8G54

Temperature-dependent structures of tau aggregates

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008017	molecular_function	microtubule binding
A	0015631	molecular_function	tubulin binding
B	0008017	molecular_function	microtubule binding
B	0015631	molecular_function	tubulin binding
C	0008017	molecular_function	microtubule binding
C	0015631	molecular_function	tubulin binding
D	0008017	molecular_function	microtubule binding
D	0015631	molecular_function	tubulin binding
E	0008017	molecular_function	microtubule binding
E	0015631	molecular_function	tubulin binding

Functional Information from PROSITE/UniProt

site_id	PS00229
Number of Residues	13
Details	TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG

Chain	Residue	Details
A	GLY261-GLY273
A	GLY292-GLY304
A	GLY323-GLY335
A	GLY355-GLY367

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	SITE: Not glycated => ECO:0000269|PubMed:9326300

Chain	Residue	Details
A	ASN381
C	GLU391
C	ILE392
C	TYR394
D	ASN381
D	GLU391
D	ILE392
D	TYR394
E	ASN381
E	GLU391
E	ILE392
A	GLU391
E	TYR394
A	ILE392
A	TYR394
B	ASN381
B	GLU391
B	ILE392
B	TYR394
C	ASN381

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site_id	SWS_FT_FI2
Number of Residues	5
Details	MOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:16982696

Chain	Residue	Details
A	SER214
B	SER214
C	SER214
D	SER214
E	SER214

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site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: Phosphoserine; in PHF-tau => ECO:0000269|PubMed:1899488

Chain	Residue	Details
A	SER396
B	SER396
C	SER396
D	SER396
E	SER396

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site_id	SWS_FT_FI4
Number of Residues	5
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300

Chain	Residue	Details
A	LYS383
B	LYS383
C	LYS383
D	LYS383
E	LYS383

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