8GYT
Cryo-EM structure of human Pannexin-3 R36S/F40R variant in pre-open state.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1547 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-LYS39 | |
| A | ALA135-LEU215 | |
| A | TYR289-PRO392 | |
| B | MET1-LYS39 | |
| B | ALA135-LEU215 | |
| B | TYR289-PRO392 | |
| C | MET1-LYS39 | |
| C | ALA135-LEU215 | |
| C | TYR289-PRO392 | |
| D | MET1-LYS39 | |
| D | ALA135-LEU215 | |
| D | TYR289-PRO392 | |
| E | MET1-LYS39 | |
| E | ALA135-LEU215 | |
| E | TYR289-PRO392 | |
| F | MET1-LYS39 | |
| F | ALA135-LEU215 | |
| F | TYR289-PRO392 | |
| G | MET1-LYS39 | |
| G | ALA135-LEU215 | |
| G | TYR289-PRO392 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 560 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00351 |
| Chain | Residue | Details |
| A | ARG40-SER60 | |
| A | LEU114-PRO134 | |
| A | LEU216-PHE236 | |
| A | ILE268-ILE288 | |
| B | ARG40-SER60 | |
| B | LEU114-PRO134 | |
| B | LEU216-PHE236 | |
| B | ILE268-ILE288 | |
| C | ARG40-SER60 | |
| C | LEU114-PRO134 | |
| C | LEU216-PHE236 | |
| C | ILE268-ILE288 | |
| D | ARG40-SER60 | |
| D | LEU114-PRO134 | |
| D | LEU216-PHE236 | |
| D | ILE268-ILE288 | |
| E | ARG40-SER60 | |
| E | LEU114-PRO134 | |
| E | LEU216-PHE236 | |
| E | ILE268-ILE288 | |
| F | ARG40-SER60 | |
| F | LEU114-PRO134 | |
| F | LEU216-PHE236 | |
| F | ILE268-ILE288 | |
| G | ARG40-SER60 | |
| G | LEU114-PRO134 | |
| G | LEU216-PHE236 | |
| G | ILE268-ILE288 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 574 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY61-SER113 | |
| A | GLN237-SER267 | |
| B | GLY61-SER113 | |
| B | GLN237-SER267 | |
| C | GLY61-SER113 | |
| C | GLN237-SER267 | |
| D | GLY61-SER113 | |
| D | GLN237-SER267 | |
| E | GLY61-SER113 | |
| E | GLN237-SER267 | |
| F | GLY61-SER113 | |
| F | GLN237-SER267 | |
| G | GLY61-SER113 | |
| G | GLN237-SER267 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN71 | |
| B | ASN71 | |
| C | ASN71 | |
| D | ASN71 | |
| E | ASN71 | |
| F | ASN71 | |
| G | ASN71 |
