8GTK
Crystal structure of IpaH7.8-LRR and GSDMB isoform-1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0012501 | biological_process | programmed cell death |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0070269 | biological_process | pyroptotic inflammatory response |
| A | 0070273 | molecular_function | phosphatidylinositol-4-phosphate binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 71 |
| Details | TRANSMEM: Beta stranded => ECO:0000269|PubMed:36991122, ECO:0000269|PubMed:36991125, ECO:0007744|PDB:8EFP, ECO:0007744|PDB:8ET1, ECO:0007744|PDB:8ET2, ECO:0007744|PDB:8GTJ, ECO:0007744|PDB:8GTN |
| Chain | Residue | Details |
| A | LEU83-HIS101 | |
| A | HIS102-LEU125 | |
| A | SER167-GLU183 | |
| A | VAL184-GLN198 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by CAPS3, CAPS6 and CAPS9 => ECO:0000305|PubMed:28154144 |
| Chain | Residue | Details |
| A | ILE91 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by ELANE => ECO:0000269|PubMed:36899106 |
| Chain | Residue | Details |
| A | LEU220 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by granzyme A => ECO:0000269|PubMed:32299851 |
| Chain | Residue | Details |
| A | LYS229 | |
| A | GLU244 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36991122 |
| Chain | Residue | Details |
| A | LYS177 | |
| A | ARG190 | |
| A | LEU192 |
