8H9I

Human ATP synthase F1 domain, state2

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001937	biological_process	negative regulation of endothelial cell proliferation
A	0002020	molecular_function	protease binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005759	cellular_component	mitochondrial matrix
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0009986	cellular_component	cell surface
A	0014850	biological_process	response to muscle activity
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0016469	cellular_component	proton-transporting two-sector ATPase complex
A	0016887	molecular_function	ATP hydrolysis activity
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0042288	molecular_function	MHC class I protein binding
A	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
A	0043531	molecular_function	ADP binding
A	0043532	molecular_function	angiostatin binding
A	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
A	0045121	cellular_component	membrane raft
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0045471	biological_process	response to ethanol
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0070062	cellular_component	extracellular exosome
A	0071549	biological_process	cellular response to dexamethasone stimulus
A	0071732	biological_process	cellular response to nitric oxide
A	0097229	cellular_component	sperm end piece
A	1902495	cellular_component	transmembrane transporter complex
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0001937	biological_process	negative regulation of endothelial cell proliferation
B	0002020	molecular_function	protease binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005759	cellular_component	mitochondrial matrix
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0009986	cellular_component	cell surface
B	0014850	biological_process	response to muscle activity
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0016469	cellular_component	proton-transporting two-sector ATPase complex
B	0016887	molecular_function	ATP hydrolysis activity
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0042288	molecular_function	MHC class I protein binding
B	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
B	0043531	molecular_function	ADP binding
B	0043532	molecular_function	angiostatin binding
B	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
B	0045121	cellular_component	membrane raft
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0045471	biological_process	response to ethanol
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0070062	cellular_component	extracellular exosome
B	0071549	biological_process	cellular response to dexamethasone stimulus
B	0071732	biological_process	cellular response to nitric oxide
B	0097229	cellular_component	sperm end piece
B	1902495	cellular_component	transmembrane transporter complex
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0001937	biological_process	negative regulation of endothelial cell proliferation
C	0002020	molecular_function	protease binding
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005759	cellular_component	mitochondrial matrix
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0009986	cellular_component	cell surface
C	0014850	biological_process	response to muscle activity
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0016469	cellular_component	proton-transporting two-sector ATPase complex
C	0016887	molecular_function	ATP hydrolysis activity
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0042288	molecular_function	MHC class I protein binding
C	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
C	0043531	molecular_function	ADP binding
C	0043532	molecular_function	angiostatin binding
C	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
C	0045121	cellular_component	membrane raft
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0045471	biological_process	response to ethanol
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0070062	cellular_component	extracellular exosome
C	0071549	biological_process	cellular response to dexamethasone stimulus
C	0071732	biological_process	cellular response to nitric oxide
C	0097229	cellular_component	sperm end piece
C	1902495	cellular_component	transmembrane transporter complex
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0001525	biological_process	angiogenesis
D	0001649	biological_process	osteoblast differentiation
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005759	cellular_component	mitochondrial matrix
D	0005886	cellular_component	plasma membrane
D	0006091	biological_process	generation of precursor metabolites and energy
D	0006629	biological_process	lipid metabolic process
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0006933	biological_process	negative regulation of cell adhesion involved in substrate-bound cell migration
D	0009986	cellular_component	cell surface
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016469	cellular_component	proton-transporting two-sector ATPase complex
D	0031966	cellular_component	mitochondrial membrane
D	0042288	molecular_function	MHC class I protein binding
D	0042645	cellular_component	mitochondrial nucleoid
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0043532	molecular_function	angiostatin binding
D	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0046034	biological_process	ATP metabolic process
D	0046872	molecular_function	metal ion binding
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0051453	biological_process	regulation of intracellular pH
D	0070062	cellular_component	extracellular exosome
D	0098761	biological_process	cellular response to interleukin-7
D	1902495	cellular_component	transmembrane transporter complex
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0001525	biological_process	angiogenesis
E	0001649	biological_process	osteoblast differentiation
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005759	cellular_component	mitochondrial matrix
E	0005886	cellular_component	plasma membrane
E	0006091	biological_process	generation of precursor metabolites and energy
E	0006629	biological_process	lipid metabolic process
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0006933	biological_process	negative regulation of cell adhesion involved in substrate-bound cell migration
E	0009986	cellular_component	cell surface
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016469	cellular_component	proton-transporting two-sector ATPase complex
E	0031966	cellular_component	mitochondrial membrane
E	0042288	molecular_function	MHC class I protein binding
E	0042645	cellular_component	mitochondrial nucleoid
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0043532	molecular_function	angiostatin binding
E	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0046034	biological_process	ATP metabolic process
E	0046872	molecular_function	metal ion binding
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	0051453	biological_process	regulation of intracellular pH
E	0070062	cellular_component	extracellular exosome
E	0098761	biological_process	cellular response to interleukin-7
E	1902495	cellular_component	transmembrane transporter complex
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0001525	biological_process	angiogenesis
F	0001649	biological_process	osteoblast differentiation
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005759	cellular_component	mitochondrial matrix
F	0005886	cellular_component	plasma membrane
F	0006091	biological_process	generation of precursor metabolites and energy
F	0006629	biological_process	lipid metabolic process
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0006933	biological_process	negative regulation of cell adhesion involved in substrate-bound cell migration
F	0009986	cellular_component	cell surface
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0016469	cellular_component	proton-transporting two-sector ATPase complex
F	0031966	cellular_component	mitochondrial membrane
F	0042288	molecular_function	MHC class I protein binding
F	0042645	cellular_component	mitochondrial nucleoid
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0043532	molecular_function	angiostatin binding
F	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0046034	biological_process	ATP metabolic process
F	0046872	molecular_function	metal ion binding
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0051453	biological_process	regulation of intracellular pH
F	0070062	cellular_component	extracellular exosome
F	0098761	biological_process	cellular response to interleukin-7
F	1902495	cellular_component	transmembrane transporter complex
F	1902600	biological_process	proton transmembrane transport
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005759	cellular_component	mitochondrial matrix
G	0006119	biological_process	oxidative phosphorylation
G	0006754	biological_process	ATP biosynthetic process
G	0006811	biological_process	monoatomic ion transport
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016020	cellular_component	membrane
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSTS

Chain	Residue	Details
E	PRO349-SER358
C	PRO363-SER372

---

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITkEliEiisGAaA

Chain	Residue	Details
G	ILE258-ALA271

---

site_id	PS00389
Number of Residues	20
Details	ATPASE_DELTA ATP synthase delta (OSCP) subunit signature. LkLeakTDpSIlGGMIVRiG

Chain	Residue	Details
O	LEU148-GLY167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37244256","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8H9V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8KI3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Required for activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q03265","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	15
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q03265","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P15999","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	33
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q03265","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q03265","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00829","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	18
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P56480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P56480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P10719","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P56480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	3
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91VR2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q91VR2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	5
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DB20","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DB20","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9DB20","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---