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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8HB9

Crystal Structure of Human IDH1 R132H Mutant in Complex with NADPH and Compound IHMT-IDH1-053

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AAA0000287molecular_functionmagnesium ion binding
AAA0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
AAA0005515molecular_functionprotein binding
AAA0005576cellular_componentextracellular region
AAA0005737cellular_componentcytoplasm
AAA0005739cellular_componentmitochondrion
AAA0005777cellular_componentperoxisome
AAA0005782cellular_componentperoxisomal matrix
AAA0005829cellular_componentcytosol
AAA0006097biological_processglyoxylate cycle
AAA0006099biological_processtricarboxylic acid cycle
AAA0006102biological_processisocitrate metabolic process
AAA0006103biological_process2-oxoglutarate metabolic process
AAA0006739biological_processNADP+ metabolic process
AAA0006740biological_processNADPH regeneration
AAA0006749biological_processglutathione metabolic process
AAA0006979biological_processresponse to oxidative stress
AAA0008585biological_processfemale gonad development
AAA0016491molecular_functionoxidoreductase activity
AAA0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
AAA0034774cellular_componentsecretory granule lumen
AAA0042802molecular_functionidentical protein binding
AAA0042803molecular_functionprotein homodimerization activity
AAA0045296molecular_functioncadherin binding
AAA0046872molecular_functionmetal ion binding
AAA0048545biological_processresponse to steroid hormone
AAA0050661molecular_functionNADP binding
AAA0051287molecular_functionNAD binding
AAA0060696biological_processregulation of phospholipid catabolic process
AAA0070062cellular_componentextracellular exosome
AAA0071071biological_processregulation of phospholipid biosynthetic process
AAA1904724cellular_componenttertiary granule lumen
AAA1904813cellular_componentficolin-1-rich granule lumen
BBB0000287molecular_functionmagnesium ion binding
BBB0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
BBB0005515molecular_functionprotein binding
BBB0005576cellular_componentextracellular region
BBB0005737cellular_componentcytoplasm
BBB0005739cellular_componentmitochondrion
BBB0005777cellular_componentperoxisome
BBB0005782cellular_componentperoxisomal matrix
BBB0005829cellular_componentcytosol
BBB0006097biological_processglyoxylate cycle
BBB0006099biological_processtricarboxylic acid cycle
BBB0006102biological_processisocitrate metabolic process
BBB0006103biological_process2-oxoglutarate metabolic process
BBB0006739biological_processNADP+ metabolic process
BBB0006740biological_processNADPH regeneration
BBB0006749biological_processglutathione metabolic process
BBB0006979biological_processresponse to oxidative stress
BBB0008585biological_processfemale gonad development
BBB0016491molecular_functionoxidoreductase activity
BBB0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
BBB0034774cellular_componentsecretory granule lumen
BBB0042802molecular_functionidentical protein binding
BBB0042803molecular_functionprotein homodimerization activity
BBB0045296molecular_functioncadherin binding
BBB0046872molecular_functionmetal ion binding
BBB0048545biological_processresponse to steroid hormone
BBB0050661molecular_functionNADP binding
BBB0051287molecular_functionNAD binding
BBB0060696biological_processregulation of phospholipid catabolic process
BBB0070062cellular_componentextracellular exosome
BBB0071071biological_processregulation of phospholipid biosynthetic process
BBB1904724cellular_componenttertiary granule lumen
BBB1904813cellular_componentficolin-1-rich granule lumen
CCC0000287molecular_functionmagnesium ion binding
CCC0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
CCC0005515molecular_functionprotein binding
CCC0005576cellular_componentextracellular region
CCC0005737cellular_componentcytoplasm
CCC0005739cellular_componentmitochondrion
CCC0005777cellular_componentperoxisome
CCC0005782cellular_componentperoxisomal matrix
CCC0005829cellular_componentcytosol
CCC0006097biological_processglyoxylate cycle
CCC0006099biological_processtricarboxylic acid cycle
CCC0006102biological_processisocitrate metabolic process
CCC0006103biological_process2-oxoglutarate metabolic process
CCC0006739biological_processNADP+ metabolic process
CCC0006740biological_processNADPH regeneration
CCC0006749biological_processglutathione metabolic process
CCC0006979biological_processresponse to oxidative stress
CCC0008585biological_processfemale gonad development
CCC0016491molecular_functionoxidoreductase activity
CCC0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
CCC0034774cellular_componentsecretory granule lumen
CCC0042802molecular_functionidentical protein binding
CCC0042803molecular_functionprotein homodimerization activity
CCC0045296molecular_functioncadherin binding
CCC0046872molecular_functionmetal ion binding
CCC0048545biological_processresponse to steroid hormone
CCC0050661molecular_functionNADP binding
CCC0051287molecular_functionNAD binding
CCC0060696biological_processregulation of phospholipid catabolic process
CCC0070062cellular_componentextracellular exosome
CCC0071071biological_processregulation of phospholipid biosynthetic process
CCC1904724cellular_componenttertiary granule lumen
CCC1904813cellular_componentficolin-1-rich granule lumen
DDD0000287molecular_functionmagnesium ion binding
DDD0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
DDD0005515molecular_functionprotein binding
DDD0005576cellular_componentextracellular region
DDD0005737cellular_componentcytoplasm
DDD0005739cellular_componentmitochondrion
DDD0005777cellular_componentperoxisome
DDD0005782cellular_componentperoxisomal matrix
DDD0005829cellular_componentcytosol
DDD0006097biological_processglyoxylate cycle
DDD0006099biological_processtricarboxylic acid cycle
DDD0006102biological_processisocitrate metabolic process
DDD0006103biological_process2-oxoglutarate metabolic process
DDD0006739biological_processNADP+ metabolic process
DDD0006740biological_processNADPH regeneration
DDD0006749biological_processglutathione metabolic process
DDD0006979biological_processresponse to oxidative stress
DDD0008585biological_processfemale gonad development
DDD0016491molecular_functionoxidoreductase activity
DDD0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
DDD0034774cellular_componentsecretory granule lumen
DDD0042802molecular_functionidentical protein binding
DDD0042803molecular_functionprotein homodimerization activity
DDD0045296molecular_functioncadherin binding
DDD0046872molecular_functionmetal ion binding
DDD0048545biological_processresponse to steroid hormone
DDD0050661molecular_functionNADP binding
DDD0051287molecular_functionNAD binding
DDD0060696biological_processregulation of phospholipid catabolic process
DDD0070062cellular_componentextracellular exosome
DDD0071071biological_processregulation of phospholipid biosynthetic process
DDD1904724cellular_componenttertiary granule lumen
DDD1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PROSITE/UniProt
site_idPS00470
Number of Residues20
DetailsIDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NYDGDVqSDsvAqgy.GSLGM
ChainResidueDetails
AAAASN271-MET290
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15173171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19935646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3INM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I3K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I3L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XS3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TQH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues36
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"15173171","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T0L","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15173171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19935646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3INM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I3K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I3L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XS3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TQH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15173171","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T0L","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15173171","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19935646","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1T0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3INM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15173171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19935646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3INM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"15173171","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19935646","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1T0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3INM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsSite: {"description":"Critical for catalysis"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues16
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O88844","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O88844","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O88844","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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