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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8H3Q

Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000151cellular_componentubiquitin ligase complex
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0010265biological_processSCF complex assembly
A0016020cellular_componentmembrane
A0016567biological_processprotein ubiquitination
A0017025molecular_functionTBP-class protein binding
A0030154biological_processcell differentiation
A0031461cellular_componentcullin-RING ubiquitin ligase complex
A0034774cellular_componentsecretory granule lumen
A0043086biological_processnegative regulation of catalytic activity
A0045893biological_processpositive regulation of DNA-templated transcription
A0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
C0000082biological_processG1/S transition of mitotic cell cycle
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000209biological_processprotein polyubiquitination
C0000278biological_processmitotic cell cycle
C0000902biological_processcell morphogenesis
C0000922cellular_componentspindle pole
C0001701biological_processin utero embryonic development
C0001822biological_processkidney development
C0001831biological_processtrophectodermal cellular morphogenesis
C0004842molecular_functionubiquitin-protein transferase activity
C0005112molecular_functionNotch binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005827cellular_componentpolar microtubule
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006357biological_processregulation of transcription by RNA polymerase II
C0006366biological_processtranscription by RNA polymerase II
C0006368biological_processtranscription elongation by RNA polymerase II
C0006511biological_processubiquitin-dependent protein catabolic process
C0006513biological_processprotein monoubiquitination
C0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
C0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
C0006915biological_processapoptotic process
C0006950biological_processresponse to stress
C0006954biological_processinflammatory response
C0006979biological_processresponse to oxidative stress
C0007080biological_processmitotic metaphase chromosome alignment
C0007165biological_processsignal transduction
C0007229biological_processintegrin-mediated signaling pathway
C0007369biological_processgastrulation
C0008284biological_processpositive regulation of cell population proliferation
C0010467biological_processgene expression
C0010468biological_processregulation of gene expression
C0010558biological_processnegative regulation of macromolecule biosynthetic process
C0016020cellular_componentmembrane
C0016055biological_processWnt signaling pathway
C0016192biological_processvesicle-mediated transport
C0016477biological_processcell migration
C0016567biological_processprotein ubiquitination
C0017145biological_processstem cell division
C0030030biological_processcell projection organization
C0030163biological_processprotein catabolic process
C0030332molecular_functioncyclin binding
C0031145biological_processanaphase-promoting complex-dependent catabolic process
C0031208molecular_functionPOZ domain binding
C0031398biological_processpositive regulation of protein ubiquitination
C0031461cellular_componentcullin-RING ubiquitin ligase complex
C0031463cellular_componentCul3-RING ubiquitin ligase complex
C0031514cellular_componentmotile cilium
C0031625molecular_functionubiquitin protein ligase binding
C0031648biological_processprotein destabilization
C0031669biological_processcellular response to nutrient levels
C0032467biological_processpositive regulation of cytokinesis
C0032480biological_processnegative regulation of type I interferon production
C0032481biological_processpositive regulation of type I interferon production
C0032869biological_processcellular response to insulin stimulus
C0034198biological_processcellular response to amino acid starvation
C0034599biological_processcellular response to oxidative stress
C0035024biological_processnegative regulation of Rho protein signal transduction
C0036126cellular_componentsperm flagellum
C0040016biological_processembryonic cleavage
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043149biological_processstress fiber assembly
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0044346biological_processfibroblast apoptotic process
C0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
C0048208biological_processCOPII vesicle coating
C0051301biological_processcell division
C0051865biological_processprotein autoubiquitination
C0060337biological_processtype I interferon-mediated signaling pathway
C0061630molecular_functionubiquitin protein ligase activity
C0070062cellular_componentextracellular exosome
C0070294biological_processrenal sodium ion absorption
C0070936biological_processprotein K48-linked ubiquitination
C0071230biological_processcellular response to amino acid stimulus
C0071630biological_processnuclear protein quality control by the ubiquitin-proteasome system
C0072576biological_processliver morphogenesis
C0072686cellular_componentmitotic spindle
C0080090biological_processregulation of primary metabolic process
C0097193biological_processintrinsic apoptotic signaling pathway
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0140252biological_processregulation protein catabolic process at postsynapse
C0160072molecular_functionubiquitin ligase complex scaffold activity
C0160240biological_processRNA polymerase II transcription initiation surveillance
C1900076biological_processregulation of cellular response to insulin stimulus
C1901992biological_processpositive regulation of mitotic cell cycle phase transition
C1904262biological_processnegative regulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
E0000045biological_processautophagosome assembly
E0000082biological_processG1/S transition of mitotic cell cycle
E0000165biological_processMAPK cascade
E0000209biological_processprotein polyubiquitination
E0000423biological_processmitophagy
E0001837biological_processepithelial to mesenchymal transition
E0004842molecular_functionubiquitin-protein transferase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006281biological_processDNA repair
E0006283biological_processtranscription-coupled nucleotide-excision repair
E0006366biological_processtranscription by RNA polymerase II
E0006368biological_processtranscription elongation by RNA polymerase II
E0006511biological_processubiquitin-dependent protein catabolic process
E0006513biological_processprotein monoubiquitination
E0006915biological_processapoptotic process
E0006974biological_processDNA damage response
E0006979biological_processresponse to oxidative stress
E0007040biological_processlysosome organization
E0007283biological_processspermatogenesis
E0007346biological_processregulation of mitotic cell cycle
E0008270molecular_functionzinc ion binding
E0008286biological_processinsulin receptor signaling pathway
