8GYO
Inner channel lipids regulated gating mechanism of human pannexins.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1862 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-CYS40 | |
| A | ARG128-ARG217 | |
| A | ALA288-CYS426 | |
| B | MET1-CYS40 | |
| B | ARG128-ARG217 | |
| B | ALA288-CYS426 | |
| C | MET1-CYS40 | |
| C | ARG128-ARG217 | |
| C | ALA288-CYS426 | |
| D | MET1-CYS40 | |
| D | ARG128-ARG217 | |
| D | ALA288-CYS426 | |
| E | MET1-CYS40 | |
| E | ARG128-ARG217 | |
| E | ALA288-CYS426 | |
| F | MET1-CYS40 | |
| F | ARG128-ARG217 | |
| F | ALA288-CYS426 | |
| G | MET1-CYS40 | |
| G | ARG128-ARG217 | |
| G | ALA288-CYS426 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 560 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00351 |
| Chain | Residue | Details |
| A | ILE41-GLY61 | |
| A | LYS107-TRP127 | |
| A | LEU218-SER238 | |
| A | LEU267-LEU287 | |
| B | ILE41-GLY61 | |
| B | LYS107-TRP127 | |
| B | LEU218-SER238 | |
| B | LEU267-LEU287 | |
| C | ILE41-GLY61 | |
| C | LYS107-TRP127 | |
| C | LEU218-SER238 | |
| C | LEU267-LEU287 | |
| D | ILE41-GLY61 | |
| D | LYS107-TRP127 | |
| D | LEU218-SER238 | |
| D | LEU267-LEU287 | |
| E | ILE41-GLY61 | |
| E | LYS107-TRP127 | |
| E | LEU218-SER238 | |
| E | LEU267-LEU287 | |
| F | ILE41-GLY61 | |
| F | LYS107-TRP127 | |
| F | LEU218-SER238 | |
| F | LEU267-LEU287 | |
| G | ILE41-GLY61 | |
| G | LYS107-TRP127 | |
| G | LEU218-SER238 | |
| G | LEU267-LEU287 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 497 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | THR62-HIS106 | |
| A | SER239-LYS266 | |
| B | THR62-HIS106 | |
| B | SER239-LYS266 | |
| C | THR62-HIS106 | |
| C | SER239-LYS266 | |
| D | THR62-HIS106 | |
| D | SER239-LYS266 | |
| E | THR62-HIS106 | |
| E | SER239-LYS266 | |
| F | THR62-HIS106 | |
| F | SER239-LYS266 | |
| G | THR62-HIS106 | |
| G | SER239-LYS266 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | SITE: Cleavage; by CASP3 or CASP7 => ECO:0000269|PubMed:20944749 |
| Chain | Residue | Details |
| A | ASP376 | |
| B | ASP376 | |
| C | ASP376 | |
| D | ASP376 | |
| E | ASP376 | |
| F | ASP376 | |
| G | ASP376 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q9JIP4 |
| Chain | Residue | Details |
| A | CYS40 | |
| A | CYS347 | |
| B | CYS40 | |
| B | CYS347 | |
| C | CYS40 | |
| C | CYS347 | |
| D | CYS40 | |
| D | CYS347 | |
| E | CYS40 | |
| E | CYS347 | |
| F | CYS40 | |
| F | CYS347 | |
| G | CYS40 | |
| G | CYS347 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:30814251 |
| Chain | Residue | Details |
| A | TYR199 | |
| B | TYR199 | |
| C | TYR199 | |
| D | TYR199 | |
| E | TYR199 | |
| F | TYR199 | |
| G | TYR199 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17715132, ECO:0000269|PubMed:30918116, ECO:0000269|PubMed:32494015, ECO:0000269|PubMed:33947837 |
| Chain | Residue | Details |
| A | ASN255 | |
| B | ASN255 | |
| C | ASN255 | |
| D | ASN255 | |
| E | ASN255 | |
| F | ASN255 | |
| G | ASN255 |
