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8GS8

cryo-EM structure of the human respiratory complex II

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005730cellular_componentnucleolus
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005749cellular_componentobsolete mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
A0005759cellular_componentmitochondrial matrix
A0006099biological_processtricarboxylic acid cycle
A0006105biological_processsuccinate metabolic process
A0006121biological_processmitochondrial electron transport, succinate to ubiquinone
A0007399biological_processnervous system development
A0008177molecular_functionsuccinate dehydrogenase (quinone) activity
A0009055molecular_functionelectron transfer activity
A0016491molecular_functionoxidoreductase activity
A0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
A0022900biological_processelectron transport chain
A0022904biological_processrespiratory electron transport chain
A0042776biological_processproton motive force-driven mitochondrial ATP synthesis
A0045257cellular_componentobsolete succinate dehydrogenase complex (ubiquinone)
A0045273cellular_componentrespiratory chain complex II (succinate dehydrogenase)
A0050660molecular_functionflavin adenine dinucleotide binding
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005749cellular_componentobsolete mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
B0005759cellular_componentmitochondrial matrix
B0005886cellular_componentplasma membrane
B0006099biological_processtricarboxylic acid cycle
B0006121biological_processmitochondrial electron transport, succinate to ubiquinone
B0008177molecular_functionsuccinate dehydrogenase (quinone) activity
B0009055molecular_functionelectron transfer activity
B0009060biological_processaerobic respiration
B0016491molecular_functionoxidoreductase activity
B0022904biological_processrespiratory electron transport chain
B0031966cellular_componentmitochondrial membrane
B0042776biological_processproton motive force-driven mitochondrial ATP synthesis
B0045257cellular_componentobsolete succinate dehydrogenase complex (ubiquinone)
B0045273cellular_componentrespiratory chain complex II (succinate dehydrogenase)
B0046872molecular_functionmetal ion binding
B0048039molecular_functionubiquinone binding
B0051536molecular_functioniron-sulfur cluster binding
B0051537molecular_function2 iron, 2 sulfur cluster binding
B0051538molecular_function3 iron, 4 sulfur cluster binding
B0051539molecular_function4 iron, 4 sulfur cluster binding
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0005749cellular_componentobsolete mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
C0006099biological_processtricarboxylic acid cycle
C0006121biological_processmitochondrial electron transport, succinate to ubiquinone
C0009055molecular_functionelectron transfer activity
C0009060biological_processaerobic respiration
C0016020cellular_componentmembrane
C0020037molecular_functionheme binding
C0042776biological_processproton motive force-driven mitochondrial ATP synthesis
C0045257cellular_componentobsolete succinate dehydrogenase complex (ubiquinone)
C0045273cellular_componentrespiratory chain complex II (succinate dehydrogenase)
C0045281cellular_componentobsolete succinate dehydrogenase complex
C0046872molecular_functionmetal ion binding
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005740cellular_componentmitochondrial envelope
D0005743cellular_componentmitochondrial inner membrane
D0005749cellular_componentobsolete mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
D0006099biological_processtricarboxylic acid cycle
D0006121biological_processmitochondrial electron transport, succinate to ubiquinone
D0008177molecular_functionsuccinate dehydrogenase (quinone) activity
D0009055molecular_functionelectron transfer activity
D0016020cellular_componentmembrane
D0020037molecular_functionheme binding
D0042776biological_processproton motive force-driven mitochondrial ATP synthesis
D0045257cellular_componentobsolete succinate dehydrogenase complex (ubiquinone)
D0045273cellular_componentrespiratory chain complex II (succinate dehydrogenase)
D0046872molecular_functionmetal ion binding
D0048039molecular_functionubiquinone binding
D0050433biological_processregulation of catecholamine secretion
D0071456biological_processcellular response to hypoxia
Functional Information from PROSITE/UniProt
site_idPS00197
Number of Residues9
Details2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CREGICGSC
ChainResidueDetails
BCYS93-CYS101

site_idPS00198
Number of Residues12
Details4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiLCAcCStSCP
ChainResidueDetails
BCYS186-PRO197

site_idPS00504
Number of Residues10
DetailsFRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvaAqGG
ChainResidueDetails
AARG97-GLY106

site_idPS01000
Number of Residues25
DetailsSDH_CYT_1 Succinate dehydrogenase cytochrome b subunit signature 1. RPLsphItiyswsLpmamSicHRgT
ChainResidueDetails
CARG50-THR74

site_idPS01001
Number of Residues14
DetailsSDH_CYT_2 Succinate dehydrogenase cytochrome b subunit signature 2. HtwnGIRHLmWDlG
ChainResidueDetails
CHIS127-GLY140

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsTOPO_DOM: Mitochondrial matrix => ECO:0000250
ChainResidueDetails
DSER57-SER63
BCYS243
BCYS249
BCYS253
DTHR112-LEU120
BCYS101
BCYS113
BCYS186
BCYS189
BCYS192
BCYS196
BTRP201

site_idSWS_FT_FI2
Number of Residues62
DetailsTRANSMEM: Helical => ECO:0000250
ChainResidueDetails
DLEU64-LEU85
DMET91-VAL111
DGLN121-PHE142
AHIS296
ATHR308
AHIS407
AGLU440
AARG451
ASER456

site_idSWS_FT_FI3
Number of Residues20
DetailsTOPO_DOM: Mitochondrial intermembrane => ECO:0000250
ChainResidueDetails
DASN86-ALA90
DASN143-LEU159

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: axial binding residue => ECO:0000250|UniProtKB:A5GZW8
ChainResidueDetails
DHIS102
ALYS182
ALYS480
ALYS517
ALYS550
ALYS598
ALYS624
ALYS636
ALYS647

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
DTYR114
ALYS250
ALYS335
ALYS485
ALYS498
ALYS538
ALYS547

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:22823520
ChainResidueDetails
ATYR215

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS541
ALYS608

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8K2B3
ChainResidueDetails
ALYS615

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PDB entries from 2024-07-17

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