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8HF3

Cryo-EM structure of human ZDHHC9/GCP16 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000165biological_processMAPK cascade
A0002178cellular_componentpalmitoyltransferase complex
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006612biological_processprotein targeting to membrane
A0016020cellular_componentmembrane
A0016409molecular_functionpalmitoyltransferase activity
A0016746molecular_functionacyltransferase activity
A0018230biological_processpeptidyl-L-cysteine S-palmitoylation
A0018345biological_processprotein palmitoylation
A0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0043849molecular_functionRas palmitoyltransferase activity
A0044794biological_processpositive regulation by host of viral process
A0140639biological_processpositive regulation of pyroptotic inflammatory response
A0141111biological_processpositive regulation of cGAS/STING signaling pathway
B0000139cellular_componentGolgi membrane
B0002178cellular_componentpalmitoyltransferase complex
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005794cellular_componentGolgi apparatus
B0005795cellular_componentGolgi stack
B0006612biological_processprotein targeting to membrane
B0006893biological_processGolgi to plasma membrane transport
B0016020cellular_componentmembrane
B0018230biological_processpeptidyl-L-cysteine S-palmitoylation
B0043001biological_processGolgi to plasma membrane protein transport
B0050821biological_processprotein stabilization
B0070062cellular_componentextracellular exosome
B1904724cellular_componenttertiary granule lumen
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:14522980
ChainResidueDetails
BCYS69
BCYS72
AVAL250-LYS364

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AGLY36-GLU56
ALEU64-LEU84
APHE184-VAL204
AVAL229-LEU249

site_idSWS_FT_FI3
Number of Residues29
DetailsTOPO_DOM: Lumenal => ECO:0000255
ChainResidueDetails
ACYS57-GLN63
ATYR205-GLU228

site_idSWS_FT_FI4
Number of Residues1
DetailsACT_SITE: S-palmitoyl cysteine intermediate => ECO:0000305|PubMed:16000296, ECO:0000305|PubMed:37802025
ChainResidueDetails
ACYS169

222415

PDB entries from 2024-07-10

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