8HII
The BRIL-SLC19A1/Fab/Nb ternary complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005542 | molecular_function | folic acid binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006855 | biological_process | xenobiotic transmembrane transport |
| A | 0007565 | biological_process | female pregnancy |
| A | 0008514 | molecular_function | organic anion transmembrane transporter activity |
| A | 0008517 | molecular_function | folic acid transmembrane transporter activity |
| A | 0008518 | molecular_function | folate:monoatomic anion antiporter activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015350 | molecular_function | methotrexate transmembrane transporter activity |
| A | 0015711 | biological_process | organic anion transport |
| A | 0015884 | biological_process | folic acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051180 | biological_process | vitamin transport |
| A | 0051958 | biological_process | methotrexate transport |
| A | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| A | 0090482 | molecular_function | vitamin transmembrane transporter activity |
| A | 0098656 | biological_process | monoatomic anion transmembrane transport |
| A | 0098838 | biological_process | folate transmembrane transport |
| A | 0140360 | molecular_function | cyclic-GMP-AMP transmembrane transporter activity |
| A | 0140361 | biological_process | cyclic-GMP-AMP transmembrane import across plasma membrane |
| A | 0141111 | biological_process | positive regulation of cGAS/STING signaling pathway |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1904447 | biological_process | folate import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| H | TYR208-HIS214 | |
| L | TYR194-HIS200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP-76 | |
| A | ILE19 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | CYS30-PRO50 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 43 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | TYR51-VAL64 | |
| A | GLY113-VAL116 | |
| A | ARG179-SER183 | |
| A | ASN293-VAL304 | |
| A | HIS355-SER360 | |
| A | GLY423-LYS430 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | THR65-THR87 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 232 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | ASP88-ARG91 | |
| A | ILE140-ALA153 | |
| A | LEU203-GLN266 | |
| A | LYS328-ARG333 | |
| A | PHE385-LEU398 | |
| A | ARG456-GLN591 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | TYR92-LEU112 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | ALA117-TYR139 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | GLY154-GLY178 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | THR184-PHE202 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | LEU267-TRP292 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | TYR305-VAL327 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | TRP334-ALA354 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | SER361-THR384 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | VAL399-ARG422 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:7TX6, ECO:0007744|PDB:7TX7, ECO:0007744|PDB:7XPZ, ECO:0007744|PDB:7XQ0, ECO:0007744|PDB:7XQ1, ECO:0007744|PDB:7XQ2, ECO:0007744|PDB:8DEP, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8GOF, ECO:0007744|PDB:8HII, ECO:0007744|PDB:8HIJ, ECO:0007744|PDB:8HIK |
| Chain | Residue | Details |
| A | GLN431-LEU455 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36575193, ECO:0007744|PDB:8GOE, ECO:0007744|PDB:8HIJ |
| Chain | Residue | Details |
| A | ILE48 | |
| A | GLN377 | |
| A | THR49 | |
| A | GLU123 | |
| A | ARG133 | |
| A | VAL164 | |
| A | TYR281 | |
| A | TYR282 | |
| A | TYR286 | |
| A | ARG373 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36265513, ECO:0007744|PDB:7XQ2 |
| Chain | Residue | Details |
| A | ILE134 | |
| A | PHE400 | |
| A | SER137 | |
| A | TYR149 | |
| A | ARG157 | |
| A | SER321 | |
| A | PRO381 | |
| A | THR384 | |
| A | LYS393 | |
| A | CYS396 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER225 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P41438 |
| Chain | Residue | Details |
| A | SER474 | |
| A | SER485 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER499 | |
| A | SER503 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:9767079 |
| Chain | Residue | Details |
| A | ASN58 |
