8GHL

the Hir complex core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000417	cellular_component	HIR complex
A	0000775	cellular_component	chromosome, centromeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0016480	biological_process	negative regulation of transcription by RNA polymerase III
A	0031491	molecular_function	nucleosome binding
A	0034728	biological_process	nucleosome organization
A	0042802	molecular_function	identical protein binding
A	1902275	biological_process	regulation of chromatin organization
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000417	cellular_component	HIR complex
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003714	molecular_function	transcription corepressor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005829	cellular_component	cytosol
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0006338	biological_process	chromatin remodeling
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0016480	biological_process	negative regulation of transcription by RNA polymerase III
B	0031491	molecular_function	nucleosome binding
B	0140673	biological_process	transcription elongation-coupled chromatin remodeling
B	1902275	biological_process	regulation of chromatin organization
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000417	cellular_component	HIR complex
C	0000785	cellular_component	chromatin
C	0003677	molecular_function	DNA binding
C	0003714	molecular_function	transcription corepressor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0006338	biological_process	chromatin remodeling
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0016480	biological_process	negative regulation of transcription by RNA polymerase III
C	0031491	molecular_function	nucleosome binding
C	0140673	biological_process	transcription elongation-coupled chromatin remodeling
C	1902275	biological_process	regulation of chromatin organization
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000417	cellular_component	HIR complex
D	0003677	molecular_function	DNA binding
D	0003714	molecular_function	transcription corepressor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0006351	biological_process	DNA-templated transcription
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0031491	molecular_function	nucleosome binding
D	1902275	biological_process	regulation of chromatin organization
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000417	cellular_component	HIR complex
G	0000775	cellular_component	chromosome, centromeric region
G	0000785	cellular_component	chromatin
G	0003677	molecular_function	DNA binding
G	0003714	molecular_function	transcription corepressor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006325	biological_process	chromatin organization
G	0006334	biological_process	nucleosome assembly
G	0006338	biological_process	chromatin remodeling
G	0006351	biological_process	DNA-templated transcription
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0016480	biological_process	negative regulation of transcription by RNA polymerase III
G	0031491	molecular_function	nucleosome binding
G	0034728	biological_process	nucleosome organization
G	0042802	molecular_function	identical protein binding
G	1902275	biological_process	regulation of chromatin organization
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000417	cellular_component	HIR complex
H	0000785	cellular_component	chromatin
H	0003677	molecular_function	DNA binding
H	0003714	molecular_function	transcription corepressor activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0005829	cellular_component	cytosol
H	0006325	biological_process	chromatin organization
H	0006334	biological_process	nucleosome assembly
H	0006338	biological_process	chromatin remodeling
H	0006351	biological_process	DNA-templated transcription
H	0006355	biological_process	regulation of DNA-templated transcription
H	0016480	biological_process	negative regulation of transcription by RNA polymerase III
H	0031491	molecular_function	nucleosome binding
H	0140673	biological_process	transcription elongation-coupled chromatin remodeling
H	1902275	biological_process	regulation of chromatin organization
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000417	cellular_component	HIR complex
I	0000785	cellular_component	chromatin
I	0003677	molecular_function	DNA binding
I	0003714	molecular_function	transcription corepressor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005694	cellular_component	chromosome
I	0005829	cellular_component	cytosol
I	0006325	biological_process	chromatin organization
I	0006334	biological_process	nucleosome assembly
I	0006338	biological_process	chromatin remodeling
I	0006351	biological_process	DNA-templated transcription
I	0006355	biological_process	regulation of DNA-templated transcription
I	0016480	biological_process	negative regulation of transcription by RNA polymerase III
I	0031491	molecular_function	nucleosome binding
I	0140673	biological_process	transcription elongation-coupled chromatin remodeling
I	1902275	biological_process	regulation of chromatin organization
J	0000082	biological_process	G1/S transition of mitotic cell cycle
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000417	cellular_component	HIR complex
J	0003677	molecular_function	DNA binding
J	0003714	molecular_function	transcription corepressor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005694	cellular_component	chromosome
J	0006325	biological_process	chromatin organization
J	0006334	biological_process	nucleosome assembly
J	0006351	biological_process	DNA-templated transcription
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0031491	molecular_function	nucleosome binding
J	1902275	biological_process	regulation of chromatin organization

Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. FIFNSPFLLkI

Chain	Residue	Details
J	PHE743-ILE753

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVTVglDrSVIVWNG

Chain	Residue	Details
A	LEU152-GLY166
B	ALA294-THR308

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	164
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	148
Details	Repeat: {"description":"WD 8"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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