Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
Functional Information from PROSITE/UniProt
| site_id | PS00118 |
| Number of Residues | 8 |
| Details | PA2_HIS Phospholipase A2 histidine active site. CCFvHDcC |
| Chain | Residue | Details |
| B | CYS44-CYS51 | |
| A | CYS44-CYS51 | |
| site_id | PS00119 |
| Number of Residues | 11 |
| Details | PA2_ASP Phospholipase A2 aspartic acid active site. ICECDRVAaEC |
| Chain | Residue | Details |
| B | ILE95-CYS105 | |
| A | ILE95-CYS105 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Region: {"description":"Putative region that binds to the R48 receptor (PubMed:21787789)","evidences":[{"source":"PubMed","id":"21787789","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P62022","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P62022","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Site: {"description":"Putative interfacial binding surface (IBS)","evidences":[{"source":"PubMed","id":"21787789","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Binds Q-49 of CBa2","evidences":[{"source":"PubMed","id":"21787789","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Binds G-45 of CBa2","evidences":[{"source":"PubMed","id":"21787789","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Binds D-105 of CBa2, important for stability (T-31)","evidences":[{"source":"PubMed","id":"21787789","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"Binds E-93 of CBa2","evidences":[{"source":"PubMed","id":"21787789","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Site: {"description":"Binds D-95 of CBa2, important for stability (T-70)","evidences":[{"source":"PubMed","id":"21787789","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"Responsible for the weak stability and toxicity","evidences":[{"source":"UniProtKB","id":"P62022","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 9 |
| Details | Site: {"description":"Putative interfacial binding surface (IBS)","evidences":[{"source":"UniProtKB","id":"P62022","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Site: {"description":"Responsible for the higher anticoagulant activity (compared with CBa2)","evidences":[{"source":"UniProtKB","id":"P62022","evidenceCode":"ECO:0000250"}]} |
8G4B
