8GRS
human TMEM63A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034451 | cellular_component | centriolar satellite |
| A | 0035579 | cellular_component | specific granule membrane |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070821 | cellular_component | tertiary granule membrane |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0160069 | biological_process | surfactant secretion |
| A | 1990760 | molecular_function | osmolarity-sensing monoatomic cation channel activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 118 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-PRO51 | |
| A | GLY168-ASP191 | |
| A | THR445-ILE462 | |
| A | PHE533-ALA554 | |
| A | SER625-CYS628 | |
| A | LEU690-ALA694 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 280 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:37543036, ECO:0007744|PDB:8EHW |
| Chain | Residue | Details |
| A | THR52-ARG74 | |
| A | GLY662-ARG689 | |
| A | PRO695-LEU709 | |
| A | ASP135-SER167 | |
| A | LEU192-SER217 | |
| A | ARG417-SER444 | |
| A | ILE463-GLU490 | |
| A | SER496-LEU532 | |
| A | PHE555-ILE586 | |
| A | PHE607-TYR624 | |
| A | PRO629-TYR651 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 386 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | PHE75-GLU134 | |
| A | ILE218-LEU416 | |
| A | SER491-LYS495 | |
| A | MET587-GLU606 | |
| A | PHE652-LYS661 | |
| A | VAL710-ALA807 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91YT8 |
| Chain | Residue | Details |
| A | SER739 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN38 | |
| A | ASN450 |
