Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8GHN

Composite model of the yeast Hir Complex with Asf1/H3/H4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000417	cellular_component	HIR complex
A	0000775	cellular_component	chromosome, centromeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0016480	biological_process	negative regulation of transcription by RNA polymerase III
A	0031491	molecular_function	nucleosome binding
A	0034728	biological_process	nucleosome organization
A	0042802	molecular_function	identical protein binding
A	1902275	biological_process	regulation of chromatin organization
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000417	cellular_component	HIR complex
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003714	molecular_function	transcription corepressor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005829	cellular_component	cytosol
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0006338	biological_process	chromatin remodeling
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0016480	biological_process	negative regulation of transcription by RNA polymerase III
B	0031491	molecular_function	nucleosome binding
B	0140673	biological_process	transcription elongation-coupled chromatin remodeling
B	1902275	biological_process	regulation of chromatin organization
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000417	cellular_component	HIR complex
C	0000785	cellular_component	chromatin
C	0003677	molecular_function	DNA binding
C	0003714	molecular_function	transcription corepressor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0006338	biological_process	chromatin remodeling
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0016480	biological_process	negative regulation of transcription by RNA polymerase III
C	0031491	molecular_function	nucleosome binding
C	0140673	biological_process	transcription elongation-coupled chromatin remodeling
C	1902275	biological_process	regulation of chromatin organization
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000417	cellular_component	HIR complex
D	0003677	molecular_function	DNA binding
D	0003714	molecular_function	transcription corepressor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0006351	biological_process	DNA-templated transcription
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0031491	molecular_function	nucleosome binding
D	1902275	biological_process	regulation of chromatin organization
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0000417	cellular_component	HIR complex
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0006351	biological_process	DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0031491	molecular_function	nucleosome binding
E	1902275	biological_process	regulation of chromatin organization
F	0000082	biological_process	G1/S transition of mitotic cell cycle
F	0000417	cellular_component	HIR complex
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0006351	biological_process	DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0031491	molecular_function	nucleosome binding
F	1902275	biological_process	regulation of chromatin organization
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000417	cellular_component	HIR complex
G	0000775	cellular_component	chromosome, centromeric region
G	0000785	cellular_component	chromatin
G	0003677	molecular_function	DNA binding
G	0003714	molecular_function	transcription corepressor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006325	biological_process	chromatin organization
G	0006334	biological_process	nucleosome assembly
G	0006338	biological_process	chromatin remodeling
G	0006351	biological_process	DNA-templated transcription
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0016480	biological_process	negative regulation of transcription by RNA polymerase III
G	0031491	molecular_function	nucleosome binding
G	0034728	biological_process	nucleosome organization
G	0042802	molecular_function	identical protein binding
G	1902275	biological_process	regulation of chromatin organization
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000417	cellular_component	HIR complex
H	0000785	cellular_component	chromatin
H	0003677	molecular_function	DNA binding
H	0003714	molecular_function	transcription corepressor activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0005829	cellular_component	cytosol
H	0006325	biological_process	chromatin organization
H	0006334	biological_process	nucleosome assembly
H	0006338	biological_process	chromatin remodeling
H	0006351	biological_process	DNA-templated transcription
H	0006355	biological_process	regulation of DNA-templated transcription
H	0016480	biological_process	negative regulation of transcription by RNA polymerase III
H	0031491	molecular_function	nucleosome binding
H	0140673	biological_process	transcription elongation-coupled chromatin remodeling
H	1902275	biological_process	regulation of chromatin organization
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000417	cellular_component	HIR complex
I	0000785	cellular_component	chromatin
I	0003677	molecular_function	DNA binding
I	0003714	molecular_function	transcription corepressor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005694	cellular_component	chromosome
I	0005829	cellular_component	cytosol
I	0006325	biological_process	chromatin organization
I	0006334	biological_process	nucleosome assembly
I	0006338	biological_process	chromatin remodeling
I	0006351	biological_process	DNA-templated transcription
I	0006355	biological_process	regulation of DNA-templated transcription
I	0016480	biological_process	negative regulation of transcription by RNA polymerase III
I	0031491	molecular_function	nucleosome binding
I	0140673	biological_process	transcription elongation-coupled chromatin remodeling
I	1902275	biological_process	regulation of chromatin organization
J	0000082	biological_process	G1/S transition of mitotic cell cycle
