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8GSS

Human glutathione S-transferase P1-1, complex with glutathione

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0002674biological_processnegative regulation of acute inflammatory response
A0004364molecular_functionglutathione transferase activity
A0004602molecular_functionglutathione peroxidase activity
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006629biological_processlipid metabolic process
A0006693biological_processprostaglandin metabolic process
A0006749biological_processglutathione metabolic process
A0006805biological_processxenobiotic metabolic process
A0007417biological_processcentral nervous system development
A0008432molecular_functionJUN kinase binding
A0009890biological_processnegative regulation of biosynthetic process
A0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
A0016740molecular_functiontransferase activity
A0019207molecular_functionkinase regulator activity
A0031982cellular_componentvesicle
A0032691biological_processnegative regulation of interleukin-1 beta production
A0032720biological_processnegative regulation of tumor necrosis factor production
A0032872biological_processregulation of stress-activated MAPK cascade
A0032873biological_processnegative regulation of stress-activated MAPK cascade
A0032930biological_processpositive regulation of superoxide anion generation
A0034774cellular_componentsecretory granule lumen
A0035726biological_processcommon myeloid progenitor cell proliferation
A0035730molecular_functionS-nitrosoglutathione binding
A0035731molecular_functiondinitrosyl-iron complex binding
A0035732biological_processnitric oxide storage
A0043066biological_processnegative regulation of apoptotic process
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043407biological_processnegative regulation of MAP kinase activity
A0043409biological_processnegative regulation of MAPK cascade
A0043508biological_processnegative regulation of JUN kinase activity
A0043651biological_processlinoleic acid metabolic process
A0048147biological_processnegative regulation of fibroblast proliferation
A0051122biological_processhepoxilin biosynthetic process
A0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
A0070026molecular_functionnitric oxide binding
A0070062cellular_componentextracellular exosome
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0070664biological_processnegative regulation of leukocyte proliferation
A0071222biological_processcellular response to lipopolysaccharide
A0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
A0097057cellular_componentTRAF2-GSTP1 complex
A0098869biological_processcellular oxidant detoxification
A1901687biological_processglutathione derivative biosynthetic process
A1904813cellular_componentficolin-1-rich granule lumen
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0000302biological_processresponse to reactive oxygen species
B0002674biological_processnegative regulation of acute inflammatory response
B0004364molecular_functionglutathione transferase activity
B0004602molecular_functionglutathione peroxidase activity
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006629biological_processlipid metabolic process
B0006693biological_processprostaglandin metabolic process
B0006749biological_processglutathione metabolic process
B0006805biological_processxenobiotic metabolic process
B0007417biological_processcentral nervous system development
B0008432molecular_functionJUN kinase binding
B0009890biological_processnegative regulation of biosynthetic process
B0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
B0016740molecular_functiontransferase activity
B0019207molecular_functionkinase regulator activity
B0031982cellular_componentvesicle
B0032691biological_processnegative regulation of interleukin-1 beta production
B0032720biological_processnegative regulation of tumor necrosis factor production
B0032872biological_processregulation of stress-activated MAPK cascade
B0032873biological_processnegative regulation of stress-activated MAPK cascade
B0032930biological_processpositive regulation of superoxide anion generation
B0034774cellular_componentsecretory granule lumen
B0035726biological_processcommon myeloid progenitor cell proliferation
B0035730molecular_functionS-nitrosoglutathione binding
B0035731molecular_functiondinitrosyl-iron complex binding
B0035732biological_processnitric oxide storage
B0043066biological_processnegative regulation of apoptotic process
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043407biological_processnegative regulation of MAP kinase activity
B0043409biological_processnegative regulation of MAPK cascade
B0043508biological_processnegative regulation of JUN kinase activity
B0043651biological_processlinoleic acid metabolic process
B0048147biological_processnegative regulation of fibroblast proliferation
B0051122biological_processhepoxilin biosynthetic process
B0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
B0070026molecular_functionnitric oxide binding
B0070062cellular_componentextracellular exosome
B0070372biological_processregulation of ERK1 and ERK2 cascade
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0070664biological_processnegative regulation of leukocyte proliferation
B0071222biological_processcellular response to lipopolysaccharide
B0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
B0097057cellular_componentTRAF2-GSTP1 complex
B0098869biological_processcellular oxidant detoxification
B1901687biological_processglutathione derivative biosynthetic process
B1904813cellular_componentficolin-1-rich granule lumen
B2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
C0000302biological_processresponse to reactive oxygen species
C0002674biological_processnegative regulation of acute inflammatory response
C0004364molecular_functionglutathione transferase activity
C0004602molecular_functionglutathione peroxidase activity
C0005504molecular_functionfatty acid binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006469biological_processnegative regulation of protein kinase activity
C0006629biological_processlipid metabolic process
C0006693biological_processprostaglandin metabolic process
C0006749biological_processglutathione metabolic process
C0006805biological_processxenobiotic metabolic process
C0007417biological_processcentral nervous system development
C0008432molecular_functionJUN kinase binding
C0009890biological_processnegative regulation of biosynthetic process
C0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
C0016740molecular_functiontransferase activity
C0019207molecular_functionkinase regulator activity
C0031982cellular_componentvesicle
C0032691biological_processnegative regulation of interleukin-1 beta production
C0032720biological_processnegative regulation of tumor necrosis factor production
C0032872biological_processregulation of stress-activated MAPK cascade
C0032873biological_processnegative regulation of stress-activated MAPK cascade
C0032930biological_processpositive regulation of superoxide anion generation
C0034774cellular_componentsecretory granule lumen
C0035726biological_processcommon myeloid progenitor cell proliferation
C0035730molecular_functionS-nitrosoglutathione binding
C0035731molecular_functiondinitrosyl-iron complex binding
C0035732biological_processnitric oxide storage
C0043066biological_processnegative regulation of apoptotic process
C0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
C0043407biological_processnegative regulation of MAP kinase activity
C0043409biological_processnegative regulation of MAPK cascade
C0043508biological_processnegative regulation of JUN kinase activity
C0043651biological_processlinoleic acid metabolic process
C0048147biological_processnegative regulation of fibroblast proliferation
C0051122biological_processhepoxilin biosynthetic process
C0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
C0070026molecular_functionnitric oxide binding
C0070062cellular_componentextracellular exosome
C0070372biological_processregulation of ERK1 and ERK2 cascade
C0070373biological_processnegative regulation of ERK1 and ERK2 cascade
C0070664biological_processnegative regulation of leukocyte proliferation
C0071222biological_processcellular response to lipopolysaccharide
C0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
C0097057cellular_componentTRAF2-GSTP1 complex
C0098869biological_processcellular oxidant detoxification
C1901687biological_processglutathione derivative biosynthetic process
C1904813cellular_componentficolin-1-rich granule lumen
C2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE SO4 C 210
ChainResidue
CASN66
CHOH213
CHOH384
CHOH384
CASN66
CARG70
CARG70
CASP94
CASP94
CGLU97
CGLU97
CHOH213

