Name=11 => ECO:0000305

Chain	Residue	Details
A	LEU395-SER419

---

site_id	SWS_FT_FI15
Number of Residues	20
Details	TRANSMEM: Helical; Name=12 => ECO:0000305

Chain	Residue	Details
A	LEU434-GLY454

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER225

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P41438

Chain	Residue	Details
A	SER474
A	SER485

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER499
A	SER503

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:9767079

Chain	Residue	Details
A	ASN58

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