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000417	cellular_component	HIR complex
J	0003677	molecular_function	DNA binding
J	0003714	molecular_function	transcription corepressor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005694	cellular_component	chromosome
J	0006325	biological_process	chromatin organization
J	0006334	biological_process	nucleosome assembly
J	0006351	biological_process	DNA-templated transcription
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0031491	molecular_function	nucleosome binding
J	1902275	biological_process	regulation of chromatin organization
K	0000082	biological_process	G1/S transition of mitotic cell cycle
K	0000417	cellular_component	HIR complex
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005694	cellular_component	chromosome
K	0006325	biological_process	chromatin organization
K	0006334	biological_process	nucleosome assembly
K	0006351	biological_process	DNA-templated transcription
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0031491	molecular_function	nucleosome binding
K	1902275	biological_process	regulation of chromatin organization
L	0000082	biological_process	G1/S transition of mitotic cell cycle
L	0000417	cellular_component	HIR complex
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005694	cellular_component	chromosome
L	0006325	biological_process	chromatin organization
L	0006334	biological_process	nucleosome assembly
L	0006351	biological_process	DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0031491	molecular_function	nucleosome binding
L	1902275	biological_process	regulation of chromatin organization
M	0000776	cellular_component	kinetochore
M	0000786	cellular_component	nucleosome
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005694	cellular_component	chromosome
M	0006325	biological_process	chromatin organization
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006878	biological_process	intracellular copper ion homeostasis
M	0007080	biological_process	mitotic metaphase chromosome alignment
M	0008823	molecular_function	cupric reductase (NADH) activity
M	0009060	biological_process	aerobic respiration
M	0009303	biological_process	rRNA transcription
M	0030527	molecular_function	structural constituent of chromatin
M	0031492	molecular_function	nucleosomal DNA binding
M	0031507	biological_process	heterochromatin formation
M	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
M	0042802	molecular_function	identical protein binding
M	0043505	cellular_component	CENP-A containing nucleosome
M	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
M	0045943	biological_process	positive regulation of transcription by RNA polymerase I
M	0046982	molecular_function	protein heterodimerization activity
M	0051382	biological_process	kinetochore assembly
M	0070911	biological_process	global genome nucleotide-excision repair
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0006325	biological_process	chromatin organization
N	0006334	biological_process	nucleosome assembly
N	0006355	biological_process	regulation of DNA-templated transcription
N	0030527	molecular_function	structural constituent of chromatin
N	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
N	0042802	molecular_function	identical protein binding
N	0045943	biological_process	positive regulation of transcription by RNA polymerase I
N	0046982	molecular_function	protein heterodimerization activity
O	0000781	cellular_component	chromosome, telomeric region
O	0000785	cellular_component	chromatin
O	0001932	biological_process	regulation of protein phosphorylation
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005829	cellular_component	cytosol
O	0006282	biological_process	regulation of DNA repair
O	0006325	biological_process	chromatin organization
O	0006334	biological_process	nucleosome assembly
O	0006335	biological_process	DNA replication-dependent chromatin assembly
O	0006337	biological_process	nucleosome disassembly
O	0006338	biological_process	chromatin remodeling
O	0006351	biological_process	DNA-templated transcription
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0010468	biological_process	regulation of gene expression
O	0010698	molecular_function	acetyltransferase activator activity
O	0030466	biological_process	silent mating-type cassette heterochromatin formation
O	0031509	biological_process	subtelomeric heterochromatin formation
O	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
O	0033554	biological_process	cellular response to stress
O	0042393	molecular_function	histone binding
O	0070775	cellular_component	H3 histone acetyltransferase complex
O	2000002	biological_process	negative regulation of DNA damage checkpoint

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
N	GLY15-HIS19

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. FIFNSPFLLkI

Chain	Residue	Details
D	PHE743-ILE753

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
M	LYS15-LEU21

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. ATSGstDgTILVWNT

Chain	Residue	Details
B	ALA294-THR308
A	LEU152-GLY166

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
M	PRO67-ILE75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	152
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	158
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	154
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	158
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	162
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	242
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	78
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	148
Details	Repeat: {"description":"WD 8"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"16768447","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N6-glutaryllysine","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	142
Details	Region: {"description":"Interaction with HIR1"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)