8G4U

Final ketosynthase+acyltransferase of the erythromycin modular polyketide synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
C	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
C	0006633	biological_process	fatty acid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00599
Number of Residues	10
Details	AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TYGKSRGSSG

Chain	Residue	Details
A	THR1810-GLY1819

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site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPAvtVDtACSSSlvAL

Chain	Residue	Details
A	GLY1648-LEU1664

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Acyl-thioester intermediate; for beta-ketoacyl synthase 2 activity => ECO:0000255|PROSITE-ProRule:PRU01348

Chain	Residue	Details
A	CYS1657
B	CYS1657
C	CYS1657
D	CYS1657

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site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: For beta-ketoacyl synthase 2 activity => ECO:0000255|PROSITE-ProRule:PRU01348

Chain	Residue	Details
A	GLY1793
A	ALA1833
B	GLY1793
B	ALA1833
C	GLY1793
C	ALA1833
D	GLY1793
D	ALA1833

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site_id	SWS_FT_FI3
Number of Residues	4
Details	ACT_SITE: Acyl-ester intermediate; for acyltransferase 2 activity => ECO:0000255|PROSITE-ProRule:PRU10022

Chain	Residue	Details
A	GLN2108
B	GLN2108
C	GLN2108
D	GLN2108

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 602

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 602

Chain

Residue

Details

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site_id	MCSA3
Number of Residues
Details	M-CSA 602

Chain

Residue

Details

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site_id	MCSA4
Number of Residues
Details	M-CSA 602

Chain

Residue

Details

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