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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8HGS

The EGF-bound EGFR ectodomain homodimer

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CnCvvGyiGErC

Chain	Residue	Details
C	CYS31-CYS42

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CnCvvGYiger....C

Chain	Residue	Details
C	CYS31-CYS42

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1240
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	LEU25-SER645
B	LEU25-SER645

site_id	SWS_FT_FI2
Number of Residues	44
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE646-MET668
B	ILE646-MET668

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:21487020

Chain	Residue	Details
A	SER229
B	SER229

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC and PKD/PRKD1 => ECO:0000269\|PubMed:10523301

Chain	Residue	Details
A	THR678
B	THR678

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; atypical; partial => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1MOX, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3QWQ

Chain	Residue	Details
A	ASN56
B	ASN56

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; atypical => ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:3NJP

Chain	Residue	Details
A	ASN73
B	ASN73

site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:8962717

Chain	Residue	Details
A	ASN128
B	ASN128

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:3NJP

Chain	Residue	Details
A	ASN175
B	ASN175

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1MOX, ECO:0007744\|PDB:3NJP

Chain	Residue	Details
A	ASN196
B	ASN196

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1MOX, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3P0Y, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRL, ECO:0007744\|PDB:4KRM, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UIP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
A	ASN352
B	ASN352

site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRL, ECO:0007744\|PDB:4KRM, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
A	ASN361
B	ASN361

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3P0Y, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP

Chain	Residue	Details
A	ASN413
B	ASN413

site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1IVO, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2U, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3P0Y, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRL, ECO:0007744\|PDB:4KRM, ECO:0007744\|PDB:4KRO, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UIP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
A	ASN444
B	ASN444

site_id	SWS_FT_FI14
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:25922362, ECO:0000269\|PubMed:8962717, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9, ECO:0007744\|PDB:3B2V, ECO:0007744\|PDB:3NJP, ECO:0007744\|PDB:3QWQ, ECO:0007744\|PDB:4KRP, ECO:0007744\|PDB:4UIP, ECO:0007744\|PDB:4UV7

Chain	Residue	Details
A	ASN528
B	ASN528

site_id	SWS_FT_FI15
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0000269\|PubMed:19159218, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9

Chain	Residue	Details
A	ASN568
B	ASN568

site_id	SWS_FT_FI16
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269\|PubMed:10731668, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12731890, ECO:0000269\|PubMed:16083266, ECO:0007744\|PDB:1NQL, ECO:0007744\|PDB:1YY9

Chain	Residue	Details
A	ASN603
B	ASN603

site_id	SWS_FT_FI17
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000305\|PubMed:12731890

Chain	Residue	Details
A	ASN623
B	ASN623

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PDB entries from 2024-06-12

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