8HF3

Cryo-EM structure of human ZDHHC9/GCP16 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000165	biological_process	MAPK cascade
A	0002178	cellular_component	palmitoyltransferase complex
A	0002826	biological_process	negative regulation of T-helper 1 type immune response
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006612	biological_process	protein targeting to membrane
A	0016020	cellular_component	membrane
A	0016409	molecular_function	palmitoyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0018230	biological_process	peptidyl-L-cysteine S-palmitoylation
A	0019062	biological_process	virion attachment to host cell
A	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
A	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
A	0036503	biological_process	ERAD pathway
A	0043849	molecular_function	Ras palmitoyltransferase activity
A	0044794	biological_process	positive regulation by host of viral process
A	0051604	biological_process	protein maturation
A	0140639	biological_process	positive regulation of pyroptotic inflammatory response
A	0140896	biological_process	cGAS/STING signaling pathway
A	0141111	biological_process	positive regulation of cGAS/STING signaling pathway
A	0141201	biological_process	pyroptotic cell death
B	0000139	cellular_component	Golgi membrane
B	0002178	cellular_component	palmitoyltransferase complex
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005794	cellular_component	Golgi apparatus
B	0005795	cellular_component	Golgi stack
B	0006612	biological_process	protein targeting to membrane
B	0006893	biological_process	Golgi to plasma membrane transport
B	0016020	cellular_component	membrane
B	0018230	biological_process	peptidyl-L-cysteine S-palmitoylation
B	0043001	biological_process	Golgi to plasma membrane protein transport
B	0050821	biological_process	protein stabilization
B	0070062	cellular_component	extracellular exosome
B	1904724	cellular_component	tertiary granule lumen

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	29
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	98
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	50
Details	Domain: {"description":"DHHC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00067","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Active site: {"description":"S-palmitoyl cysteine intermediate","evidences":[{"source":"PubMed","id":"16000296","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37802025","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"14522980","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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