8H0I
Cryo-EM structure of APOBEC3G-Vif complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0019058 | biological_process | viral life cycle |
| D | 0003713 | molecular_function | transcription coactivator activity |
| D | 0005634 | cellular_component | nucleus |
| E | 0019058 | biological_process | viral life cycle |
| F | 0003713 | molecular_function | transcription coactivator activity |
| F | 0005634 | cellular_component | nucleus |
| G | 0019058 | biological_process | viral life cycle |
| H | 0003713 | molecular_function | transcription coactivator activity |
| H | 0005634 | cellular_component | nucleus |
| I | 0019058 | biological_process | viral life cycle |
| J | 0003713 | molecular_function | transcription coactivator activity |
| J | 0005634 | cellular_component | nucleus |
Functional Information from PROSITE/UniProt
| site_id | PS00903 |
| Number of Residues | 39 |
| Details | CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElcFLdvipfwkldldqdyrvtcftsws..........PCfs......CaqeM |
| Chain | Residue | Details |
| A | HIS240-MET278 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24402281, ECO:0000269|PubMed:37640699, ECO:0007744|PDB:4N9F, ECO:0007744|PDB:8FVI |
| Chain | Residue | Details |
| C | HIS108 | |
| G | GLU152 | |
| G | GLU171 | |
| I | HIS108 | |
| I | GLU152 | |
| I | GLU171 | |
| C | GLU152 | |
| C | GLU171 | |
| E | HIS108 | |
| E | GLU152 | |
| E | GLU171 | |
| G | HIS108 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Cleavage in virion (by viral protease) => ECO:0000255|HAMAP-Rule:MF_04081, ECO:0000269|PubMed:12186895 |
| Chain | Residue | Details |
| A | GLU55 | |
| A | CYS87 | |
| A | ASP90 | |
| B | GLU55 | |
| B | CYS87 | |
| B | ASP90 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by host MAP4K1 => ECO:0000255|HAMAP-Rule:MF_04081 |
| Chain | Residue | Details |
| C | THR96 | |
| E | THR96 | |
| G | THR96 | |
| I | THR96 | |
| B | MET278 | |
| B | PHE281 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by host => ECO:0000255|HAMAP-Rule:MF_04081 |
| Chain | Residue | Details |
| A | GLY234 | |
| B | GLY234 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by host MAP4K1 => ECO:0000255|HAMAP-Rule:MF_04081 |
| Chain | Residue | Details |
| A | THR21 | |
| B | THR21 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKA and CAMK2 => ECO:0000269|PubMed:21659520 |
| Chain | Residue | Details |
| A | GLU208 | |
| B | GLU208 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:23318957 |
| Chain | Residue | Details |
| A | ASP32 | |
| B | TYR260 | |
| A | HIS42 | |
| A | PHE140 | |
| A | ALA153 | |
| A | TYR260 | |
| B | ASP32 | |
| B | HIS42 | |
| B | PHE140 | |
| B | ALA153 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:19887642, ECO:0000305|PubMed:23318957, ECO:0000305|PubMed:31253590 |
| Chain | Residue | Details |
| A | HIS287 | |
| A | LYS293 | |
| A | SER324 | |
| B | HIS287 | |
| B | LYS293 | |
| B | SER324 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:23318957, ECO:0000305|PubMed:31253590 |
| Chain | Residue | Details |
| A | HIS53 | |
| A | ARG239 | |
| B | HIS53 | |
| B | ARG239 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:19887642 |
| Chain | Residue | Details |
| A | CYS291 | |
| B | CYS291 |
