8GT7
Structure of falcipain and human Stefin A mutant complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0001533 | cellular_component | cornified envelope |
| B | 0002020 | molecular_function | protease binding |
| B | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0007155 | biological_process | cell adhesion |
| B | 0018149 | biological_process | peptide cross-linking |
| B | 0030216 | biological_process | keratinocyte differentiation |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0045861 | biological_process | negative regulation of proteolysis |
| B | 0098609 | biological_process | cell-cell adhesion |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0001533 | cellular_component | cornified envelope |
| D | 0002020 | molecular_function | protease binding |
| D | 0004866 | molecular_function | endopeptidase inhibitor activity |
| D | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0007155 | biological_process | cell adhesion |
| D | 0018149 | biological_process | peptide cross-linking |
| D | 0030216 | biological_process | keratinocyte differentiation |
| D | 0030414 | molecular_function | peptidase inhibitor activity |
| D | 0045861 | biological_process | negative regulation of proteolysis |
| D | 0098609 | biological_process | cell-cell adhesion |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QKnCGSCWAfSS |
| Chain | Residue | Details |
| A | GLN36-SER47 |
| site_id | PS00287 |
| Number of Residues | 14 |
| Details | CYSTATIN Cysteine proteases inhibitors signature. TQVVAGTNYyIKVR |
| Chain | Residue | Details |
| B | THR45-ARG58 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVMLVGFG |
| Chain | Residue | Details |
| A | LEU172-GLY182 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | Motif: {"description":"Nose motif; required for the correct folding of the mature form","evidences":[{"source":"PubMed","id":"11827964","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Motif: {"description":"Arm motif; binds to host hemoglobin and required for the inhibitory interaction between the propeptide and the catalytic domain","evidences":[{"source":"PubMed","id":"15964982","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Secondary area of contact"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"Reactive site"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P01039","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
