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8HDP

Structure of A2BR bound to endogenous agonists adenosine

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001609molecular_functionG protein-coupled adenosine receptor activity
R0001973biological_processG protein-coupled adenosine receptor signaling pathway
R0002882biological_processpositive regulation of chronic inflammatory response to non-antigenic stimulus
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007190biological_processactivation of adenylate cyclase activity
R0010575biological_processpositive regulation of vascular endothelial growth factor production
R0010753biological_processpositive regulation of cGMP-mediated signaling
R0016020cellular_componentmembrane
R0019934biological_processcGMP-mediated signaling
R0031668biological_processobsolete cellular response to extracellular stimulus
R0032722biological_processpositive regulation of chemokine production
R0032755biological_processpositive regulation of interleukin-6 production
R0042311biological_processvasodilation
R0043303biological_processmast cell degranulation
R0043306biological_processpositive regulation of mast cell degranulation
R0045202cellular_componentsynapse
R0060087biological_processrelaxation of vascular associated smooth muscle
R0098685cellular_componentSchaffer collateral - CA1 synapse
R0098793cellular_componentpresynapse
R0098978cellular_componentglutamatergic synapse
R0099171biological_processpresynaptic modulation of chemical synaptic transmission
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAVAVDRYLaI
ChainResidueDetails
RSER91-ILE107

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues57
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
RMET1-ALA8
RSER68-CYS78
RASN145-PRO178
RGLN260-LYS267
AASP85
AASN144
ASER218

site_idSWS_FT_FI2
Number of Residues24
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250
ChainResidueDetails
RLEU9-GLY33

site_idSWS_FT_FI3
Number of Residues99
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
RTHR34-ASN43
RASP102-ARG121
RLYS204-SER235
RTYR292-LEU332

site_idSWS_FT_FI4
Number of Residues23
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250
ChainResidueDetails
RTYR44-ILE67

site_idSWS_FT_FI5
Number of Residues22
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250
ChainResidueDetails
RLEU79-VAL101

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250
ChainResidueDetails
RALA122-TRP144

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250
ChainResidueDetails
RMET179-ILE203

site_idSWS_FT_FI8
Number of Residues23
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250
ChainResidueDetails
RLEU236-PHE259

site_idSWS_FT_FI9
Number of Residues23
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250
ChainResidueDetails
RPRO268-ALA291

site_idSWS_FT_FI10
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P29274
ChainResidueDetails
RGLU174
RASN254
RSER279
RHIS280

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
RCYS311

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN153
RASN163

222415

PDB entries from 2024-07-10

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