8G72
SARS-CoV-2 spike/Nb2 complex with 1 RBD up (local refinement at 5.6 A)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0019031 | cellular_component | viral envelope |
| B | 0019062 | biological_process | virion attachment to host cell |
| B | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| B | 0020002 | cellular_component | host cell plasma membrane |
| B | 0039587 | biological_process | symbiont-mediated-mediated suppression of host tetherin activity |
| B | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| B | 0039660 | molecular_function | structural constituent of virion |
| B | 0039663 | biological_process | membrane fusion involved in viral entry into host cell |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043655 | cellular_component | host extracellular space |
| B | 0044173 | cellular_component | host cell endoplasmic reticulum-Golgi intermediate compartment membrane |
| B | 0044228 | cellular_component | host cell surface |
| B | 0044423 | cellular_component | virion component |
| B | 0046598 | biological_process | positive regulation of viral entry into host cell |
| B | 0046718 | biological_process | symbiont entry into host cell |
| B | 0046789 | molecular_function | host cell surface receptor binding |
| B | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| B | 0048018 | molecular_function | receptor ligand activity |
| B | 0052031 | biological_process | symbiont-mediated perturbation of host defense response |
| B | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| B | 0055036 | cellular_component | virion membrane |
| B | 0061025 | biological_process | membrane fusion |
| B | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| B | 0098670 | biological_process | entry receptor-mediated virion attachment to host cell |
| B | 0141146 | biological_process | symbiont-mediated disruption of host tissue |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Region: {"description":"Integrin-binding motif;","evidences":[{"source":"PubMed","id":"33102950","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Immunodominant HLA epitope recognized by the CD8+; called NF9 peptide","evidences":[{"source":"PubMed","id":"34171266","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"35108439","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GalNAc) threonine; by host","evidences":[{"source":"PubMed","id":"32363391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (HexNAc...) serine; by host","evidences":[{"source":"PubMed","id":"32363391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32155444","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32363391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32366695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32979942","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