E0010507biological_processnegative regulation of autophagy
E0010508biological_processpositive regulation of autophagy
E0016567biological_processprotein ubiquitination
E0016740molecular_functiontransferase activity
E0019005cellular_componentSCF ubiquitin ligase complex
E0019221biological_processcytokine-mediated signaling pathway
E0019788molecular_functionNEDD8 transferase activity
E0030163biological_processprotein catabolic process
E0030330biological_processDNA damage response, signal transduction by p53 class mediator
E0030891cellular_componentVCB complex
E0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E0031461cellular_componentcullin-RING ubiquitin ligase complex
E0031462cellular_componentCul2-RING ubiquitin ligase complex
E0031463cellular_componentCul3-RING ubiquitin ligase complex
E0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
E0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
E0031466cellular_componentCul5-RING ubiquitin ligase complex
E0031467cellular_componentCul7-RING ubiquitin ligase complex
E0031625molecular_functionubiquitin protein ligase binding
E0031669biological_processcellular response to nutrient levels
E0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
E0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
E0032480biological_processnegative regulation of type I interferon production
E0032481biological_processpositive regulation of type I interferon production
E0032869biological_processcellular response to insulin stimulus
E0034198biological_processcellular response to amino acid starvation
E0034450molecular_functionubiquitin-ubiquitin ligase activity
E0034599biological_processcellular response to oxidative stress
E0034644biological_processcellular response to UV
E0035279biological_processmiRNA-mediated gene silencing by mRNA destabilization
E0038066biological_processp38MAPK cascade
E0038202biological_processTORC1 signaling
E0042110biological_processT cell activation
E0042770biological_processsignal transduction in response to DNA damage
E0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
E0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0043687biological_processpost-translational protein modification
E0044877molecular_functionprotein-containing complex binding
E0045116biological_processprotein neddylation
E0045727biological_processpositive regulation of translation
E0045732biological_processpositive regulation of protein catabolic process
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0046627biological_processnegative regulation of insulin receptor signaling pathway
E0046872molecular_functionmetal ion binding
E0060090molecular_functionmolecular adaptor activity
E0060337biological_processtype I interferon-mediated signaling pathway
E0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
E0061630molecular_functionubiquitin protein ligase activity
E0061663molecular_functionNEDD8 ligase activity
E0062197biological_processcellular response to chemical stress
E0070294biological_processrenal sodium ion absorption
E0070936biological_processprotein K48-linked ubiquitination
E0071230biological_processcellular response to amino acid stimulus
E0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
E0090090biological_processnegative regulation of canonical Wnt signaling pathway
E0090734cellular_componentsite of DNA damage
E0097510biological_processbase-excision repair, AP site formation via deaminated base removal
E0097602molecular_functioncullin family protein binding
E0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E0160240biological_processRNA polymerase II transcription initiation surveillance
E1900076biological_processregulation of cellular response to insulin stimulus
E1901525biological_processnegative regulation of mitophagy
E1901797biological_processnegative regulation of signal transduction by p53 class mediator
E1902499biological_processpositive regulation of protein autoubiquitination
E1902883biological_processnegative regulation of response to oxidative stress
E1904037biological_processpositive regulation of epithelial cell apoptotic process
E1904262biological_processnegative regulation of TORC1 signaling
E1904263biological_processpositive regulation of TORC1 signaling
E2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkrIegLIEReYLaRtpedrkvYtYvA
ChainResidueDetails
CILE741-ALA768
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues37
DetailsRepeat: {"description":"HEAT 2"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues34
DetailsRepeat: {"description":"HEAT 4"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues34
DetailsRepeat: {"description":"HEAT 7"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues37
DetailsRepeat: {"description":"HEAT 9"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues43
DetailsRepeat: {"description":"HEAT 10"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues39
DetailsRepeat: {"description":"HEAT 11"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues37
DetailsRepeat: {"description":"HEAT 12"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues39
DetailsRepeat: {"description":"HEAT 13"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues37
DetailsRepeat: {"description":"HEAT 14"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues37
DetailsRepeat: {"description":"HEAT 15"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues37
DetailsRepeat: {"description":"HEAT 16"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues39
DetailsRepeat: {"description":"HEAT 17"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues38
DetailsRepeat: {"description":"HEAT 18"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues36
DetailsRepeat: {"description":"HEAT 19"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues37
DetailsRepeat: {"description":"HEAT 20"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues37
DetailsRepeat: {"description":"HEAT 21"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues32
DetailsRepeat: {"description":"HEAT 22"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues37
DetailsRepeat: {"description":"HEAT 23"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues37
DetailsRepeat: {"description":"HEAT 24"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues54
DetailsRepeat: {"description":"HEAT 25"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues34
DetailsRepeat: {"description":"HEAT 26"}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues49
DetailsRepeat: {"description":"HEAT 27"}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues62
DetailsDomain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues21
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues16
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"UniProtKB","id":"Q13616","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues45
DetailsZinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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