8GNJ
Human SARM1 bounded with NMN and Nanobody-C6, Conformation 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0003953 | molecular_function | NAD+ nucleosidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005874 | cellular_component | microtubule |
| A | 0007165 | biological_process | signal transduction |
| A | 0019677 | biological_process | NAD+ catabolic process |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| A | 0035591 | molecular_function | signaling adaptor activity |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043068 | biological_process | positive regulation of programmed cell death |
| A | 0045202 | cellular_component | synapse |
| A | 0048678 | biological_process | response to axon injury |
| A | 0048814 | biological_process | regulation of dendrite morphogenesis |
| A | 0050135 | molecular_function | NADP+ nucleosidase activity |
| A | 0050877 | biological_process | nervous system process |
| A | 0061809 | molecular_function | NAD+ nucleosidase activity, cyclic ADP-ribose generating |
| A | 0070585 | biological_process | protein localization to mitochondrion |
| B | 0003690 | molecular_function | double-stranded DNA binding |
| B | 0003953 | molecular_function | NAD+ nucleosidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0005874 | cellular_component | microtubule |
| B | 0007165 | biological_process | signal transduction |
| B | 0019677 | biological_process | NAD+ catabolic process |
| B | 0030424 | cellular_component | axon |
| B | 0030425 | cellular_component | dendrite |
| B | 0034128 | biological_process | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| B | 0035591 | molecular_function | signaling adaptor activity |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0043068 | biological_process | positive regulation of programmed cell death |
| B | 0045202 | cellular_component | synapse |
| B | 0048678 | biological_process | response to axon injury |
| B | 0048814 | biological_process | regulation of dendrite morphogenesis |
| B | 0050135 | molecular_function | NADP+ nucleosidase activity |
| B | 0050877 | biological_process | nervous system process |
| B | 0061809 | molecular_function | NAD+ nucleosidase activity, cyclic ADP-ribose generating |
| B | 0070585 | biological_process | protein localization to mitochondrion |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"ARM 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"ARM 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"ARM 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"ARM 6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"ARM 8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 64 |
| Details | Domain: {"description":"SAM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 62 |
| Details | Domain: {"description":"SAM 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33053563","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CM7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30333228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00204","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28334607","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31439792","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31439793","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31439792","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
