Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8HCO

Substrate-engaged TOM complex from yeast

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005742	cellular_component	mitochondrial outer membrane translocase complex
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006811	biological_process	monoatomic ion transport
A	0008320	molecular_function	protein transmembrane transporter activity
A	0015031	biological_process	protein transport
A	0015288	molecular_function	porin activity
A	0030150	biological_process	protein import into mitochondrial matrix
A	0045040	biological_process	protein insertion into mitochondrial outer membrane
A	0046930	cellular_component	pore complex
A	0055085	biological_process	transmembrane transport
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005742	cellular_component	mitochondrial outer membrane translocase complex
B	0006886	biological_process	intracellular protein transport
B	0008320	molecular_function	protein transmembrane transporter activity
B	0015031	biological_process	protein transport
B	0030150	biological_process	protein import into mitochondrial matrix
B	0045040	biological_process	protein insertion into mitochondrial outer membrane
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005742	cellular_component	mitochondrial outer membrane translocase complex
C	0006626	biological_process	protein targeting to mitochondrion
C	0008320	molecular_function	protein transmembrane transporter activity
C	0015031	biological_process	protein transport
C	0045040	biological_process	protein insertion into mitochondrial outer membrane
C	0070096	biological_process	mitochondrial outer membrane translocase complex assembly
C	0071806	biological_process	protein transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005742	cellular_component	mitochondrial outer membrane translocase complex
D	0008320	molecular_function	protein transmembrane transporter activity
D	0015031	biological_process	protein transport
D	0030150	biological_process	protein import into mitochondrial matrix
D	0045040	biological_process	protein insertion into mitochondrial outer membrane
D	0070096	biological_process	mitochondrial outer membrane translocase complex assembly
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005742	cellular_component	mitochondrial outer membrane translocase complex
E	0008320	molecular_function	protein transmembrane transporter activity
E	0015031	biological_process	protein transport
E	0030150	biological_process	protein import into mitochondrial matrix
E	0045040	biological_process	protein insertion into mitochondrial outer membrane
G	0003674	molecular_function	molecular_function
G	0004146	molecular_function	dihydrofolate reductase activity
G	0005515	molecular_function	protein binding
G	0005542	molecular_function	folic acid binding
G	0005575	cellular_component	cellular_component
G	0005829	cellular_component	cytosol
G	0006091	biological_process	generation of precursor metabolites and energy
G	0006730	biological_process	one-carbon metabolic process
G	0008218	biological_process	bioluminescence
G	0009257	biological_process	10-formyltetrahydrofolate biosynthetic process
G	0009410	biological_process	response to xenobiotic stimulus
G	0016491	molecular_function	oxidoreductase activity
G	0031427	biological_process	response to methotrexate
G	0046452	biological_process	dihydrofolate metabolic process
G	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0046655	biological_process	folic acid metabolic process
G	0046656	biological_process	folic acid biosynthetic process
G	0046677	biological_process	response to antibiotic
G	0050661	molecular_function	NADP binding
G	0051870	molecular_function	methotrexate binding
G	0051871	molecular_function	dihydrofolic acid binding
G	0070401	molecular_function	NADP+ binding
G	0070402	molecular_function	NADPH binding
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0005742	cellular_component	mitochondrial outer membrane translocase complex
I	0005758	cellular_component	mitochondrial intermembrane space
I	0005829	cellular_component	cytosol
I	0006811	biological_process	monoatomic ion transport
I	0008320	molecular_function	protein transmembrane transporter activity
I	0015031	biological_process	protein transport
I	0015288	molecular_function	porin activity
I	0030150	biological_process	protein import into mitochondrial matrix
I	0045040	biological_process	protein insertion into mitochondrial outer membrane
I	0046930	cellular_component	pore complex
I	0055085	biological_process	transmembrane transport
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005741	cellular_component	mitochondrial outer membrane
J	0005742	cellular_component	mitochondrial outer membrane translocase complex
J	0006886	biological_process	intracellular protein transport
J	0008320	molecular_function	protein transmembrane transporter activity
J	0015031	biological_process	protein transport
J	0030150	biological_process	protein import into mitochondrial matrix
J	0045040	biological_process	protein insertion into mitochondrial outer membrane
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005741	cellular_component	mitochondrial outer membrane
K	0005742	cellular_component	mitochondrial outer membrane translocase complex
K	0006626	biological_process	protein targeting to mitochondrion
K	0008320	molecular_function	protein transmembrane transporter activity
K	0015031	biological_process	protein transport
K	0045040	biological_process	protein insertion into mitochondrial outer membrane
K	0070096	biological_process	mitochondrial outer membrane translocase complex assembly
K	0071806	biological_process	protein transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005741	cellular_component	mitochondrial outer membrane
L	0005742	cellular_component	mitochondrial outer membrane translocase complex
L	0008320	molecular_function	protein transmembrane transporter activity
L	0015031	biological_process	protein transport
L	0030150	biological_process	protein import into mitochondrial matrix
L	0045040	biological_process	protein insertion into mitochondrial outer membrane
L	0070096	biological_process	mitochondrial outer membrane translocase complex assembly
M	0005739	cellular_component	mitochondrion
M	0005741	cellular_component	mitochondrial outer membrane
M	0005742	cellular_component	mitochondrial outer membrane translocase complex
M	0008320	molecular_function	protein transmembrane transporter activity
M	0015031	biological_process	protein transport
M	0030150	biological_process	protein import into mitochondrial matrix
M	0045040	biological_process	protein insertion into mitochondrial outer membrane

Functional Information from PROSITE/UniProt

site_id	PS00075
Number of Residues	23
Details	DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT

Chain	Residue	Details
G	VAL88-THR110

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:11914072, ECO:0000269\|PubMed:2329585, ECO:0007744\|PDB:1FCB, ECO:0007744\|PDB:1KBI

Chain	Residue	Details
G	GLU92
M	SER2-LYS19

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000305\|PubMed:9012674

Chain	Residue	Details
G	ILE80
G	ASP102
G	ARG127
G	ARG132
G	THR188

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:19374017

Chain	Residue	Details
G	ALA82
G	VAL88
G	HIS120
G	SER138
G	LYS151
G	GLY170

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269\|PubMed:8448132

Chain	Residue	Details
G	VAL346
L	MET1
J	SER44
J	SER46

site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269\|PubMed:8448132

Chain	Residue	Details
G	GYS344
G	GLN347

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 102

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)