Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8H9P

Human ATP synthase F1 domain, state 3b

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
A	0001937	biological_process	negative regulation of endothelial cell proliferation
A	0002020	molecular_function	protease binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
A	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
A	0005759	cellular_component	mitochondrial matrix
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006754	biological_process	ATP biosynthetic process
A	0008180	cellular_component	COP9 signalosome
A	0009986	cellular_component	cell surface
A	0014850	biological_process	response to muscle activity
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0016469	cellular_component	proton-transporting two-sector ATPase complex
A	0016887	molecular_function	ATP hydrolysis activity
A	0031090	cellular_component	organelle membrane
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0042288	molecular_function	MHC class I protein binding
A	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
A	0043531	molecular_function	ADP binding
A	0043532	molecular_function	angiostatin binding
A	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
A	0045121	cellular_component	membrane raft
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
A	0045471	biological_process	response to ethanol
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0070062	cellular_component	extracellular exosome
A	0071549	biological_process	cellular response to dexamethasone stimulus
A	0071732	biological_process	cellular response to nitric oxide
A	1902600	biological_process	proton transmembrane transport
B	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
B	0001937	biological_process	negative regulation of endothelial cell proliferation
B	0002020	molecular_function	protease binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
B	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
B	0005759	cellular_component	mitochondrial matrix
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006754	biological_process	ATP biosynthetic process
B	0008180	cellular_component	COP9 signalosome
B	0009986	cellular_component	cell surface
B	0014850	biological_process	response to muscle activity
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0016469	cellular_component	proton-transporting two-sector ATPase complex
B	0016887	molecular_function	ATP hydrolysis activity
B	0031090	cellular_component	organelle membrane
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0042288	molecular_function	MHC class I protein binding
B	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
B	0043531	molecular_function	ADP binding
B	0043532	molecular_function	angiostatin binding
B	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
B	0045121	cellular_component	membrane raft
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
B	0045471	biological_process	response to ethanol
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0070062	cellular_component	extracellular exosome
B	0071549	biological_process	cellular response to dexamethasone stimulus
B	0071732	biological_process	cellular response to nitric oxide
B	1902600	biological_process	proton transmembrane transport
C	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
C	0001937	biological_process	negative regulation of endothelial cell proliferation
C	0002020	molecular_function	protease binding
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
C	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
C	0005759	cellular_component	mitochondrial matrix
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006754	biological_process	ATP biosynthetic process
C	0008180	cellular_component	COP9 signalosome
C	0009986	cellular_component	cell surface
C	0014850	biological_process	response to muscle activity
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0016469	cellular_component	proton-transporting two-sector ATPase complex
C	0016887	molecular_function	ATP hydrolysis activity
C	0031090	cellular_component	organelle membrane
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0042288	molecular_function	MHC class I protein binding
C	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
C	0043531	molecular_function	ADP binding
C	0043532	molecular_function	angiostatin binding
C	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
C	0045121	cellular_component	membrane raft
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
C	0045471	biological_process	response to ethanol
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0070062	cellular_component	extracellular exosome
C	0071549	biological_process	cellular response to dexamethasone stimulus
C	0071732	biological_process	cellular response to nitric oxide
C	1902600	biological_process	proton transmembrane transport
D	0001525	biological_process	angiogenesis
D	0001649	biological_process	osteoblast differentiation
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
D	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
D	0005759	cellular_component	mitochondrial matrix
D	0005886	cellular_component	plasma membrane
D	0006091	biological_process	generation of precursor metabolites and energy
D	0006629	biological_process	lipid metabolic process
D	0006754	biological_process	ATP biosynthetic process
D	0006933	biological_process	negative regulation of cell adhesion involved in substrate-bound cell migration
D	0009986	cellular_component	cell surface
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016469	cellular_component	proton-transporting two-sector ATPase complex
D	0016887	molecular_function	ATP hydrolysis activity
D	0031090	cellular_component	organelle membrane
D	0031966	cellular_component	mitochondrial membrane
D	0042288	molecular_function	MHC class I protein binding
D	0042645	cellular_component	mitochondrial nucleoid
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0043532	molecular_function	angiostatin binding
D	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0051453	biological_process	regulation of intracellular pH
D	0070062	cellular_component	extracellular exosome
D	0098761	biological_process	cellular response to interleukin-7
D	1902600	biological_process	proton transmembrane transport
E	0001525	biological_process	angiogenesis
E	0001649	biological_process	osteoblast differentiation
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
E	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
E	0005759	cellular_component	mitochondrial matrix
E	0005886	cellular_component	plasma membrane
E	0006091	biological_process	generation of precursor metabolites and energy
E	0006629	biological_process	lipid metabolic process
E	0006754	biological_process	ATP biosynthetic process
E	0006933	biological_process	negative regulation of cell adhesion involved in substrate-bound cell migration
E	0009986	cellular_component	cell surface
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016469	cellular_component	proton-transporting two-sector ATPase complex
E	0016887	molecular_function	ATP hydrolysis activity
E	0031090	cellular_component	organelle membrane
E	0031966	cellular_component	mitochondrial membrane
E	0042288	molecular_function	MHC class I protein binding
E	0042645	cellular_component	mitochondrial nucleoid
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0043532	molecular_function	angiostatin binding
E	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	0051453	biological_process	regulation of intracellular pH
E	0070062	cellular_component	extracellular exosome
E	0098761	biological_process	cellular response to interleukin-7
E	1902600	biological_process	proton transmembrane transport
F	0001525	biological_process	angiogenesis
F	0001649	biological_process	osteoblast differentiation
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
F	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
F	0005759	cellular_component	mitochondrial matrix
F	0005886	cellular_component	plasma membrane
F	0006091	biological_process	generation of precursor metabolites and energy
F	0006629	biological_process	lipid metabolic process
F	0006754	biological_process	ATP biosynthetic process
F	0006933	biological_process	negative regulation of cell adhesion involved in substrate-bound cell migration
F	0009986	cellular_component	cell surface
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0016469	cellular_component	proton-transporting two-sector ATPase complex
F	0016887	molecular_function	ATP hydrolysis activity
F	0031090	cellular_component	organelle membrane
F	0031966	cellular_component	mitochondrial membrane
F	0042288	molecular_function	MHC class I protein binding
F	0042645	cellular_component	mitochondrial nucleoid
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0043532	molecular_function	angiostatin binding
F	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0051453	biological_process	regulation of intracellular pH
F	0070062	cellular_component	extracellular exosome
F	0098761	biological_process	cellular response to interleukin-7
F	1902600	biological_process	proton transmembrane transport
G	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
G	0005759	cellular_component	mitochondrial matrix
G	0006119	biological_process	oxidative phosphorylation
G	0006754	biological_process	ATP biosynthetic process
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
G	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016020	cellular_component	membrane
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism

