8GT7

Structure of falcipain and human Stefin A mutant complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0001533	cellular_component	cornified envelope
B	0002020	molecular_function	protease binding
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007155	biological_process	cell adhesion
B	0010466	biological_process	negative regulation of peptidase activity
B	0018149	biological_process	peptide cross-linking
B	0030216	biological_process	keratinocyte differentiation
B	0045861	biological_process	negative regulation of proteolysis
B	0098609	biological_process	cell-cell adhesion
B	1904090	cellular_component	peptidase inhibitor complex
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0001533	cellular_component	cornified envelope
D	0002020	molecular_function	protease binding
D	0004866	molecular_function	endopeptidase inhibitor activity
D	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007155	biological_process	cell adhesion
D	0010466	biological_process	negative regulation of peptidase activity
D	0018149	biological_process	peptide cross-linking
D	0030216	biological_process	keratinocyte differentiation
D	0045861	biological_process	negative regulation of proteolysis
D	0098609	biological_process	cell-cell adhesion
D	1904090	cellular_component	peptidase inhibitor complex

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QKnCGSCWAfSS

Chain	Residue	Details
A	GLN36-SER47

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site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVMLVGFG

Chain	Residue	Details
A	LEU172-GLY182

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site_id	PS00287
Number of Residues	14
Details	CYSTATIN Cysteine proteases inhibitors signature. TQVVAGTNYyIKVR

Chain	Residue	Details
B	THR45-ARG58

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Reactive site

Chain	Residue	Details
B	GLY4
D	GLY4

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P01039

Chain	Residue	Details
B	MET1
D	MET1

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site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090

Chain	Residue	Details
A	ASN204
C	ASN204

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