Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8GHM

Hir1 WD40 domains and Asf1/H3/H4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000417	cellular_component	HIR complex
A	0000775	cellular_component	chromosome, centromeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0016480	biological_process	negative regulation of transcription by RNA polymerase III
A	0031491	molecular_function	nucleosome binding
A	0034728	biological_process	nucleosome organization
A	0042802	molecular_function	identical protein binding
A	1905268	biological_process	negative regulation of chromatin organization
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000417	cellular_component	HIR complex
D	0003677	molecular_function	DNA binding
D	0003714	molecular_function	transcription corepressor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0031491	molecular_function	nucleosome binding
D	1905268	biological_process	negative regulation of chromatin organization
F	0000082	biological_process	G1/S transition of mitotic cell cycle
F	0000417	cellular_component	HIR complex
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0031491	molecular_function	nucleosome binding
F	1905268	biological_process	negative regulation of chromatin organization
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000417	cellular_component	HIR complex
G	0000775	cellular_component	chromosome, centromeric region
G	0000785	cellular_component	chromatin
G	0003677	molecular_function	DNA binding
G	0003714	molecular_function	transcription corepressor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006325	biological_process	chromatin organization
G	0006334	biological_process	nucleosome assembly
G	0006338	biological_process	chromatin remodeling
G	0006351	biological_process	DNA-templated transcription
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0016480	biological_process	negative regulation of transcription by RNA polymerase III
G	0031491	molecular_function	nucleosome binding
G	0034728	biological_process	nucleosome organization
G	0042802	molecular_function	identical protein binding
G	1905268	biological_process	negative regulation of chromatin organization
J	0000082	biological_process	G1/S transition of mitotic cell cycle
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000417	cellular_component	HIR complex
J	0003677	molecular_function	DNA binding
J	0003714	molecular_function	transcription corepressor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005694	cellular_component	chromosome
J	0006325	biological_process	chromatin organization
J	0006334	biological_process	nucleosome assembly
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0031491	molecular_function	nucleosome binding
J	1905268	biological_process	negative regulation of chromatin organization
L	0000082	biological_process	G1/S transition of mitotic cell cycle
L	0000417	cellular_component	HIR complex
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005694	cellular_component	chromosome
L	0006325	biological_process	chromatin organization
L	0006334	biological_process	nucleosome assembly
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0031491	molecular_function	nucleosome binding
L	1905268	biological_process	negative regulation of chromatin organization
M	0000500	cellular_component	RNA polymerase I upstream activating factor complex
M	0000786	cellular_component	nucleosome
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005694	cellular_component	chromosome
M	0006325	biological_process	chromatin organization
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006878	biological_process	intracellular copper ion homeostasis
M	0008823	molecular_function	cupric reductase (NADH) activity
M	0009060	biological_process	aerobic respiration
M	0009303	biological_process	rRNA transcription
M	0030527	molecular_function	structural constituent of chromatin
M	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
M	0043505	cellular_component	CENP-A containing nucleosome
M	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
M	0045943	biological_process	positive regulation of transcription by RNA polymerase I
M	0046982	molecular_function	protein heterodimerization activity
M	0070911	biological_process	global genome nucleotide-excision repair
N	0000500	cellular_component	RNA polymerase I upstream activating factor complex
N	0000786	cellular_component	nucleosome
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0006325	biological_process	chromatin organization
N	0006334	biological_process	nucleosome assembly
N	0006355	biological_process	regulation of DNA-templated transcription
N	0030527	molecular_function	structural constituent of chromatin
N	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
N	0042802	molecular_function	identical protein binding
N	0045943	biological_process	positive regulation of transcription by RNA polymerase I
N	0046982	molecular_function	protein heterodimerization activity
O	0000781	cellular_component	chromosome, telomeric region
O	0000785	cellular_component	chromatin
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005829	cellular_component	cytosol
O	0006282	biological_process	regulation of DNA repair
O	0006325	biological_process	chromatin organization
O	0006334	biological_process	nucleosome assembly
O	0006335	biological_process	DNA replication-dependent chromatin assembly
O	0006337	biological_process	nucleosome disassembly
O	0006338	biological_process	chromatin remodeling
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0010468	biological_process	regulation of gene expression
O	0010698	molecular_function	acetyltransferase activator activity
O	0030466	biological_process	silent mating-type cassette heterochromatin formation
O	0031509	biological_process	subtelomeric heterochromatin formation
O	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
O	0033554	biological_process	cellular response to stress
O	0042393	molecular_function	histone binding
O	0070775	cellular_component	H3 histone acetyltransferase complex
O	2000002	biological_process	negative regulation of DNA damage checkpoint

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
N	GLY15-HIS19

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. FIFNSPFLLkI

Chain	Residue	Details
J	PHE743-ILE753

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
M	LYS15-LEU21

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVTVglDrSVIVWNG

Chain	Residue	Details
A	LEU152-GLY166

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
M	PRO67-ILE75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	DNA_BIND:

Chain	Residue	Details
N	LYS17-LYS21
L	SER47

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269\|PubMed:22343720

Chain	Residue	Details
N	LYS6
N	LYS9
N	LYS13
L	SER435

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:11080160, ECO:0000269\|PubMed:15150415, ECO:0000269\|PubMed:17289592, ECO:0000269\|PubMed:19113941

Chain	Residue	Details
N	LYS17

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
N	LYS32
N	LYS78

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269\|PubMed:19113941

Chain	Residue	Details
N	ARG56
M	LYS57

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
N	SER61

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17287358, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
N	SER65

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:16768447

Chain	Residue	Details
N	LYS80

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-glutaryllysine => ECO:0000269\|PubMed:31542297

Chain	Residue	Details
N	LYS92

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)