Functional Information from PROSITE/UniProt

site_id	PS00389
Number of Residues	20
Details	ATPASE_DELTA ATP synthase delta (OSCP) subunit signature. LkLeakTDpSIlGGMIVRiG

Chain	Residue	Details
O	LEU148-GLY167

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITkEliEiisGAaA

Chain	Residue	Details
G	ILE258-ALA271

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSTS

Chain	Residue	Details
E	PRO349-SER358
A	PRO363-SER372

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9DB20

Chain	Residue	Details
O	LYS31
O	LYS37
O	LYS47
O	LYS50
O	LYS153
D	ARG192

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q9DB20

Chain	Residue	Details
O	LYS67
O	LYS176
E	LYS114
E	LYS212
E	LYS217
E	LYS475
F	LYS77
F	LYS86
F	LYS114
F	LYS212
F	LYS217
F	LYS475
D	LYS77
D	LYS86
D	LYS114
D	LYS212
D	LYS217
D	LYS475

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9DB20

Chain	Residue	Details
O	LYS135
O	LYS139
F	LYS151
F	LYS379
D	LYS151
D	LYS379
C	SER10
C	SER22
C	SER141

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
O	LYS149
O	LYS169
D	THR265

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
G	SER121
F	SER368
D	SER368

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P10719

Chain	Residue	Details
E	SER386
F	SER386
D	SER386
A	LYS197
A	LYS498
B	LYS80
B	LYS83
B	LYS89
B	LYS197
B	LYS498
C	LYS80
C	LYS83
C	LYS89
C	LYS197
C	LYS498

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P56480

Chain	Residue	Details
E	LYS433
E	LYS438
F	LYS433
F	LYS438
D	LYS433
D	LYS438

site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
E	SER482
F	SER482
D	SER482
A	LYS196
A	LYS218
A	LYS262
A	LYS384
A	LYS455
A	LYS463
A	LYS488
A	LYS496
B	LYS118
B	LYS124
B	LYS187
B	LYS196
B	LYS218
B	LYS262
B	LYS384
B	LYS455
B	LYS463
B	LYS488
B	LYS496
C	LYS118
C	LYS124
C	LYS187
C	LYS196
C	LYS218
C	LYS262
C	LYS384
C	LYS455
C	LYS463
C	LYS488
C	LYS496

site_id	SWS_FT_FI9
Number of Residues	3
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
E	SER59
F	SER59
D	SER59

site_id	SWS_FT_FI10
Number of Residues	3
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:Q03265

Chain	Residue	Details
A	ARG161
B	ARG161
C	ARG161

site_id	SWS_FT_FI11
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS391
B	LYS391
C	LYS391

site_id	SWS_FT_FI12
Number of Residues	3
Details	CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250

Chain	Residue	Details
A	SER33
B	SER33
C	SER33

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)