Functional Information from PROSITE/UniProt
site_id | PS00194 |
Number of Residues | 19 |
Details | THIOREDOXIN_1 Thioredoxin family active site. LVeFYapWCGHCRaLapeY |
Chain | Residue | Details |
A | LEU45-TYR63 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile |
Chain | Residue | Details |
A | CYS53 | |
A | CYS56 | |
B | CYS53 | |
B | CYS56 | |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Contributes to redox potential value |
Chain | Residue | Details |
A | GLY54 | |
A | HIS55 | |
B | GLY54 | |
B | HIS55 | |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Lowers pKa of C-terminal Cys of first active site |
Chain | Residue | Details |
A | ARG120 | |
B | ARG120 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 191 |
Chain | Residue | Details |
A | CYS53 | nucleofuge, nucleophile, proton acceptor, proton donor |
A | GLY54 | activator, modifies pKa |
A | HIS55 | modifies pKa, proton acceptor, proton donor |
A | CYS56 | |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 191 |
Chain | Residue | Details |
B | CYS53 | nucleofuge, nucleophile, proton acceptor, proton donor |
B | GLY54 | activator, modifies pKa |
B | HIS55 | modifies pKa, proton acceptor, proton donor |
B | CYS56 | |