8GWR
Near full length Kidney type Glutaminase in complex with 2,2-Dimethyl-2,3-Dihydrobenzo[a] Phenanthridin-4(1H)-one (DDP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004359 | molecular_function | glutaminase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006537 | biological_process | obsolete glutamate biosynthetic process |
| A | 0006541 | biological_process | glutamine metabolic process |
| A | 0006543 | biological_process | L-glutamine catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0090461 | biological_process | intracellular glutamate homeostasis |
| B | 0004359 | molecular_function | glutaminase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006537 | biological_process | obsolete glutamate biosynthetic process |
| B | 0006541 | biological_process | glutamine metabolic process |
| B | 0006543 | biological_process | L-glutamine catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0090461 | biological_process | intracellular glutamate homeostasis |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"Highly mobile activation loop","evidences":[{"source":"UniProtKB","id":"D3Z7P3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22049910","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22538822","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24451979","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3CZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UNW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VP1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"D3Z7P3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
