8GB3

Structure of the Mycobacterium tuberculosis Hsp70 protein DnaK bound to the nucleotide exchange factor GrpE

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0001968	molecular_function	fibronectin binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006457	biological_process	protein folding
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0009408	biological_process	response to heat
D	0009986	cellular_component	cell surface
D	0010756	biological_process	positive regulation of plasminogen activation
D	0016887	molecular_function	ATP hydrolysis activity
D	0031072	molecular_function	heat shock protein binding
D	0035375	molecular_function	zymogen binding
D	0042026	biological_process	protein refolding
D	0042603	cellular_component	capsule
D	0044183	molecular_function	protein folding chaperone
D	0044406	biological_process	adhesion of symbiont to host
D	0046677	biological_process	response to antibiotic
D	0046688	biological_process	response to copper ion
D	0046777	biological_process	protein autophosphorylation
D	0051082	molecular_function	unfolded protein binding
D	0051085	biological_process	chaperone cofactor-dependent protein refolding
D	0071451	biological_process	cellular response to superoxide
D	0097691	cellular_component	bacterial extracellular vesicle
D	0140662	molecular_function	ATP-dependent protein folding chaperone
D	2000679	biological_process	positive regulation of transcription regulatory region DNA binding
E	0000774	molecular_function	adenyl-nucleotide exchange factor activity
E	0005737	cellular_component	cytoplasm
E	0006457	biological_process	protein folding
E	0009267	biological_process	cellular response to starvation
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0042803	molecular_function	protein homodimerization activity
E	0051082	molecular_function	unfolded protein binding
E	0051087	molecular_function	protein-folding chaperone binding
F	0000774	molecular_function	adenyl-nucleotide exchange factor activity
F	0005737	cellular_component	cytoplasm
F	0006457	biological_process	protein folding
F	0009267	biological_process	cellular response to starvation
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0042803	molecular_function	protein homodimerization activity
F	0051082	molecular_function	unfolded protein binding
F	0051087	molecular_function	protein-folding chaperone binding

Functional Information from PROSITE/UniProt

site_id	PS00297
Number of Residues	8
Details	HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTnS

Chain	Residue	Details
D	ILE7-SER14

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site_id	PS00329
Number of Residues	14
Details	HSP70_2 Heat shock hsp70 proteins family signature 2. VFDLGGGTfdvSLL

Chain	Residue	Details
D	VAL168-LEU181

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site_id	PS01036
Number of Residues	15
Details	HSP70_3 Heat shock hsp70 proteins family signature 3. VvLvGGsTRMPaVtD

Chain	Residue	Details
D	VAL310-ASP324

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site_id	PS01071
Number of Residues	45
Details	GRPE grpE protein signature. FDPvlHeAVqhegdggqgskpvigtvmrq.GYqlg.Eqv.LRhAlVgV

Chain	Residue	Details
E	PHE142-VAL186

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609

Chain	Residue	Details
E	THR2
F	THR2

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