8GMR
Cryo-EM structure of octameric human CALHM1
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 368 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | MET1-ASN21 | |
| E | ASN73-MET99 | |
| F | MET1-ASN21 | |
| F | ASN73-MET99 | |
| G | MET1-ASN21 | |
| G | ASN73-MET99 | |
| H | MET1-ASN21 | |
| H | ASN73-MET99 | |
| B | ASN73-MET99 | |
| A | MET1-ASN21 | |
| A | ASN73-MET99 | |
| C | MET1-ASN21 | |
| C | ASN73-MET99 | |
| D | MET1-ASN21 | |
| D | ASN73-MET99 | |
| E | MET1-ASN21 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 120 |
| Details | TRANSMEM: Helical; Name=S1 => ECO:0000250|UniProtKB:H2MCM1, ECO:0000269|PubMed:37380652, ECO:0007744|PDB:8GMP |
| Chain | Residue | Details |
| B | GLY22-ALA37 | |
| A | GLY22-ALA37 | |
| C | GLY22-ALA37 | |
| D | GLY22-ALA37 | |
| E | GLY22-ALA37 | |
| F | GLY22-ALA37 | |
| G | GLY22-ALA37 | |
| H | GLY22-ALA37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 520 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | PHE38-ASN49 | |
| E | LEU126-LEU180 | |
| F | PHE38-ASN49 | |
| F | LEU126-LEU180 | |
| G | PHE38-ASN49 | |
| G | LEU126-LEU180 | |
| H | PHE38-ASN49 | |
| H | LEU126-LEU180 | |
| B | LEU126-LEU180 | |
| A | PHE38-ASN49 | |
| A | LEU126-LEU180 | |
| C | PHE38-ASN49 | |
| C | LEU126-LEU180 | |
| D | PHE38-ASN49 | |
| D | LEU126-LEU180 | |
| E | PHE38-ASN49 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 176 |
| Details | TRANSMEM: Helical; Name=S2 => ECO:0000250|UniProtKB:H2MCM1, ECO:0000269|PubMed:37380652, ECO:0007744|PDB:8GMP |
| Chain | Residue | Details |
| B | ALA50-ASN72 | |
| A | ALA50-ASN72 | |
| C | ALA50-ASN72 | |
| D | ALA50-ASN72 | |
| E | ALA50-ASN72 | |
| F | ALA50-ASN72 | |
| G | ALA50-ASN72 | |
| H | ALA50-ASN72 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 200 |
| Details | TRANSMEM: Helical; Name=S3 => ECO:0000250|UniProtKB:H2MCM1, ECO:0000269|PubMed:37380652, ECO:0007744|PDB:8GMP |
| Chain | Residue | Details |
| B | PHE100-PHE125 | |
| A | PHE100-PHE125 | |
| C | PHE100-PHE125 | |
| D | PHE100-PHE125 | |
| E | PHE100-PHE125 | |
| F | PHE100-PHE125 | |
| G | PHE100-PHE125 | |
| H | PHE100-PHE125 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 200 |
| Details | TRANSMEM: Helical; Name=S4 => ECO:0000250|UniProtKB:H2MCM1, ECO:0000269|PubMed:37380652, ECO:0007744|PDB:8GMP |
| Chain | Residue | Details |
| B | ARG181-ARG206 | |
| A | ARG181-ARG206 | |
| C | ARG181-ARG206 | |
| D | ARG181-ARG206 | |
| E | ARG181-ARG206 | |
| F | ARG181-ARG206 | |
| G | ARG181-ARG206 | |
| H | ARG181-ARG206 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | SITE: Not glycosylated |
| Chain | Residue | Details |
| B | ASN74 | |
| A | ASN74 | |
| C | ASN74 | |
| D | ASN74 | |
| E | ASN74 | |
| F | ASN74 | |
| G | ASN74 | |
| H | ASN74 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:D3Z291 |
| Chain | Residue | Details |
| B | CYS101 | |
| E | CYS208 | |
| F | CYS101 | |
| F | CYS208 | |
| G | CYS101 | |
| G | CYS208 | |
| H | CYS101 | |
| H | CYS208 | |
| B | CYS208 | |
| A | CYS101 | |
| A | CYS208 | |
| C | CYS101 | |
| C | CYS208 | |
| D | CYS101 | |
| D | CYS208 | |
| E | CYS101 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18585350 |
| Chain | Residue | Details |
| B | ASN140 | |
| A | ASN140 | |
| C | ASN140 | |
| D | ASN140 | |
| E | ASN140 | |
| F | ASN140 | |
| G | ASN140 | |
| H | ASN140 |