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE SO4 A 210
ChainResidue
AASN66
AARG70
AASP94
AGLU97
AHOH248
AHOH293
AHOH371
BARG70
BASP94
BGLU97
BHOH213

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GSH A 211
ChainResidue
APHE8
AARG13
ATRP38
ALYS44
AGLN51
ALEU52
APRO53
AGLN64
ASER65
AHOH232
AHOH243
AHOH299
AHOH355
BASP98

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE GSH B 210
ChainResidue
AASP98
BPHE8
BARG13
BTRP38
BLYS44
BGLN51
BLEU52
BPRO53
BGLN64
BSER65
BHOH256
BHOH257
BHOH283
BHOH288
BHOH304
BHOH341

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MES B 211
ChainResidue
BTRP28
BGLU30
BPHE192
BGLU197
BHOH367

site_idAC6
Number of Residues16
DetailsBINDING SITE FOR RESIDUE GSH C 211
ChainResidue
CPHE8
CARG13
CTRP38
CLYS44
CGLY50
CGLN51
CLEU52
CPRO53
CGLN64
CSER65
CASP98
CHOH224
CHOH241
CHOH276
CHOH360
CHOH416

site_idAC7
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MES C 212
ChainResidue
CARG74
CARG74
CTYR79
CTYR79
CGLY80
CLYS81
CASP82
CGLN83
CALA86
CHOH412

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518
ChainResidueDetails
CPHE8
CCYS14
CGLN39
CALA45
CLEU52
CSER65
APHE8
ACYS14
AGLN39
AALA45
ALEU52
ASER65
BPHE8
BCYS14
BGLN39
BALA45
BLEU52
BSER65

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by EGFR => ECO:0000269|PubMed:19254954
ChainResidueDetails
ATHR4
AVAL199
BTHR4
BVAL199
CTHR4
CVAL199

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ALEU62
BLEU62
CLEU62

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P19157
ChainResidueDetails
ATYR103
AASP116
BTYR103
BASP116
CTYR103
CASP116

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
APRO128
BPRO128
CPRO128

221051

PDB entries from 2024-06-12

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