8GYQ

Cryo-EM structure of human Pannexin-2 in pre-open state.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0005198	molecular_function	structural molecule activity
A	0005243	molecular_function	gap junction channel activity
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0007267	biological_process	cell-cell signaling
A	0015267	molecular_function	channel activity
A	0022829	molecular_function	wide pore channel activity
A	0032732	biological_process	positive regulation of interleukin-1 production
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0044877	molecular_function	protein-containing complex binding
A	0055077	molecular_function	gap junction hemi-channel activity
B	0000139	cellular_component	Golgi membrane
B	0005198	molecular_function	structural molecule activity
B	0005243	molecular_function	gap junction channel activity
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0007267	biological_process	cell-cell signaling
B	0015267	molecular_function	channel activity
B	0022829	molecular_function	wide pore channel activity
B	0032732	biological_process	positive regulation of interleukin-1 production
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0044877	molecular_function	protein-containing complex binding
B	0055077	molecular_function	gap junction hemi-channel activity
C	0000139	cellular_component	Golgi membrane
C	0005198	molecular_function	structural molecule activity
C	0005243	molecular_function	gap junction channel activity
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0007267	biological_process	cell-cell signaling
C	0015267	molecular_function	channel activity
C	0022829	molecular_function	wide pore channel activity
C	0032732	biological_process	positive regulation of interleukin-1 production
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0044877	molecular_function	protein-containing complex binding
C	0055077	molecular_function	gap junction hemi-channel activity
D	0000139	cellular_component	Golgi membrane
D	0005198	molecular_function	structural molecule activity
D	0005243	molecular_function	gap junction channel activity
D	0005737	cellular_component	cytoplasm
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0007267	biological_process	cell-cell signaling
D	0015267	molecular_function	channel activity
D	0022829	molecular_function	wide pore channel activity
D	0032732	biological_process	positive regulation of interleukin-1 production
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0044877	molecular_function	protein-containing complex binding
D	0055077	molecular_function	gap junction hemi-channel activity
E	0000139	cellular_component	Golgi membrane
E	0005198	molecular_function	structural molecule activity
E	0005243	molecular_function	gap junction channel activity
E	0005737	cellular_component	cytoplasm
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006812	biological_process	monoatomic cation transport
E	0007267	biological_process	cell-cell signaling
E	0015267	molecular_function	channel activity
E	0022829	molecular_function	wide pore channel activity
E	0032732	biological_process	positive regulation of interleukin-1 production
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0044877	molecular_function	protein-containing complex binding
E	0055077	molecular_function	gap junction hemi-channel activity
F	0000139	cellular_component	Golgi membrane
F	0005198	molecular_function	structural molecule activity
F	0005243	molecular_function	gap junction channel activity
F	0005737	cellular_component	cytoplasm
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006812	biological_process	monoatomic cation transport
F	0007267	biological_process	cell-cell signaling
F	0015267	molecular_function	channel activity
F	0022829	molecular_function	wide pore channel activity
F	0032732	biological_process	positive regulation of interleukin-1 production
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0044877	molecular_function	protein-containing complex binding
F	0055077	molecular_function	gap junction hemi-channel activity
G	0000139	cellular_component	Golgi membrane
G	0005198	molecular_function	structural molecule activity
G	0005243	molecular_function	gap junction channel activity
G	0005737	cellular_component	cytoplasm
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006812	biological_process	monoatomic cation transport
G	0007267	biological_process	cell-cell signaling
G	0015267	molecular_function	channel activity
G	0022829	molecular_function	wide pore channel activity
G	0032732	biological_process	positive regulation of interleukin-1 production
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0044877	molecular_function	protein-containing complex binding
G	0055077	molecular_function	gap junction hemi-channel activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	616
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00351","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	658
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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