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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8G7V

Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-inter)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002230biological_processpositive regulation of defense response to virus by host
A0002376biological_processimmune system process
A0002684biological_processpositive regulation of immune system process
A0002735biological_processpositive regulation of myeloid dendritic cell cytokine production
A0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
A0003676molecular_functionnucleic acid binding
A0003690molecular_functiondouble-stranded DNA binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003725molecular_functiondouble-stranded RNA binding
A0003727molecular_functionsingle-stranded RNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005923cellular_componentbicellular tight junction
A0008270molecular_functionzinc ion binding
A0009597biological_processdetection of virus
A0009615biological_processresponse to virus
A0010467biological_processgene expression
A0010628biological_processpositive regulation of gene expression
A0015629cellular_componentactin cytoskeleton
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0030334biological_processregulation of cell migration
A0031625molecular_functionubiquitin protein ligase binding
A0032587cellular_componentruffle membrane
A0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
A0032727biological_processpositive regulation of interferon-alpha production
A0032728biological_processpositive regulation of interferon-beta production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0034344biological_processregulation of type III interferon production
A0038187molecular_functionpattern recognition receptor activity
A0039529biological_processRIG-I signaling pathway
A0042802molecular_functionidentical protein binding
A0043330biological_processresponse to exogenous dsRNA
A0045087biological_processinnate immune response
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0051607biological_processdefense response to virus
A0060760biological_processpositive regulation of response to cytokine stimulus
A0071360biological_processcellular response to exogenous dsRNA
A0140374biological_processantiviral innate immune response
A1990904cellular_componentribonucleoprotein complex
B0000209biological_processprotein polyubiquitination
B0002376biological_processimmune system process
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0008270molecular_functionzinc ion binding
B0010494cellular_componentcytoplasmic stress granule
B0010994biological_processfree ubiquitin chain polymerization
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0032728biological_processpositive regulation of interferon-beta production
B0039529biological_processRIG-I signaling pathway
B0039552molecular_functionRIG-I binding
B0042802molecular_functionidentical protein binding
B0043021molecular_functionribonucleoprotein complex binding
B0045087biological_processinnate immune response
B0045088biological_processregulation of innate immune response
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0061630molecular_functionubiquitin protein ligase activity
B0070534biological_processprotein K63-linked ubiquitination
B0140374biological_processantiviral innate immune response
B1990904cellular_componentribonucleoprotein complex
C0000166molecular_functionnucleotide binding
C0002230biological_processpositive regulation of defense response to virus by host
C0002376biological_processimmune system process
C0002684biological_processpositive regulation of immune system process
C0002735biological_processpositive regulation of myeloid dendritic cell cytokine production
C0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
C0003676molecular_functionnucleic acid binding
C0003690molecular_functiondouble-stranded DNA binding
C0003723molecular_functionRNA binding
C0003724molecular_functionRNA helicase activity
C0003725molecular_functiondouble-stranded RNA binding
C0003727molecular_functionsingle-stranded RNA binding
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005923cellular_componentbicellular tight junction
C0008270molecular_functionzinc ion binding
C0009597biological_processdetection of virus
C0009615biological_processresponse to virus
C0010467biological_processgene expression
C0010628biological_processpositive regulation of gene expression
C0015629cellular_componentactin cytoskeleton
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0030334biological_processregulation of cell migration
C0031625molecular_functionubiquitin protein ligase binding
C0032587cellular_componentruffle membrane
C0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
C0032727biological_processpositive regulation of interferon-alpha production
C0032728biological_processpositive regulation of interferon-beta production
C0032755biological_processpositive regulation of interleukin-6 production
C0032757biological_processpositive regulation of interleukin-8 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0034344biological_processregulation of type III interferon production
C0038187molecular_functionpattern recognition receptor activity
C0039529biological_processRIG-I signaling pathway
C0042802molecular_functionidentical protein binding
C0043330biological_processresponse to exogenous dsRNA
C0045087biological_processinnate immune response
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046872molecular_functionmetal ion binding
C0051607biological_processdefense response to virus
C0060760biological_processpositive regulation of response to cytokine stimulus
C0071360biological_processcellular response to exogenous dsRNA
C0140374biological_processantiviral innate immune response
C1990904cellular_componentribonucleoprotein complex
D0000209biological_processprotein polyubiquitination
D0002376biological_processimmune system process
D0004842molecular_functionubiquitin-protein transferase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0008270molecular_functionzinc ion binding
D0010494cellular_componentcytoplasmic stress granule
D0010994biological_processfree ubiquitin chain polymerization
D0016567biological_processprotein ubiquitination
D0016740molecular_functiontransferase activity
D0032728biological_processpositive regulation of interferon-beta production
D0039529biological_processRIG-I signaling pathway
D0039552molecular_functionRIG-I binding
D0042802molecular_functionidentical protein binding
D0043021molecular_functionribonucleoprotein complex binding
D0045087biological_processinnate immune response
D0045088biological_processregulation of innate immune response
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0061630molecular_functionubiquitin protein ligase activity
D0070534biological_processprotein K63-linked ubiquitination
D0140374biological_processantiviral innate immune response
D1990904cellular_componentribonucleoprotein complex
Functional Information from PROSITE/UniProt
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHsFCrhCL
ChainResidueDetails
BCYS36-LEU45
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues358
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues6
DetailsMotif: {"description":"DECH box"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01125","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"(Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37","evidences":[{"source":"PubMed","id":"27866900","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by CK2","evidences":[{"source":"PubMed","id":"21068236","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"21068236","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"26746851","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q6Q899","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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