8HCN

CryoEM Structure of Klebsiella pneumoniae UreD/urease complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0009039	molecular_function	urease activity
A	0016151	molecular_function	nickel cation binding
A	0016787	molecular_function	hydrolase activity
A	0019627	biological_process	urea metabolic process
A	0043419	biological_process	urea catabolic process
B	0005737	cellular_component	cytoplasm
B	0009039	molecular_function	urease activity
B	0016787	molecular_function	hydrolase activity
B	0035550	cellular_component	urease complex
B	0043419	biological_process	urea catabolic process
C	0005737	cellular_component	cytoplasm
C	0009039	molecular_function	urease activity
C	0016151	molecular_function	nickel cation binding
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0019627	biological_process	urea metabolic process
C	0043419	biological_process	urea catabolic process
C	0046872	molecular_function	metal ion binding
D	0005737	cellular_component	cytoplasm
D	0016151	molecular_function	nickel cation binding
E	0005737	cellular_component	cytoplasm
E	0009039	molecular_function	urease activity
E	0016151	molecular_function	nickel cation binding
E	0016787	molecular_function	hydrolase activity
E	0019627	biological_process	urea metabolic process
E	0043419	biological_process	urea catabolic process
F	0005737	cellular_component	cytoplasm
F	0009039	molecular_function	urease activity
F	0016787	molecular_function	hydrolase activity
F	0035550	cellular_component	urease complex
F	0043419	biological_process	urea catabolic process
G	0005737	cellular_component	cytoplasm
G	0009039	molecular_function	urease activity
G	0016151	molecular_function	nickel cation binding
G	0016787	molecular_function	hydrolase activity
G	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
G	0019627	biological_process	urea metabolic process
G	0043419	biological_process	urea catabolic process
G	0046872	molecular_function	metal ion binding
H	0005737	cellular_component	cytoplasm
H	0016151	molecular_function	nickel cation binding
I	0005737	cellular_component	cytoplasm
I	0009039	molecular_function	urease activity
I	0016151	molecular_function	nickel cation binding
I	0016787	molecular_function	hydrolase activity
I	0019627	biological_process	urea metabolic process
I	0043419	biological_process	urea catabolic process
J	0005737	cellular_component	cytoplasm
J	0009039	molecular_function	urease activity
J	0016787	molecular_function	hydrolase activity
J	0035550	cellular_component	urease complex
J	0043419	biological_process	urea catabolic process
K	0005737	cellular_component	cytoplasm
K	0009039	molecular_function	urease activity
K	0016151	molecular_function	nickel cation binding
K	0016787	molecular_function	hydrolase activity
K	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
K	0019627	biological_process	urea metabolic process
K	0043419	biological_process	urea catabolic process
K	0046872	molecular_function	metal ion binding
L	0005737	cellular_component	cytoplasm
L	0016151	molecular_function	nickel cation binding

Functional Information from PROSITE/UniProt

site_id	PS00145
Number of Residues	17
Details	UREASE_2 Urease active site. MVCHHLdpdIaeDVaFA

Chain	Residue	Details
C	MET317-ALA333

---

site_id	PS01120
Number of Residues	14
Details	UREASE_1 Urease nickel ligands signature. TAGGIDtHIHwicP

Chain	Residue	Details
C	THR127-PRO140

---