Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8H0I

Cryo-EM structure of APOBEC3G-Vif complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
B	0003824	molecular_function	catalytic activity
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
C	0019058	biological_process	viral life cycle
D	0003713	molecular_function	transcription coactivator activity
D	0005634	cellular_component	nucleus
E	0019058	biological_process	viral life cycle
F	0003713	molecular_function	transcription coactivator activity
F	0005634	cellular_component	nucleus
G	0019058	biological_process	viral life cycle
H	0003713	molecular_function	transcription coactivator activity
H	0005634	cellular_component	nucleus
I	0019058	biological_process	viral life cycle
J	0003713	molecular_function	transcription coactivator activity
J	0005634	cellular_component	nucleus

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElcFLdvipfwkldldqdyrvtcftsws..........PCfs......CaqeM

Chain	Residue	Details
A	HIS240-MET278

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18288108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18849968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19153609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25542899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36754086","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36754086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37419875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8H0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J62","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18288108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18849968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19153609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25542899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36754086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37419875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8H0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J62","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKA","evidences":[{"source":"PubMed","id":"18836454","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21659520","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKA and CAMK2","evidences":[{"source":"PubMed","id":"21659520","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	10
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19887642","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253590","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253590","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19887642","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Region: {"description":"Interaction with host APOBEC3F; F1-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	16
Details	Region: {"description":"Interaction with host APOBEC3G; G-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	72
Details	Region: {"description":"Interaction with host APOBEC3F and APOBEC3G; FG-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	20
Details	Region: {"description":"Interaction with host APOBEC3F; F2-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Region: {"description":"Membrane association","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24402281","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37640699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4N9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)