8GOC

Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000822	molecular_function	inositol hexakisphosphate binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
A	0002031	biological_process	G protein-coupled receptor internalization
A	0002092	biological_process	positive regulation of receptor internalization
A	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005905	cellular_component	clathrin-coated pit
A	0006898	biological_process	receptor-mediated endocytosis
A	0007165	biological_process	signal transduction
A	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
A	0009968	biological_process	negative regulation of signal transduction
A	0015031	biological_process	protein transport
A	0019233	biological_process	sensory perception of pain
A	0030139	cellular_component	endocytic vesicle
A	0031410	cellular_component	cytoplasmic vesicle
A	0031623	biological_process	receptor internalization
A	0031701	molecular_function	angiotensin receptor binding
A	0031748	molecular_function	D1 dopamine receptor binding
A	0035091	molecular_function	phosphatidylinositol binding
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0000822	molecular_function	inositol hexakisphosphate binding
B	0001664	molecular_function	G protein-coupled receptor binding
B	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
B	0002031	biological_process	G protein-coupled receptor internalization
B	0002092	biological_process	positive regulation of receptor internalization
B	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0005905	cellular_component	clathrin-coated pit
B	0006898	biological_process	receptor-mediated endocytosis
B	0007165	biological_process	signal transduction
B	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
B	0009968	biological_process	negative regulation of signal transduction
B	0015031	biological_process	protein transport
B	0019233	biological_process	sensory perception of pain
B	0030139	cellular_component	endocytic vesicle
B	0031410	cellular_component	cytoplasmic vesicle
B	0031623	biological_process	receptor internalization
B	0031701	molecular_function	angiotensin receptor binding
B	0031748	molecular_function	D1 dopamine receptor binding
B	0035091	molecular_function	phosphatidylinositol binding
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0000822	molecular_function	inositol hexakisphosphate binding
C	0001664	molecular_function	G protein-coupled receptor binding
C	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
C	0002031	biological_process	G protein-coupled receptor internalization
C	0002092	biological_process	positive regulation of receptor internalization
C	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0005905	cellular_component	clathrin-coated pit
C	0006898	biological_process	receptor-mediated endocytosis
C	0007165	biological_process	signal transduction
C	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
C	0009968	biological_process	negative regulation of signal transduction
C	0015031	biological_process	protein transport
C	0019233	biological_process	sensory perception of pain
C	0030139	cellular_component	endocytic vesicle
C	0031410	cellular_component	cytoplasmic vesicle
C	0031623	biological_process	receptor internalization
C	0031701	molecular_function	angiotensin receptor binding
C	0031748	molecular_function	D1 dopamine receptor binding
C	0035091	molecular_function	phosphatidylinositol binding
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
E	TYR193-HIS199
D	TYR204-HIS210

---

site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDcDVLGLsFrKDL

Chain	Residue	Details
A	PHE62-LEU80

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q91YI4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"Hydroxyproline; by PHD2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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