8HBE

Structure of human soluble guanylate cyclase in the inactive state at 3.1 angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004383	molecular_function	guanylate cyclase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006182	biological_process	cGMP biosynthetic process
A	0007263	biological_process	nitric oxide mediated signal transduction
A	0008015	biological_process	blood circulation
A	0008074	cellular_component	guanylate cyclase complex, soluble
A	0008217	biological_process	regulation of blood pressure
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0010750	biological_process	positive regulation of nitric oxide mediated signal transduction
A	0016829	molecular_function	lyase activity
A	0016849	molecular_function	phosphorus-oxygen lyase activity
A	0019934	biological_process	obsolete cGMP-mediated signaling
A	0020037	molecular_function	heme binding
A	0035556	biological_process	intracellular signal transduction
A	0038023	molecular_function	signaling receptor activity
A	0038060	biological_process	nitric oxide-cGMP-mediated signaling
A	0060087	biological_process	relaxation of vascular associated smooth muscle
A	0070482	biological_process	response to oxygen levels
A	0098925	biological_process	retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
A	0098978	cellular_component	glutamatergic synapse
A	0098982	cellular_component	GABA-ergic synapse
B	0000166	molecular_function	nucleotide binding
B	0004016	molecular_function	adenylate cyclase activity
B	0004383	molecular_function	guanylate cyclase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006182	biological_process	cGMP biosynthetic process
B	0007263	biological_process	nitric oxide mediated signal transduction
B	0008015	biological_process	blood circulation
B	0008074	cellular_component	guanylate cyclase complex, soluble
B	0009190	biological_process	cyclic nucleotide biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016849	molecular_function	phosphorus-oxygen lyase activity
B	0019934	biological_process	obsolete cGMP-mediated signaling
B	0020037	molecular_function	heme binding
B	0032991	cellular_component	protein-containing complex
B	0035556	biological_process	intracellular signal transduction
B	0038023	molecular_function	signaling receptor activity
B	0038060	biological_process	nitric oxide-cGMP-mediated signaling
B	0044877	molecular_function	protein-containing complex binding
B	0046872	molecular_function	metal ion binding
B	0047805	molecular_function	cytidylate cyclase activity
B	0051879	molecular_function	Hsp90 protein binding
B	0070026	molecular_function	nitric oxide binding
B	0070482	biological_process	response to oxygen levels
B	0071732	biological_process	cellular response to nitric oxide
B	0098831	cellular_component	presynaptic active zone cytoplasmic component
B	0098978	cellular_component	glutamatergic synapse

Functional Information from PROSITE/UniProt

site_id	PS00452
Number of Residues	24
Details	GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVI.GqrmprYcLFGNTVNltsrtE

Chain	Residue	Details
B	GLY531-GLU554
A	GLY585-GLU608

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	260
Details	Domain: {"description":"Guanylate cyclase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"UniProtKB","id":"P16068","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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